Kodi Zakudya Zopanda Gluten Zingathandize Bwanji Matenda a Lou Gehrig?
Anthu ena omwe ali ndi mantha a m'maganizo a amyotrophic lateral sclerosis - omwe amadziwika kuti ALS, kapena matenda a Lou Gehrig - ali ndi mphamvu yambiri ya anti-gluten yomwe imayenda m'matupi awo, akukambirana ngati zakudya zopanda thanzi zingathandize pakuchiza matendawa, phunziro likuwonetsa.
Komabe, ofufuza omwe adachita phunzirolo adachenjeza kuti zomwe adapezazo ndizoyambirira ndipo ziyenera kutsimikiziridwa ndi kufufuza kosavuta pamaso pa madokotala kuti asamalire odwala awo ALS ndi zakudya zopanda thanzi.
Asayansi, omwe amapezeka ku Tel Aviv Medical Center ku Israel, pakalipano akuyesa kufufuza zochitika zomwe zimawathandiza kuti asamakhale ndi matenda a ALS omwe ali ndi ma antibodies kuti akhale ndi gluten.
"Deta yochokera ku phunziroli ikusonyeza kuti, nthawi zina, matenda a ALS angagwirizane ndi autoimmunity ndi gluten kumva mphamvu," ochita kafukufuku analemba m'bukuli, mu April 2015 m'nyuzipepala ya zachipatala JAMA Neurology . "Ngakhale kuti deta ili yoyamba ndipo ikufunika kubwereza, kutengeka kwa gluten kumatha kuchiza; choncho, vutoli lakudziwitsa siliyenera kunyalanyazidwa."
Kuchiza kwa ALS Kungakhale Kofunika Kwambiri
ALS ndi matenda opatsirana a m'magazi omwe amatha kuwatsatira - kawirikawiri mkati mwa zaka zingapo za matenda - mu ziwalo ndi imfa. Anthu pafupifupi 5,600 amapezeka ndi ALS chaka chilichonse ku US, ndipo vutoli ndilofala pakati pa zaka 40 ndi 60. Matendawa amachititsa kuti msana ugwedezeke.
Mwinamwake mukudziŵa bwino za chikhalidwe chomwe chimachitika mu chilimwe cha 2014 ndi Challenge ya ALS Ice Bucket Challenge, yomwe idagwidwa ndi mafilimu owonetsera zachilengedwe ndipo inaletsa ndalama zoposa $ 100 miliyoni kuti zithandizire ndi kufufuza za ALS.
Kupeza chithandizo cha ALS chomwe chimathandiza anthu ena kusintha - ngakhale ngati chithandizochi chikugwiritsidwa ntchito pang'onopang'ono kwa omwe ali ndi ALS - zingakhale zofunikira.
Pakalipano, pali mankhwala amodzi omwe amavomerezedwa ku ALS, ndipo mankhwala amachititsa kuti pang'onopang'ono zizindikiro za zizindikiro ziziyenda bwino pothandizira odwala kusamalira bwino zizindikiro zawo.
Ino si nthawi yoyamba imene madokotala awonetsera kugwirizanitsa pakati pa matenda a leliac ndi / kapena mphamvu zamtundu wa gluten komanso ALS. Nkhani ziwiri zofalitsidwa m'magaziniyi zimalongosola odwala omwe poyamba amapezeka kuti ali ndi ALS, koma pambuyo pake anapezeka kuti ali ndi matenda a celiac ndipo amene amayamba kudwala matendawa asanakwere.
Komabe, kufufuza kwakukulu kofalitsidwa mu 2014 kunalephera kupeza mgwirizano uliwonse pakati pa matenda a leliac, makamaka, ndipo kenako anapeza ALS.
Kuphunzira kwa Tel Aviv Kumayang'ana Matenda Achilendo Osadziwika
Kafukufuku waposachedwapa kuchokera kwa ochita kafukufuku wa ku Israeli anaphatikizapo odwala 150 ALS omwe anapeza kuti akutsatirana pakati pa July 2010 ndi December 2012, kuphatikizapo 115 zowonongeka.
Ochita kafukufuku anayeza magazi kuti awononge matenda a gluten omwe amagwirizana ndi matenda a leliac ndipo anapeza kuti palibe aliyense mwa anthu omwe ali ndi magulu ena omwe ali ndi ma antibodies, kutanthauza kuti iwo alibe matenda a celiac.
Ofufuzawo anafunanso mtundu wina wa anti-gluten wotchedwa IgA-Transglutaminase-6 (IgA-TG6), umene suli ndi matenda a celiac.
Komabe, IgA-TG6 imagwirizanitsidwa m'maphunziro ena ku gluten ataxia , chikhalidwe chokhachokha cha thupi chomwe thupi limayankha kugwiritsiridwa ntchito pogwiritsa ntchito neurons. Gluten ataxia ingabweretse kuumphawi waukulu, wopita patsogolo pa milandu yoopsa.
Phunzirolo linapeza kuti odwala 23 ALS - kapena 15.3% - anali ndi ma antibodies apamwamba a IgA-TG6, poyerekeza ndi 4.3% zokhazokha. Kuwonjezera apo, pafupifupi 59% mwa odwala ALS omwe ali ndi ma antibodies a gluten amanyamula chimodzi mwa majini a matenda a leliac .
Odwala a ALS omwe anali ndi ma antibodies a IgA-TG6 omwe amayenda m'magazi awo amasonyeza zomwe gululi limatcha "zithunzi zachilendo za ALS," zofanana ndi odwala ALS opanda magulu a anti-gluten - mwazinthu, madokotala sakanatha kuwauza magulu awiriwo .
Nanga Zonsezi Zikutanthauzanji?
Izi siziri bwino panobe. Monga momwe ndalembera pamwambapa, ofufuza omwe akupezeka mu phunziro lino adawachenjeza kuti asamawerenge kwambiri, ngakhale kuti akuyesera kuti sangakhale ndi gluten angathandize opaleshoni ya ALS, makamaka mu chigawo cha anthu omwe ali ndi ma antibodies awa a IgA-TG6.
Ngati zofukufuku zawo zikuphatikizidwa, chotsatira chotsatira ndichokakhala kuyesa kuyezetsa kachipatala kuti muone ngati zakudya zopanda thanzi zingapindule odwala onse a ALS ndi IgA-TG6. Mapulani a phunziro lotero akuchitika. "Kafukufuku wathu akusonyeza kuti matenda a ALS okhudzana ndi kupweteka kwa gluten amapezeka m'gulu la odwala komanso kuti TG6 IgA autoantibodies ikhoza kukhala chizindikiro cha odwala omwe ali ndi vuto la gluten."
Zotsatira:
Brown KJ et al. Zilonda zazungu zoyipa za amyotrophic lateral sclerosis chifukwa cha matenda a celiac. American Journal of Neuroradiology . 2010 May; 31 (5): 880-1.
Gadoth A et al. Antiglutaminase 6 Antibodies mu Seramu ya Odwala Ndi Amyotrophic Lateral Sclerosis. JAMA Neurology . Lofalitsidwa pa Intaneti April 13, 2015.
Ludvigsson JF et al. Palibe mgwirizano pakati pa matenda oopsa omwe ali otsimikiziridwa ndi biopas komanso matenda omwe amachititsa kuti anthu asamangokhalapo. European Journal of Neurology . 2014 Jul; 21 (7): 976-82.