Mabotolo Osasokonezedwa ndi Celebrex

Mipata ya pulasitiki siidasokonezedwe ngakhale pafupipafupi kasanu ndi kamodzi kamene kamayambitsa matenda a osteoarthritis

Nkhaniyi ndi gawo la Archives Arthritis.

Dateline: February 20, 2000

Mabotolo Osasokonezedwa ndi Celebrex

Zotsatira za kafukufuku wopangidwa ndi kawiri-khungu, mwachangu, komanso pa malobo omwe anafalitsidwa m'magazini ya Journal of Clinical Pharmacology ya February 2000, adavumbula kuti mankhwala omwe amadziwika ndi matenda a nyamakazi a Celebrex (celecoxib) sagwirizanitsa ndi mapuloteni ngakhale 1200 mg / tsiku.

Mlingo wa 1200 mg / tsiku kwenikweni ndi 6 kuchuluka kwa mlingo wa Celebrex womwe umaperekedwa kuti uchitire mankhwala osteoarthritis.

Chifukwa chiyani kupeza izi kwasungunuka mapuloteni oyenera kumathandiza kwambiri? Ndizofunika kwa:

• Odwala ali pachiopsezo chokhala ndi magazi.
• Odwala amatenga mankhwala omwe amachulukitsa chiopsezo cha magazi.
• Anthu omwe ali ndi nyamakazi amene amatenga aspirin yaing'ono ya cardiovascular disease prophylaxis.

Za Phunziro

Cholinga cha phunziroli chinali kuyerekeza zotsatira za kuchuluka kwa mankhwala a Celebrex kwa mankhwala ochizira a naproxen pa mapaleletti.

• Celebrex ndi COX-2 inhibitor yosankha.
• Naproxen ndi NSAID yosasankha (mankhwala osakanikirana ndi anti-inflammatory).

Pa nthawi ya masiku khumi, ophunzira omwe amaphunzira amaperekedwa mobwerezabwereza magawo osiyanasiyana a:

• Celebrex
• naproxen
• malo a placebo

Nthawi zoyamba kubwezera zinkagwiritsidwa ntchito poyeza mapulogalamu. Mosiyana ndi Celebrex kapena placebo, naproxen inatsimikizira kuchepetsako magulu a mapepala ndi kuwonjezera nthawi zamagazi.

Mfundo yakuti Celebrex siidasokoneze magulu oyenera a platelet ndi chitsimikizo cha kusankha COX-2 kwa mankhwala ndi chitetezo chake.

Matenda a Osteoarthritis ndi Matenda a Mtima

Kaŵirikaŵiri osteoarthritis ndi matenda a mtima zimachitika pakati pa anthu okalamba. CDC (Centers for Disease Control and Prevention) yanena kuti munthu mmodzi pa anthu 4 alionse ku United States ali ndi matenda oopsa kwambiri ndipo anthu mmodzi mwa anthu atatu alionse omwe ali ndi matenda a hypertension ali ndi nyamakazi.

Pafupifupi 1 pa anthu asanu (5) opitirira zaka 35 amatenga aspirin ngati njira yothandizira kudwala matenda a mtima. Zotsatira zophunzira zimathandizira Celebrex ngati kusankha kwabwino kwa anthu pa aspirin yochepa ya regimen.

Zothandizira zokhudzana

• Celebrex (celecoxib)
• Osteoarthritis
• COX-2 Selective Inhibitors
• Zambiri Zokhudza NSAIDs

  _{Gwero: Journal of Clinical Pharmacology, February 16, 2000, MedscapeWire
  Choyamba chofalitsidwa: 02/20/2000}