Ngati inu kapena wokondedwa wanu mwapezeka posachedwapa ndi MS (SPMS), mukhoza kudabwa momwe katswiri wanu wa m'maganizo amatsimikizira zimenezi.
Mwinanso, mwakhala mukubwezeretsanso MS (RRMS) ndikudabwa momwe dokotala wanu adziwa (kapena ngati) mutembenuka kuchokera ku RRMS kupita ku SPMS.
Awa ndiwo malingaliro abwino, ndipo ngati munthu amakhala ndi MS , kumvetsa kusintha kwa matenda a MS n'kofunika.
Mwanjira imeneyi mumakhala okonzekera kwambiri za tsogolo lanu ndi mavuto amene mungakumane nawo.
Kuzindikira Kuwonjezeka Kwachiwiri Multiple Sclerosis
Multiple sclerosis (MS) ndi matenda opatsirana a ubongo omwe angakhale ovuta kuwunikira. Kachimodzi, zizindikiro zimatha kufanana ndi zina zaumoyo. Chachiwiri, palibe mayesero amodzi omwe amatsimikizira kuti ali ndi matenda. M'malo mwake, kupeza MS kumakhala ngati kusonkhanitsa pamodzi, ndipo nthawizina zidutswa sizigwirizana.
Zowonjezereka, kugwiritsidwa ntchito kwa MS kumaphatikizapo kuyika pamodzi kuphatikizapo umboni wofunikira (mwachitsanzo, zotsatira zochokera ku MRI kapena kupuma kwa lumbar ), kuphatikizapo chidziwitso chodziwika, monga mbiri ya munthu ya zochitika zamaganizo ndi kuunika kwa thupi.
Izi zanena kuti, ngati mukufuna kupeza kachilombo koyambitsa MS, dokotala wanu ayenera kulingalira njira ziwiri zofunika:
Khwerero 1: Tsimikizani Mbiri RRMS
Kutsimikizira mbiri ya kubwezeretsanso MS (chifukwa chake imatchedwa "chachiwiri") kungakhale kovuta, monga momwe anthu ena angapezere gawo la RRMS popanda kudziwa.
Mwinamwake iwo sanamvetsetse bwino kapena zizindikiro zawo zinali zonyenga, iwo sanawone ngakhale dokotala.
Khwerero 2: Onetsetsani kuti MS ndi Progressive
Mutatsimikizira mbiri ya RRMS, dokotala wanu ayenera kufotokozera momwe matenda anu alili "omwe amapita patsogolo," kapena kuti akupita patsogolo pang'onopang'ono.
Kuti mumvetse bwino zomwe "zopita patsogolo" zikutanthawuza, ndi kosavuta kuganizira zamoyo zonse za SPMS ndi chithunzi cha kliniki, kutanthauza kuti munthu yemwe ali ndi masewera a SPMS.
Biology ya SPMS
Mu RRMS, tikudziwa kuti chitetezo cha mthupi chimagonjetsa chitetezo cha myelin (chitetezo chozungulira kuzungulira mitsempha), ndipo ndondomekoyi imatchedwa kutaya thupi. Monga chiwalo cha myelin chimaonongeka kapena chiwonongeke, chizindikiro cha mitsempha sichikhoza kulumikizidwa bwino kuchokera mu ubongo ndi msana kwa thupi lonse.
Mmene chitetezo cha mthupichi chimayambira pamsana wa myelin ndi njira yotupa, monga zikuwonetsedwa ndi mawanga oyera (otchedwa gadolinium enhaning lesions ) omwe amawoneka mosiyana ndi MRIs panthawi yovuta.
Komabe, mu SPMS, pali kusintha kwakukulu kochepetsetsa m'katikati mwa manjenje. M'malo mwake, zizindikiro za SPMS ndizosauka kwa nkhani zakuda komanso zoyera ndi atrophy (kutayika kwa maselo a mitsempha), monga momwe zilili pa MRIs za ubongo ndi msana.
Ndipotu, atrophy ya msana wamphongo ndi wotchuka kwambiri mu SPMS kuposa RRMS ndi digiri ya atrophy correlates ndi momwe munthu wolumala alili. Pokhala ndi chingwe cha msana, anthu omwe ali ndi SPMS akhoza kukhala ndi mavuto ambiri akuyenda, komanso mavuto a chikhodzodzo ndi m'mimba.
Ndikofunika kumvetsetsa kuti kudakalibe kuchitika ku SPMS, koma kuli kofalikira, kusiyana ndi kuika patsogolo, monga mu RRMS. Komanso, pamene pali kutupa kopitirira komwe kumachitika mu SPMS, sizingakhale zolimba monga RRMS.
Kwenikweni, kuchepa kwa kutupa mu SPMS kumathandiza kufotokoza chifukwa chake anthu omwe ali ndi SPMS samakhala bwino ndi mankhwala ambiri ochiza matenda omwe amagwiritsidwa ntchito pochiza RRMS (omwe amachepetsa kuchepa).
Kuchipatala Chithunzi cha SPMS
Munthu amene ali ndi RRMS (omwe amapezeka kwambiri a MS) amakhala ndi zizindikiro kapena zozizwitsa (zotchedwa kubwereranso) za mavuto a mwadzidzidzi mwadzidzidzi.
Mwachitsanzo, chizoloŵezi choyamba chobwezeretsanso kachilomboka ndi optic neuritis , momwe mitsempha ya munthu (mitsempha yothandizira ubongo ku retina) imatha. Kuchokera kwa optic neuritis kumayambitsa zizindikiro monga ululu wa diso pa kayendetsedwe ka masomphenya ndi zovuta.
Ndi kubwezeredwa kulikonse, zizindikiro za thupi za munthu zimatha kuthetsa kwathunthu kapena mwinamwake.
Mwa kuyankhula kwina, pangakhalebe mavuto a ubongo akatha kubwerera, koma amakhala osasunthika ndipo saipiraipira (pokhapokha ngati kubwerera kwinakwake kumalo omwewo amachititsa).
Kumbali ina, mu MS patsogolo, munthu wa MS amatsata mofulumira, akuyipiraipira pa nthawi. Mwachitsanzo, munthu yemwe ali ndi SPMS angazindikire kuti kuyenda kwake kwafalikira pa miyezi isanu ndi umodzi yapitayi, koma sitingakumbukire tsiku kapena malo ena omwe nthawi yomweyo akuyenda mofulumira.
Nthawi Yosintha Pakati pa RRMS ndi SPMS
Mbali yowopsya ya SPMS ndi yakuti akatswiri tsopano akuzindikira kuti nthawi zambiri nthawi ya kusintha pakati pa nthawi imene RRMS imatha ndipo SPMS imayamba. Mwa kuyankhula kwina, chithunzi cha munthu chitha kugwirana pakati pa mitundu iwiri ya MS-kotero MS ya munthu akhoza kuwonjezereka pang'onopang'ono, pamene akubwezereranso apa ndi apo.
Zimene Muyenera Kukumbukira Pambuyo pa Kufufuza kwa SPMS
Ngati inu kapena wokondedwa wanu muli ndi SPMS, pali zinthu zingapo zomwe muyenera kukumbukira.
Choyamba, ndikofunika kudziwa kuti kusunthira gawo la SPMS kuchokera ku RRMS silolakwa chanu. Ndipotu, anthu ambiri adzasintha kupita ku SPMS pomalizira pake, ngakhale kuti chiwerengero cha kusintha kumeneku chimachitikabe. Izi zili choncho chifukwa kuyamba kwa mankhwala atsopano opatsirana matenda ndikochititsa kuti matenda a anthu ena apite patsogolo kwambiri.
Chachiwiri, ndizofunikira kuzindikira kuti monga RRMS, zizindikiro za SPMS zimasintha, monga momwe chiwerengero chakupita patsogolo, kutanthauza kuti anthu ena amakhala olumala kwambiri kuposa ena (ndipo mofulumira kuposa ena).
Chachitatu, ngati MS yanu ikupita, katswiri wanu wamagulu adzayambiranso njira zowonzetsera, kuphatikizapo mankhwala anu, kuti mukhale ndi mphamvu zogwirira ntchito ndikuthandizani kukhalabe amphamvu ndi kuyenda.
Mawu Ochokera
Mfundo yayikulu apa ndi yakuti matenda a SPMS amafunika njira zosiyanasiyana zozindikiritsira, kuphatikizapo kufufuza kwapadera kwa magazi ndi kubwereza . Mofanana ndi RRMS, palibe slam-dunk mayesero. M'malo mwake, matendawa ndi kachipatala ndipo akugwiritsidwa ntchito ndi dokotala wokhoza kuyika pamodzi mapepala anu a MS.
> Zotsatira:
> Ontaneda D, Fox RJ. Mafupa ochulukirapo ambiri. Curr Opin Neurol. 2015 Jun; 28 (3): 237-43.
> National MS Society. (nd). Kusanthula MS (SPMS) yachiwiri yopititsa patsogolo.
> National MS Society. (nd). Mafunso Omwe Amadzifunsa Kawirikawiri za SPMS.
> Schlaeger R et al. Mphepete wamtsempha mutu wa atrophy umagwirizana ndi multiple sclerosis wolumala. Ann Neurol. 2014 Oct; 76 (4): 568-80.