Ntchito yosadziwika ya mahomoni imakhudza amai ndi abambo onse
Hyperprolactinemia ndi chikhalidwe cha mahomoni omwe amatchedwa prolactin m'magazi. Prolactin imapangidwa ndi ntchentche ya pituitary ndipo imawathandiza kwambiri pakukula mawere pa nthawi ya mimba.
Ngakhale kuti hyperprolactinemia imaonedwa ngati yachilendo pa nthawi ya mimba ndi kuyamwa, ikhoza kuchitika nthawi zina chifukwa cha matenda ndi kugwiritsa ntchito mankhwala.
Mankhwala a hyperprolactinemia angakhudze amayi ndi abambo onse, zomwe zimapangitsa kuti asakhalenso ndi nthawi yosiya kusamba komanso erectile.
Zifukwa za Hyperprolactinemia
Mabala a prolactin akhoza kukhala okwera pa zifukwa zingapo. Chimodzi mwa zifukwa zofala kwambiri ndi kupanga chotupa chochititsa manyazi pamtenda wa pituitary. Kukula kosakanikirana kumeneku, komwe kumatchedwa prolactinoma, kumatulutsa mwachindunji prolactin mochulukirapo pamene kuchepetsa miyeso ya mahomoni ena achiwerewere.
Matenda okhudza mbali ya ubongo yotchedwa hypothalamus ikhoza kuyambitsa hyperprolactinemia. The hypothalamus ikugwira ntchito monga mgwirizano pakati pa dongosolo la mitsempha ndi chifuwa cha pituitary. Kuwonjezeka kwa ma prolactin nthawi zambiri kumagwirizana kwambiri ndi chotupa, zowawa, kapena matenda a hypothalamus.
Zifukwa zina zingaphatikizepo:
- Hypothyroidism (kuchepa kwa mahomoni a chithokomiro)
- Cirrhosis ya chiwindi
- Kulephera kwa impso
- Matenda oletsa kupanikizika (Anafranil, Norpramin)
- Antipsychotics (Haldol, Zyprexa, Risperdal)
- Antihypertensives ( Verelan, Calan, Covera-HS, Isoptin)
- Antinauseals (Reglan, Primperan, Lexapram)
- Acid H2 blockers (Tagamet, Zantac)
- Estrogen
Zizindikiro za Hyperprolactinemia
Zizindikiro za hyperprolactinemia kwa amayi zimasiyana. Mukapezeka kunja kwa mimba kapena kuyamwitsa, iwo angaphatikizepo:
- Kusadziletsa
- Gallactoria (lactation osadziwika)
- Nthawi zosavuta kapena zosasintha
- Amenorrhea (nthawi yochepa ya ovulation)
- Kutaya kwa libido
- Kupweteka kwa m'mimba
- Zowawa zogonana chifukwa cha zowuma
Pamene zikuchitika mwa amuna, zizindikirozo zimakhudza kugonana kosayenera ndi / kapena kupweteka kumene kumayambitsa mapangidwe a prolactinoma. Zizindikiro ndi zizindikiro zimaphatikizapo:
- Kusokonekera kwa Erectile
- Gynecomastia (kukula kwa mawere a m'mawere)
- Kugwirizana
- Kusadziletsa
- Kutaya kwa libido
Chifukwa chakuti hyperprolactinemia mwa amuna sichiwonetsa nthawi zonse ndi zizindikiro zowonjezereka, monga vuto la kusamba, nthawi zina zimakhala zovuta kuziwona. Nthawi zina, kupweteka kwa mutu kumayambitsa chifuwa chachikulu kapena kusintha m'masomphenya kungakhale chizindikiro choyamba cha chikhalidwe cha amuna ndi akazi.
Kuzindikira kwa Hyperprolactinemia
Kupezeka kwa hyperprolactinemia kumaphatikizapo kuyesa magazi nthawi zonse kuti ayang'ane ma prolactin. Ngati m'magazi akukwera, dokotala angafune kubwereza mayesero, nthawi ino atatha kudya kwa maola asanu ndi atatu. Mawere a prolactin ochepa amakhala osachepera 500 mI / L kwa amayi ndi osachepera 450 mIU / L kwa amuna
Kujambula kwa magnetic resonance (MRI) kungayesedwe kuti ayang'ane umboni wa kukula kwa chiwopsezo kapena kuwonongeka kwa matenda ozungulira.
Mayeso a magazi poyesa mazinga ena a hormone angakhale othandiza polamulira zina zomwe zingayambitse zizindikiro.
Kuchiza kwa Hyperprolactinemia
Cholinga cha chithandizo ndi kubwezeretsa prolactin kumagulu abwino. Pali njira zingapo zomwe mungakwaniritse izi:
- Mankhwala a Parlodel (bromocriptine) ndi Dostinex (cabergoline) amadziwika kuti amathandiza kuchepetsa ma prolactin ndi kuchepa kwa matumbo.
- Nthaŵi zina opaleshoni ingagwiritsidwe ntchito kuchotsa chotupa cha mankhwala ngati mankhwala sakugwira ntchito kapena sakulekerera
- Maizoni, pamene sagwiritsidwa ntchito mobwerezabwereza, angapangidwe ngati mankhwala ndi opaleshoni sizinagwire ntchito.
- Hysyothyroidism imatha kuchiritsidwa ndi mahomoni otchedwa thyroid, omwe ayenera kubweretsa ma prolactin.
- Ngati miyezo yapamwamba ya prolactin imayambitsidwa ndi mankhwala osokoneza bongo, mankhwala olowa mmalo amatha kulembedwa.
> Chitsime:
> Melmed, S .; Casanueva, F .; Hoffman, A. et al. "Kuzindikira ndi Chithandizo cha Hyperprolactinemia: An Endocrine Society Guide Practice Practice." Journal of Clinical Endocrinology ndi Metabolism. 2011; 96 (2): 272-88.