Estrogen ndi hormone yaikulu yomwe imapangidwa ndi mazira ochuluka komanso ochepa kwambiri ndi adrenal glands, ndipo imayambitsa zochitika za kugonana kwa akazi. Estrogen imafunika kuti chitukuko choyenera cha ziwalo zogonana chikhale bwino, kukonzanso kachilombo ka HIV, kayendedwe ka kusamba ndi kusamalira mimba.
Pa nthawi ya kusamba, estrogen imadziwika ndi mazira omwe akukula omwe amawoneka ndi mazira ndi kutukumula kwa endometrium chifukwa cha ovulation komanso kutenga mimba.
Komanso chimodzi mwa mahomoni akuluakulu a mimba, estrogen imathandizira kupanga madzi m'zigawo zoberekera zomwe zimapangitsa kuti umuna ukhalepo mwa kuchepetsa kuchepa kwa chiberekero. Chakumapeto kwa mimba, estrogen imalimbikitsa kukula kwa mkaka wa mkaka mkati mwa mawere ndipo imapangitsa kuti prolactin (hormone yaikulu yomwe imayambitsa lactation yazimayi) iwonongeke.
Synthetic Estrogen
Estrogen ndiyenso hormone yaikulu yomwe imapezeka mu mapiritsi oletsa kubereka s. Mapiritsi aliwonse ali osiyana, omwe ali ndi maselo osiyanasiyana a estrogen ndi / kapena progesterone .
Monga mkazi wa zaka ndipo amalowa Kutha Kwambiri, magulu ake a estrogen amayamba kuchepa. Pachifukwachi, madokotala ena angapereke mankhwala othandizira athereni, kuti athe kuchepetsa zizindikiro zina.
Estrogen Dominance mu Akazi ndi PCOS
PCOS ndi chifukwa chachikulu chomwe chimapangitsa kuti mwana asatengeke ndipo amakhulupirira kuti estrogen ikulamulira, ndilo chifukwa chake.
Kuperewera kwa ovulation kumabweretsa kuwonjezereka kwa estrogen ndi progesterone yosakwanira. Popanda kutsutsidwa ndi progesterone, kutsekula kwa estrogen nthawi zonse kungapangitse endometrium kukhala yowonjezereka kwambiri, zomwe zingayambitse magazi ochuluka komanso / kapena osasinthasintha.
Kwa zaka zambiri, khansara ya m'magazi ikhoza chifukwa cha kupititsa patsogolo kwa maitiro a estrogen osatsutsika ndi progesterone, zomwe zimayambitsa uterine mipiringidzo kuti isawonongeke bwino.
Kusamba Kwambiri Kwambiri Kudula ndi POSP
Kwa amayi omwe ali ndi menorrhagia (kutalika kwa nthawi yaitali kapena kuchepa kwa msambo), kuyang'anira kwa estrogen kungalimbikitsidwe kuti asiye kutuluka kwa magazi ndikukhazikitsa batala la endometrial. Mwinanso, progestins ingaperekedwe pamlomo kuti ayese kukwaniritsa gawo lodzidzidzidwa mwazi. Mankhwala ochepetsa kumwa mankhwala ammimba kapena intrauterine zipangizo (IUD) monga Mirena (njira yotulutsa levonorgestrel-yotulutsa intrauterine) ndi njira zothandizira kuchepetsa kutaya magazi. Nthaŵi zina, kupuma kwa endometrial, njira yopaleshoni yomwe imachotsa mapulogalamu ambiri, ikulimbikitsidwa.
Zomwe Zingayambitse Mavuto a Estrogen Kulamulira
Ngakhale kuti miyendo ya estrojeni yapamwamba komanso kusowa kwa progesterone ndizofunika kwambiri kuti maestrogen azilamulira kwambiri amayi omwe ali ndi PCOS, zinthu zachilengedwe zingathandizenso. Mankhwala m'dera lathu, otchedwa xenoestrogens , amatha kufanana ndi maselo otchedwa estrogen m'thupi mwathu ndikuchita zinthu zosokoneza.
Zina mwa magwero a mapuloteni otchedwa endocrine amaphatikizapo mankhwala ophera tizilombo, Bisphenol A (BPA) ndi phthalates (omwe amapezeka mu mapulasitiki, mabotolo a madzi, ndi mapepala a mapepala), ndi ma parabens (omwe nthawi zambiri amapezeka m'magulu a chisamaliro ndi tsitsi).
Zimaganizidwa kuti BPA imasokoneza njira zowonetsera, mwinamwake mwa kulepheretsa ovomerezeka ndi estrogen. Mipingo ya BPA yasonyezedwa mu maphunziro kuti akhale apamwamba mwa amayi omwe ali ndi PCOS.
Pochepetsa kuchepetsa kusokoneza zachilengedwe, tsatirani malangizo awa:
- Sankhani magalasi kuti mugenthe ndi kusunga chakudya
- Imwani zakumwa kuchokera m'mabotolo a magalasi kapena zolembedwa "BPA-free"
- Gulani katundu wamakina wolembedwa "BPA-wopanda"
- Kudya zakudya zachilengedwe ndi "zakudya zopanda mahomoni"
- Sambani manja bwino mutatha kulandira mapepala a mapepala
- Fufuzani zosakaniza m'magulu a chisamaliro cha tsitsi ndi tsitsi, kugula "opanda pake" m'malo mwake
- Kuwonjezera pamenepo, kudya chakudya chokhala ndi antioxidants kungathandizenso kuteteza maselo otchedwa estrogen kuwonongeka kwa chilengedwe.
Yosinthidwa ndi Angela Grassi, MS, RDN
Zotsatira
Kuchetsa kwachiberekero kosazolowereka: Chitsogozo cha Odwala. American Society of Reproductive Medicine Chidziwitso Chowonadi chinafika pa June 8, 2015 http://www.reproductivefacts.org/BOOKLET_abnormal_uterine_bleeding/
Barrett ES1, Sobolewski M2. Matenda a Polycystic ovary: kodi mankhwala osokoneza bongo amathandiza kwambiri? Semin Reprod Med. 2014 May; 32 (3): 166-76.