Gulu loyambitsa jekeseni limachepetsa kupweteka kwa mafupa osteoarthritis
Synvisc (hylan GF 20) ndi mchere wamadzi wochokera ku chinthu chotchedwa hyaluronan (sodium hyaluronate). Hyaluronan imapangidwa mwachibadwa m'thupi kuti imathandizire mafuta. Fomu yomwe imapezeka mu Synvisc imapangidwa kuchokera ku gelatinous zinthu zomwe zimachokera ku nkhuku za nkhuku.
Synvisc imagwiritsidwa ntchito mwa mtundu wina wa mankhwala omwe amadziwika kuti viscosupplementation momwe mankhwalawa amayidwira mu malo ophatikizira kuti athandizire kuchulukitsa mafuta.
Zambiri za mankhwala
Majekeseni a Synvisc amavomerezedwa kuti athe kuchiritsira matenda a osteoarthritis a bondo mwa anthu omwe alephera kuyankha mankhwala othandiza kwambiri, kuphatikizapo analgesics ndi osakhala mankhwala.
Synvisc imaperekedwa mu jekeseni lawiri-mililita molumikizana ndi bondo. Simunayambe kuvomerezedwa kuti aziphatikizidwapo pambali pa bondo. Synvisc imaperekedwa ngati katemera katatu sabata iliyonse. Kuti tipeze zotsatira zabwino, synovial madzi m'mphepete mwa bondo amachotsedwa pamaso pa jekeseni yoyamba.
Palinso chinthu china chotchedwa Synvisc, chotchedwa Synvisc-One, chomwe chimaperekedwa ngati imodzi, kuwombera mamiliyoni asanu ndi limodzi.
Synvisc inavomerezedwa kuti igwiritsidwe ntchito ndi US Food and Drug Administration pa August 8, 1997. Synvisc-One inalandira chivomerezo chake cha FDA pa February 26, 2009. Zotsatira zoyipa zogwirizana ndi Synvisc zikuphatikizapo:
- Ululu, kutupa, kapena kuuma muondo wololedwa
- Kusokoneza pamodzi ("madzi mu bondo")
- Kumva ululu wokhudzana
- Msuzi kapena ming'oma
- Fever
- Nausea
- Mutu
- Chizungulire
- Mitsempha ya minofu
- Kutopa
Zambiri mwazizindikirozi ndi zochepa komanso zochepa kwambiri ndipo zidzathetsa okha popanda mankhwala. Ngati zizindikiro zilizonse zikupitirira kapena kuwonjezereka, pitani kuchipatala mwamsanga chifukwa izi zingakhale chizindikiro cha matenda kapena zovuta.
Kugwira ntchito kwa Synvisc mu Kutaya Opaleshoni Yoyenda
Chiyeso cha kuchipatala chinachitidwa kuti aone momwe Synvisc ilili yabwino kwa anthu omwe ali ndi mafupa osteoarthritis a maondo awiri kapena awiri. Anthuwa ndi amayi 56 ndi amuna 52 omwe ali ndi zaka makumi asanu ndi awiri mphambu zisanu ndi ziwiri (62). Aliyense adalephera kupeza chithandizo ndi mankhwala osokoneza bongo (NSAIDs) kapena ma shoti a cortisone .
Pakati pa mulandu, wophunzira aliyense analandira jekeseni zitatu za Synvisc sabata imodzi pambali. Kuyesedwa kunkachitika pa imodzi, itatu, sikisi, 12, 15 ndi miyezi 18. Phunziroli linalimbikitsa kufufuza zomwe ophunzira omwe amaphunzira amamva kupwetekedwa mtima ndikuwunikira momwe chithandizochi chinalili pothandizira kuchepetsa kugwiritsidwa ntchito kwa mawondo (TKR) .
Pamapeto pake, ofufuza anapeza kuti odwala 72,6 peresenti anachitidwa opaleshoni ya TKR yosavomerezeka nthawi yonse yophunzira. Ngakhale kuti panalibe zotsatira zoyipa kapena zazing'ono, anthu asanu ndi atatu adamva zowawa kwambiri pakutsatira majekeseni. Palibe ankaonedwa kuti ndi ovuta.
Kuchokera ku Western Ontario ndi McMaster Universities Osteoarthritis Index ( WOMAC ), kafukufuku wogwiritsidwa ntchito poyeza kuchuluka kwa maulendo opweteka, anthu a Synvisc anapeza pafupifupi 20 peresenti akugwetsa ululu poyerekeza ndi omwe ali pa placebo.
Mtundu wa mafupa a m'magazi masiku ano ndiwo mtundu wambiri wa nyamakazi ku United States, womwe umakhudza anthu pafupifupi 13.7 miliyoni. Malinga ndi zomwe apeza, Synvisc imaonedwa kuti ndi njira yabwino komanso yothetsera vutoli ndi olemala m'dera lino ndipo zikagwiritsidwa ntchito moyenera, zingathandize kuchepetsa opaleshoni kwa zaka zitatu kapena kuposerapo.
> Chitsime:
> Utsogoleri wa US Food and Drug Administration. (2008) "Chidule cha Synvisc-Chimodzi cha Chidziwitso ndi Chitetezo." Silver Spring, Maryland.