Kusuntha, kulingalira, ndi luso lamagetsi zimakhudzidwa kwambiri
Primary Primary Multiple sclerosis (PPMS) imakhudza anthu ambiri mwa anthu asanu ndi atatu omwe amakhala ndi multiple sclerosis. Pa mitundu yosiyanasiyana ya matendawa , PPMS imatengedwa kuti ndi yovuta.
Momwe PPMS Imasiyanirana ndi Mafomu Ena a MS
Fomu yofala kwambiri, yomwe imadziwika kuti relapsing-remitting MS (RRMS) , imadziwika ndi ziwawa zoopsa zomwe zimachitika nthawi yomwe matendawa sapita patsogolo.
Pamene iyo ikupita patsogolo, munthu akuti ali ndi gawo lachiwiri (SPMS) .
PPMS, mosiyana, ikupita patsogolo kuyambira pachiyambi. Munthu amene amapezeka ndi PPMS alibe maulamuliro omwe amabwereranso ndi RRMS kapena SPMS. M'malo mwake, zizindikiro zimadza pang'onopang'ono ndipo sizingasinthe.
Mofanana ndi mitundu ina ya multiple sclerosis, njira ya PPMS ndi yosiyana kwambiri, yomwe imakhudza munthu aliyense mosiyana. Ena angakhale olumala mkati mwa zaka zingapo pamene ena amakhalabe olimba kwa zaka zambiri.
Zizindikiro zogwirizana ndi Mtsempha Wamphepete
Malinga ndi zizindikiro, anthu omwe amapezeka ndi PPMS nthawi zambiri amakumana ndi mavuto chifukwa cha kupita patsogolo kwa atrophy (kupasuka ndi kutaya) kwa msana. Amatchedwanso kuti myelopathy yopitirira, zizindikiro zingaphatikizepo:
- Kuwonjezereka kwapadera komwe kumatchulidwa kuti spastic paraparesis, kumene miyendo idzayamba kuumitsa, kuchititsa kuoneka kosaoneka ndi / kapena kumveka mwamphamvu
- Kufooka kapena kutayika pambali imodzi ya thupi, yotchedwa spastic hemiparesis , yomwe ingakhudze miyendo, mikono, kapena manja
- Kusamvetsetsana (kuchepa kukwanitsa kuchita masewero olimbitsa thupi)
- Kudandaula ndi kusowa kwa minofu ( ataxia )
Pamene msana umakhudzidwa ndi matendawa, ukhoza kusokoneza zambiri kuposa kungoyenda.
Zingayambitse kupweteka kwa kugonana, chikhodzodzo, ndi matumbo. Kutopa kumakhalanso kofala ndi izi ndi mitundu yonse ya multiple sclerosis.
Zizindikiro zogwirizana ndi ubongo
Ngakhale kuti msana wamphaka ndiwo cholinga chachikulu cha kuvulala mu PPMS, ubongo ungasokonezedwe, makamaka mbali yomwe imadziwika kuti cerebellum yomwe imayendetsa bwino ndi kugwirizana. Matendawa amadziwika kuti ndi matenda a cerebellar (PCS), vutoli limakhudza munthu mmodzi mwa anthu khumi alionse omwe ali ndi PPMS ndipo amatha kuwonekera ndi:
- Kusokonezeka kwa kayendetsedwe kabwino ka dzanja chifukwa cha chivomezi champhamvu
- Kutaya minofu (hypotonia)
- Kutaya malire (gait ataxia)
- Kulephera kuyendetsa kayendetsedwe kake (dysmetria) komwe munthu amawongolera kapena kutsogolera malo omwe manja, mwendo, kapena dzanja
- Kulephera kuyendetsa kayendetsedwe kake kachitsulo ( dysdiadochokinesia ) kupopera kotere mu babu
Kutupa ndi kuwonongeka kwa mpweya kumaoneka ngati njira zazikulu zomwe zimayambitsa matenda a cerebellar ndi kugwidwa kwa msana m'magulu a PPMS.
Zizindikiro zosadziwika za PPMS
Ngakhale kuti sichidziwikiratu, PPMS ingakhudze mbali zina za mitsempha ya ubongo monga ubongo wa ubongo (womwe uli pakati pa ubongo ndi khosi la msana) ndi ubongo (thupi lalikulu la ubongo).
Zizindikiro zikuwonetsedwa peresenti yokha ya anthu omwe ali ndi PPMS koma angaphatikizepo:
- Mavuto ndi kumeza ( dysphagia )
- Umaliseche, kusanza, kapena mseru
- Mofulumira, kusuntha kosasamala kwa maso ( nystagmus )
- Kusokonezeka kwa masomphenya kapena kutayika
- Kulephera kuzindikira zamaganizo , kuphatikizapo kusowa kwa kukumbukira, kulingalira nthawi, mawu omveka bwino, kapena kulingalira kwa malo
Mawu Ochokera
Mpaka posachedwa, panalibe mankhwala omwe amapezeka kuti athetse PPMS. Mankhwala osokoneza bongo, monga Rebif ndi Copaxone, amagwira ntchito makamaka pochepetsa kuchepa kwa RRMS, koma atsimikiziridwa kuti sagwira ntchito pochiza mtundu wa mitsempha ya m'magazi yomwe imapezeka mu PPMS.
Mwamwayi, zinthu zasintha. Tsopano tili ndi mankhwala otchedwa Ocrevus (ocrelizumab) omwe amatha kulandira PPMS komanso kubwezeretsanso mitundu ya matendawa. Ovomerezedwa ndi US Food and Drug Administration (FDA) mu March 2017, Ocrevus amaonedwa kuti ndimasintha kwambiri masewera ndipo angasinthe miyoyo ya iwo omwe amakhala ndi mawonekedwe osadziwika a multiple sclerosis.
> Zosowa
> Ohrbach, R .; Zhao, A .; Wang, Y. et al. "Kuyerekezera Matenda a Ntchito mu SPMS ndi PPMS mu Chiganizo cha Multicenter Clinical Trials." PLoS One 2012; DOI 10.1371 / journal.pone.0045409.
> Utsogoleri wa US Food and Drug Administration. "Ocrevus (ocrelizumab) Injecting." Silver Spring, Maryland; March 28, 2017.