HMGB2 Yogwirizana ndi Kukalamba ndi Kumeta Kanyama
Chifukwa cha Kukhazikitsidwa kwa Cartilage
Kafukufuku akhala akuyesetsa kuti adziwe chomwe chimayambitsa matenda a khunyu omwe amapezeka ndi osteoarthritis . Kusintha kwa asayansi kumatanthawuza kuti kutayika kwa mapuloteni enieni kuchokera kumalo osanjikiza a karoti m'mbali. Puloteni imeneyi, yomwe imatchedwa HMGB2, ikuwoneka kuti imakhala ndi gawo lofunika kwambiri mu kutupa kwa kagaweti.
Apa pali zomwe zimachitika m'kukhazikika kwa kanyumba
Katemera wotchedwa articular cartilage ndiwopweteka koma minofu yowonongeka yomwe imayika mafupa mkati mwa mgwirizano, yomwe imalola kuyenda mofulumira.
Cartilage imapangidwa ndi kusungidwa ndi maselo a chondrocyte, ndipo imaphatikizapo collagen ya fibrous ndi ma proteoglycans.
Osteoarthritis imayamba pamene pali chisokonezo pamtunda wa kagawoti - imatchulidwanso ngati malo okhazikika. Malo osanjikizika ndi ofunikira kwambiri pa mbali zinayi za karotila mumphati, mogwirizana ndi kuyenda koyenera. Makhalidwe ovomerezeka ali ndi tinthu tomwe timapanga tizilombo tomwe timavomereza. Cartilage imathandizanso kugwirizanitsa mapulogalamu ndi kutenga mphamvu. Koma pamene chigawo choyamba chikuyamba kuwonongeka, komabe osteoarthritis imayamba kukula ndipo njira yosasinthika imayambika kuti potsirizira pake iwononge kagawo kake mpaka mapeto atha: fupa likuphwanya pfupa palimodzi.
Ochita kafukufuku azindikira kuti chiyambi cha matenda a osteoarthritis chinagwirizanitsidwa ndi kuwonongeka kwa karoti m'kati mwake. Chimene ofufuza tsopano akudziwa kuti ngakhale chisanakhale chiwonongeko chapadziko lapansi, pali kutayika kwa DNA-zomanga thupi, HMGB2.
Zambiri Zokhudza HMGB2 ndi Udindo Wake mu Cartilage Health
Pamwamba pamtundu wa cartilage m'magulu, HMGB2 imathandiza kupulumuka kwa chondrocyte. Chondrocytes ndiwo maselo okhawo omwe amapezeka mu kagaweti - amapanga khungu. Mwachidule, kutayika kwa HMGB2 kumakhudzana ndi ukalamba ndipo ndi chondrocytes zomwe zimachepetsedwa kapena zimachotsedwa pamtunda wa kanyumba.
Ngati HMGB2 ndi chondrocyte wathanzi, imapereka njira yopangira chithandizo chamankhwala kuti asunge khunyu ndikuletsa kuchepa kwake.
Zomwe Kuchita Uku Kukutanthauza Tsogolo
Kodi tanthauzo la kupeza? Zinachokera ku mgwirizano pakati pa ofufuza a Scripps Research Institute ku La Jolla, California; University of San Raffaele ku Milan, Italy; ndi Kunivesite ya Kogoshima ku Japan.
Zotsatira zamtsogolo za kafukufuku zingathe kuyenda m'njira ziwiri. Akhoza kuyang'ana mamolekyu omwe amaletsa kuwonongeka kwa HMGB2 ndikuwathandiza kukhala mankhwala osokoneza bongo. Akhoza kufunafuna njira zothandizira kupanga HMGB2, makamaka kwa anthu omwe kale ali ndi matenda a cartilage, kukonza khalala. Matenda a osteoarthritis amatha kuwomboledwa kapena kuwomboledwa tsiku lina. Kutulukira kwa udindo wa HMGB2 mu osteoarthritis kungakhudzenso momwe maselo amadzigwiritsire ntchito kugwiritsiranso ntchito minofu m'tsogolomu.
Zingatheke kuti HMGB2 ndi gawo laling'ono chabe la chithunzi cha kutupa kwa kagawoti. Kafukufuku amatulutsa chidziwitso chosangalatsa chomwe chimatha kukhala chimaliziro. Zingatheke kupeza mankhwala omwe amakhudza HMGB2 m'njira yoyenera kukonzanso ndi kumanga khalala. Koma chidziwitso chilichonse chatsopano ndi chilumikizano chatsopano chikhoza kupititsa patsogolo pakupewa ndi kuchiza osteoarthritis.
Chitsime:
Kuwonongeka kwa chromatin mapuloteni HMGB2 okhudzana ndi kukalamba kumapangidwe kanyama kakang'ono kamagwirizanitsidwa ndi kuchepetsedwa kwa maselo ndi osteoarthritis. Tanaguchi N et al. PNAS.