Gulu la Kusokonezeka Limayambitsa Kusamalitsa Kwambiri
Episodic ataxia ndi vuto lachilendo lomwe limakhalapo nthawi yomwe munthu sangathe kuyendetsa kayendedwe ka thupi ( ataxia ). Pali mitundu eyiti ya episodic ataxia, koma awiri oyambirira ndi odziwika kwambiri.
Episodic Ataxia mtundu woyamba
Maselo osasunthika omwe amayamba chifukwa cha episodi ya ataxia mtundu wa 1 (EA1) nthawi zambiri amakhala kwa mphindi imodzi pokha. Nthawizi nthawi zambiri amabweretsedwa ndi masewera olimbitsa thupi, caffeine, kapena nkhawa.
Nthawi zina pangakhale kusokonezeka kwa myokymia yomwe imafika ndi ataia. Zizindikiro zimayamba nthawi yaunyamata.
Episodic ataxia mtundu wa 1 amayamba chifukwa chosinthika mu njira ya ion potassium. Kawirikawiri njirayi imalola kuti magetsi awonetseke m'maselo a mitsempha, ndipo zizindikirozi zingakhale zachilendo pamene njirayo imasinthidwa ndi kusintha kwa chibadwa. Njira yosavuta yoyesera EA1 ndiyo kupeza mayeso achibadwa. MRI ingachitidwe pofuna kutulutsa zifukwa zina zomwe zingayambitse ataxia, koma pa EA1, MRI iwonetsa pang'ono shrinkage pakati pa cerebellum yomwe imatchedwa vermis.
Episodic Ataxia mtundu 2
Episodic ataxia mtundu wa 2 (EA2) umagwirizanitsidwa ndi zigawenga zowopsa kwambiri ndipo nthawi zina kusambidwa ndi kusanza komwe kumatenga maola ndi masiku. Nystagmus, vuto limene maso amayenda mobwerezabwereza komanso mosalekeza, sangakhalepo panthawi yokha komanso pakati pa ziwonongeko. Mosiyana ndi EA1, episodic ataxia mtundu 2 akhoza kuvulaza cerebellum, mbali ya ubongo yoyenera kugwirizanitsa.
Chifukwa cha kuwonongeka kwapang'onopang'ono kumeneku, anthu omwe ali ndi EA2 amatha kutaya mwadzidzidzi minofu pakati pa zochitika zawo nthawi ndi nthawi. Mofanana ndi EA1, anthu omwe ali ndi EA2 nthawi zambiri amamva zizindikiro zaunyamata.
Episodic ataxia mtundu 2 amayamba chifukwa cha kusintha kwa kashiamu. Njira imeneyi ya calcium imasinthidwanso mu matenda ena monga spinocerebellar ataxia mtundu wa 6 ndi banja hemiplegic migraine .
Anthu ena omwe ali ndi EA2 ali ndi zizindikiro zomwe zimakumbukira matenda ena.
Zolemba Zina za Ataxias
Zotsalira za episodic ataxia, mitundu EA3 kudzera mu EA8, ndizochepa. Zambiri zosaoneka bwino za atxicia ndizooneka ngati zofanana ndi EA1 ndi EA2 koma zimakhala ndi kusintha kwa mitundu yosiyanasiyana monga chifukwa. Aliyense wa subtypeswa wafotokozedwa m'banja limodzi kapena awiri okha.
- EA3 akutsutsa mwachidule za kuchepa kwa minofu ndi kulamulira, ndi chizungulire ndi kupweteka kwa minofu.
- EA4 ali ngati EA2, ali ndi kayendedwe kodabwitsa ka maso ngati nyamakazi yomwe imapitirizabe ngakhale kuti palibe vuto lililonse, ngakhale kuti ziwonongeko ndizochepa. EA4 ndi yapadera chifukwa sichiyankhidwa bwino ndi mankhwala omwe amagwiritsidwa ntchito kwa ena episodic ataxia.
- EA5 ikuukira zomwe zikuchitika kwa maola monga EA2. Zakhala zikufotokozedwa m'banja lachi French ku Canada.
- EA6 imayambitsidwa ndi kusintha kwa thupi komwe kungagwirizanenso ndi kupweteka , migraine , ndi hemiplegia , kachiwiri monga EA2.
- EA7 inadziwika mu banja limodzi lokha ndipo ili ngati EA2 kupatula kuti kuyesa kwa mitsempha kwachibadwa kumakhala pakati pa zotsutsana.
- EA8 imasonyeza zizindikiro zake kuyambira ali wakhanda ndi ziwonongeko zokhalapo mphindi zochepa mpaka tsiku lonse. Zapezeka mu banja limodzi ndikuyankha clonazepam.
Kusanthula kwa Episodic Ataxia
Asanafike pozindikira kuti matenda osoŵa kwambiri monga episodic ataxia, zifukwa zina zomwe zimachititsa kuti athaia ayambe kuyendera ayenera kufufuzidwa. Komabe, ngati muli ndi mbiri yeniyeni ya ataxia, zingakhale zofunikira kupeza mayeso a majini.
Ambiri amachilendo amalimbikitsa kugwira ntchito ndi aphungu pazomwe akufuna kuyesa mtundu uwu. Ngakhale kuti zotsatira za mayeso a chibadwa zingawoneke mosavuta, nthawi zambiri mumakhala zovuta zamtundu uliwonse zomwe zingasamalidwe. Ndikofunika kudziŵa kuti mayeso a majini amatanthauza chiyani kwa inu komanso banja lanu.
Chithandizo
Zizindikiro za EA1 ndi EA2 zimapangidwira ndi acetazolamide, mankhwala amene amagwiritsidwa ntchito ngati diuretic kapena kuthandiza kusintha ma asidi m'magazi.
Dalfampridine yasonyezedwanso kuti ili yogwira ntchito pa episodic ataxia mtundu wachiwiri. Thandizo la thupi lingakhale lothandiza kuthetsa ataxia pamene ilipo.
Ngakhale episodic ataxia si yachilendo, matendawa amathandiza kwambiri odwala komanso banja lawo. Ndikofunika kwa akatswiri a zachipatala ndi odwala kuti aganizire za episodic ataxia pamene pali mbiri ya banja lachisokonezo.
Zotsatira:
> Choi KD, Choi JH. Episodic Ataxias: Zomwe amagwiritsa ntchito pazipatala komanso m'magazi. Journal of Trouble Movement . 2016; 9 (3): 129-135. lembani: 10.14802 / jmd.16028.
> Strupp M, Kalla R, Claassen J, et al. Kuyesedwa kosawerengeka kwa 4-aminopyridine mu EA2 ndi maukwati omwe amacheza nawo pamsosi akaxia. Neurology 2011; 77: 269.