Matenda a Makhalidwe Abwino
Matenda a Leigh ndi matenda omwe amachititsa kuti thupi lisokonezeke (ubongo, msana, ndi mitsempha ya optic). Matenda a Leigh amayamba chifukwa cha mitochondria, malo opangira mphamvu m'maselo a thupi.
Matenda a chibadwa omwe amachititsa matenda a Leigh akhoza kulandira njira zitatu. Zingakhale zochokera ku chromosome X (chachikazi) monga chibadwa chosowa cha puloteni yotchedwa pyruvate dehydrogenase complex (PDH-Elx).
Zingatengedwe monga chowongolera chodzidzimutsa chomwe chimakhudza msonkhano wa puloteni wotchedwa cytochrome-c-oxidase (COX). Zingathenso kulandira monga kusintha kwa DNA mu mitochondria.
Zizindikiro
Zizindikiro za matenda a Leigh nthawi zambiri zimayamba pakati pa miyezi itatu ndi zaka ziwiri. Popeza matendawa amakhudza dongosolo lalikulu la mitsempha, zizindikiro zingaphatikizepo:
- kuyamwa kosavuta
- vuto lokhala ndi mutu
- Kutaya mwayi wamagetsi mwana wakhanda amakhala ngati kugwidwa ndi kugwedeza
- kusowa kwa njala
- kusanza
- kukwiya
- kulira kopitirira
- kugwidwa
Pamene matenda a Leigh akuipiraipira m'kupita kwanthawi, zizindikiro zikhoza kukhala:
- kufooka kwathunthu
- kusowa kwa minofu (hypotonia)
- ma episodes a lactic acidosis (kuwonjezeka kwa lactic acid mu thupi ndi ubongo) zomwe zingawononge kupuma ndi impso ntchito
- mavuto a mtima
Kudziwa
Kuzindikira kwa matenda a Leigh kumadalira zizindikiro zomwe mwana kapena mwana ali nazo.
Mayesero angasonyeze kuperewera kwa pyruvate dehydrogenase kapena kupezeka kwa lactic acidosis. Anthu omwe ali ndi matenda a Leigh angakhale ndi zigawo zosiyana kwambiri za ubongo mu ubongo zomwe zingathe kudziwika ndi kufufuza kwa ubongo. Kwa anthu ena, kuyesedwa kwa majini kungathe kuzindikira kuti pali kusintha kwa chibadwa.
Chithandizo
Chithandizo cha matenda a Leigh chimaphatikizanso ma vitamini monga thiamine (vitamini B1). Mankhwala ena akhoza kuganizira za zizindikiro zomwe zilipo, monga mankhwala osokoneza bongo kapena mankhwala a mtima kapena impso. Kulandira thupi, kugwira ntchito, ndi kulankhula kungathandize mwana kukwaniritsa zomwe angathe.
Zotsatira:
> "NINDS ya Leigh's Disease Information Page." Kusokonezeka. 13 Feb 2007. bungwe la National for Neurological Disorders ndi Stroke.
> "Matenda a Leigh." Mndandanda wa Zachilombo Zambiri. 17 Dec 2007. bungwe la National Rare Disorders.
> Macnair, Trisha. Matenda a Leigh. BBC Health. July 2006.