A Corticosteroid Yapangidwira Kutulutsidwa Kwambiri
Rayos ( prednisone ), omwe amadziwika kuti Lodotra ku Ulaya, ndi kutulutsidwa kochedwa-release release dose prednisone. Rayos, yopangidwa ndi Horizon Pharma, inavomerezedwa ndi US Food and Drug Administration (FDA) pa July 26, 2012, chifukwa cha nyamakazi ya nyamakazi ndi zizindikiro zina zingapo.
Chivomerezo cha FDA chinachokera ku deta yomwe inkayerekeza pharmacokinetics (mwachitsanzo, momwe mankhwalawa amathandizidwira, kupangidwira, kuchotsedwa) kwa Rayos ku prednisone yomwe imatulutsidwa mwamsanga, komanso data kuchokera ku Circadian Administration ya Prednisone mu RA (CAPRA-1 ndi 2 ) mayesero.
CAPRA-2 inasonyeza kuti anthu omwe ali ndi nyamakazi yovuta kwambiri yodwala nyamakazi omwe anachiritsidwa ndi Rayos anapeza kusintha kwakukulu kwa mayankho a ACR20 poyerekeza ndi placebo, komanso kusintha kwakukulu pamtunda wa kutopa. CAPRA-1 inawonetsa chitetezo chonse cha Rayos.
Zisonyezo
Rayos ndi corticosteroid yotsutsana ndi zotupa kapena zotupa za thupi zomwe zimagwiritsidwa ntchito pofuna kuthana ndi matenda enaake, dermatologic, endocrine, m'mimba, hematologic, neoplastic, nervous system, ophthalmologic, renal, kupuma, ndi ma rheumatological.
Ponena za mikhalidwe ya rheumatologic, Rayos angagwiritsidwe ntchito panthawi yamphindi yochepa ya mthenda yamatenda. Rayos angagwiritsidwenso ntchito m'maganizo ena a ankylosing spondylitis , dermatomyositis, polymyositis, polymyalgia rheumatica , psoriatic nyamakazi , kubwereranso polychondritis, nyamakazi ya nyamakazi, Sjogren's syndrome , systemic lupus erythematosus , ndi vasculitis .
Kupezeka
Rayos amapezeka ngati 1 mg, 2 mg, ndi 5 mg. pulogalamu yamatulutsidwa yochedwa.
Kusankha
Kusankha kuyenera kukhala payekhapayekha ndi kulingalira komwe kunaperekedwa ku matenda aakulu komanso ngati odwala akugwiritsa ntchito prednisone mwamsanga. Mlingo woyamba uli pafupifupi 5 mg. wa Rayos kamodzi patsiku. Komabe, odwala omwe ali pa prednisone angafunike kusintha kwa mlingo kuti asinthe kwa Rayos.
Rayos ayenera kutengedwa ndi chakudya, ndipo piritsiyo iyenera kutengedwa. Pofuna kusamalira, mlingo wotsika kwambiri uyenera kugwiritsidwa ntchito. Kuchotsa ntchito kumayenera kukhala pang'onopang'ono.
Zotsatira Zovuta
Zotsatira zovuta kwambiri zomwe zimagwirizanitsidwa ndi ntchito ya corticosteroid zimaphatikizapo kusungunuka kwa madzi, kukwera kwa kuthamanga kwa magazi, kusinthika kwa shuga, kusinthasintha kwa thupi, kulemera kwa thupi, ndi kuwonjezeka kwa njala.
Palinso zovuta zina zomwe zimakhudzana ndi mawonekedwe ambiri a thupi. Chidziwitso chonse cha Rayos chili ndi mndandanda wambiri. Zovuta za musculoskeletal zomwe zimagwirizanitsidwa ndi corticosteroids ndi osteonecrosis ya mitu yachikazi ndi yaukali, kufooka kwa mitsempha, kufooka kwa minofu, kutayika kwa minofu, kupweteka kwa minofu, ndi kupweteka kwa thambo.
Contraindications
Rayos sayenera kugwiritsidwa ntchito ndi odwala omwe amatchedwa hypersensitivity kwa prednisone kapena zinthu zopanda mphamvu zomwe zili mu piritsi.
Machenjezo
- Odwala, makamaka omwe amadwala ndi prednisone kwa nthawi yaitali, ayenera kuyang'aniridwa ndi hypothalamic-pituitary-adrenal axis suppression, matenda a Cushing, ndi hyperglycemia.
- Pali chiwopsezo chowonjezereka ku matenda atsopano ndipo chinawonjezetsa chiopsezo cha kuwonjezereka kapena kubwezeretsanso kachilombo koyipa kwa odwala omwe akudwala Rayos kapena prednisone.
- Kupanikizika kwa magazi, komanso ma sodium ndi potassium ayenera kuyang'anitsitsa.Magwiritsidwe ntchito kameneka angakhudze mchere ndi kusungirako madzi.
- Pali chiopsezo chowonjezereka cha mitsempha ya m'mimba, kuphatikizapo perforation. Zizindikiro zikhoza kusungidwa.
- Euphoria, kusoŵa tulo, kusinthasintha maganizo, kusintha kwa umunthu, ndi kuvutika maganizo kwakukulu kumachitika. Kusokonezeka maganizo kumakhala koipitsitsa ndi ntchito ya prednisone.
- Kuchepetsa kupyapyala kwa mafupa kungathe kuchitika.
- Pakhoza kukhala ophthalmic zotsatira monga cataracts, glaucoma, ndi matenda.
- Kukhala ndi katemera kapena mavitamini ochepetsetsa osayenera kuperekedwa kwa odwala omwe ali ndi vuto la immnisone.
- Zoopsa za fetal zingachitike panthawi yoyamba ya mimba.
Kuyanjana kwa Mankhwala
Rayos angagwirizane ndi:
- Anticoagulants
- Mankhwala ochepetsa matenda a shuga
- CYP3A4 inducers ndi inhibitors
- Cyclosporine
- NSAIDs (mankhwala osakanizika ndi mankhwala osagwiritsidwa ntchito)
Onetsetsani kuti dokotala wanu amadziwa mankhwala onse ndi zowonjezereka zomwe mukuzitenga panopa. Ndikofunika kufufuza zoopsa zomwe zingakhalepo potsata chithandizo cha Rayos.
Kodi Kusiyana Ndi Chiyani?
Kodi Rayos amasiyana bwanji ndi prednisone? Mu mayesero a zachipatala, Rayos anaperekedwa pa 10 koloko ndi chakudya. Mbali ya Rayos yotulutsidwa yolepheretsa kuti mankhwala a prednisone m'magazi akwaniritsidwe pamene magulu a cytokine anayamba kuwonjezeka pakati pa usiku. Njirayi ingathandize kuchepetsa kutupa kwa odwala ena.
Zotsatira
Rayos. Kufotokozera Information.
http://www.rayosrx.com/PI/RAYOS-Poscribing-Information.pdf
Horizon Pharma Adalengeza FDA Kuvomerezeka kwa RAYOS® (prednisone) Ma tabletsedwe Operewera a Matenda a Nyamakazi ndi Zowonjezera Zowonjezera Zowonjezera. Horizon Pharma. July 2012.
http://ir.horizon-pharma.com/releasedetail.cfm?ReleaseID=695983