Komabe Sikuti FDA inavomerezedwa
Ampligen (rintatolimod) muyeso yotsutsana ndi mavairasi, mankhwala osokoneza bongo omwe akhala akugwira ntchito kwa zaka zoposa 30. Zaphunziridwa ngati njira yothetsera matenda osiyanasiyana, kuphatikizapo matenda odwala matenda a Edzi (CFS kapena ME / CFS ), HIV / AIDS , mitundu ina ya khansa , chiwindi cha avian ndi nkhumba (H1N1) , ndi Ebola .
Mu 2009 komanso kachiwiri mu 2013, a FDA anakana Ampligen monga mankhwala ME / CFS.
Ichi chikanakhala chithandizo chovomerezeka choyamba cha matendawa komanso kupereka chitseko cha ampligen kumsika. Ngakhale zolephera izi, wopanga akupitirizabe kupita patsogolo kuti adziwe mankhwalawa.
Kodi Ampligen Amagwira Ntchito Bwanji?
Ampligen amakhulupirira kuti amagwira ntchito mwa kudumphira-kuyamba thupi lanu lachilendo chotsutsana ndi tizilombo ndikuyendetsa masewera a RNase L (chinthu chomwe chimayambitsa ma ARV), chomwe chingakhale chachikulu mwa anthu omwe ali ndi ME / CFS. Amasonyezanso kuti amaletsa kukula kwa maselo.
Ampligen samawoneka kuti amaletsa chitetezo cha mthupi. M'malo mwake, amakhulupirira kuti kusintha momwe thupi lanu limagwirira ntchito.
Ampligen ya Kutopa Kwambiri Kwambiri Syndrome
M'mayesero am'chipatala, Ampligen yasonyezedwa kuti ayambe kumvetsetsa, kupirira zolimbitsa thupi, thanzi la matenda a ubongo ndi ntchito yonse kwa anthu omwe ali ndi ME / CFS; kuchepetsa ntchito ya HHV-6 (kachilombo koyengedwa kuti ikugwirizana ndi ME / CFS), ndi kuchepetsa ntchito ya RNase L.
Malinga ndi opanga Ampligen, Hemispherx Biopharma Inc., madokotala oposa 40,000 a Ampligen anapatsidwa kwa odwala pafupifupi 500 m'mayesero a zamankhwala pazipatala zoposa 20 za ku United States. Chimodzi mwa zipatala zimenezi, Hunter-Hopkins Center, akuti odwala 80 peresenti amakula bwino pa Ampligen, ndipo 50% amakula kwambiri.
Chifukwa chakuti Ampligen saloledwa kugwiritsa ntchito iliyonse ku US, makliniki okha omwe ali ndi chilolezo chapadera angathe kupereka Ampligen. Zimalinso zodula kwambiri - monga zoposa $ 40,000 pachaka! Ndipo ayi, inshuwalansi yanu siidzaliphimba, chifukwa ndiyesa.
Ampligen imakhalanso yosagonjetsedwa mu European Union, koma odwala ena kumeneko akhoza kuzilandira kudzera mu zomwe zimatchedwa "pulogalamu yoyamba yofikira."
Ampligen Mlingo
Ampligen imayendetsedwa mwachindunji (IV). Mu mayesero komanso pansi pa zilolezo za FDA, odwala ambiri alandira 400mg ya mankhwala kawiri pa sabata. Hunter-Hopkins amalimbikitsa miyezi 12 ya mankhwala ndi miyezi 18 kwa odwala kwambiri.
Ampligen Side Effects
Monga mankhwala aliwonse, Ampligen angayambitse zotsatira zosafunika. Zotsatira zake zingakhalepo:
- Kuthamanga pang'ono,
- Kulimba kwa chifuwa,
- Kukwapula kofulumira,
- Nkhawa,
- Kupuma pang'ono,
- Kumverera wotentha,
- Kukwapula,
- Nausea,
- Matenda a enzyme ya chiwindi amasintha,
- Kutsekula m'mimba,
- Kuyabwa,
- Kuthamanga kwa magazi,
- Rash,
- Arrhythmias,
- Kuchuluka kwa maselo oyera a magazi,
- Chizungu,
- Kusokonezeka.
Odwala ena ali ndi zizindikiro za chimfine kwa maola angapo atalandira mlingo wa mankhwala. Wopanga amanena kuti zotsatirazi zimapita patatha miyezi yambiri ya chithandizo.
Zotsatira:
Smith ME, ndi al. Zambiri za mankhwala amkati. 2015 Jun 16; 162 (12): 841-50. Chithandizo cha myalgic encephalomyelitis / matenda otopa matenda: kuwonetseratu mwatsatanetsatane kwa National Institutes of Health Pathways to Prevention Workshop.
Strayer DR, et al. PLoS One. 2012; 7 (3): e31334. Kachilombo kawiri khungu, kosaoneka bwino, kosavuta, kachipatala ka TLR-3 agonist rintatolimod m'mavuto akuluakulu odwala matenda otopa.
Strayer DR, et al. Matenda opatsirana pogonana. 1994 Jan 18 Kuwonjezera 1: S88-95. Chiyeso chowongolera kuchipatala chokhala ndi RNA mankhwala, poly (I) .poly (C12U), mu matenda aakulu.
Suhadolnik RJ, et al. Mu vivo. 1994 Jul-Aug; 8 (4): 599-604. Kusintha kwa njira ya 2-5A sythetase / RNase L njira yowiritsa tizilombo mu mayesero ochiritsidwa a zachipatala ndi poly (I) -poly (C12U) mu matenda osatopa.