Dothi la Spakles ndi Mafomu ena a Valproate
Valproate ndi mankhwala omwe amatchulidwa kuti ndi mankhwala a antiticvulsant ndipo motero amaperekedwa kuti athetse vutoli. Limaperekedwanso nthawi zina kupewa mutu wa mutu wa migraine ndi kuchepetsa matenda a manic mu matenda ochititsa munthu kusinthasintha maganizo. Madokotala ena amaperekanso kuti azitsatira khalidwe lovuta mu matenda a Alzheimer ndi mitundu ina ya matenda a maganizo .
Kugwiritsira ntchito valproate mwanjirayi kumaonedwa ngati palibe chifukwa chakuti sivomerezedwa ndi US Food and Drug Administration (FDA) kuti izi zitheke.
"Zamagetsi a Valproate ndi monga valproate sodium (Depacon), divalproex sodium (Depakote, Depakote CP, ndi Depakote ER), valproic acid (Depakene ndi Stavzor), ndi ma generics awo," malinga ndi FDA.
Maonekedwe Osiyana a Valproate
Valproate amadza ndi mitundu yosiyanasiyana, kuphatikizapo mapiritsi, mapiritsi otulutsidwa, ma capsules ali ndi valproate sprinkles (ma capsules angamezedwe kwathunthu kapena kutsegulidwa ndipo zomwe zili mkati mwazidya zofewa kwa iwo omwe akuvutika kumeza) ndi jekeseni / IVs kwa iwo omwe sangathe kumwa mankhwala achipatala.
Nchifukwa chiyani Valproate Yagwiritsidwa Ntchito Pochita Zopinga Zovuta ku Dementia?
Imodzi mwa mavuto mu matenda a Alzheimer ndi kuti umunthu ndi makhalidwe angathe kusintha chifukwa cha matendawa. Zina mwazovuta zomwe zimakhalapo m'maganizo aumphawi zingakhale monga kusokonezeka , kupuma, kusagwirizana , kumenyana ndi mawu , kukana chisamaliro, kusuntha ndi kulingalira zapakati .
Zingakhale zovuta kudziwa momwe mungayankhire ndi mitundu iyi ya makhalidwe ndi maganizo.
Achipatala ayesa mankhwala osiyanasiyana kuti ayese kuchepetsa makhalidwewa, kuphatikizapo mankhwala oletsa antipsychotic (omwe angathe kukhala ndi zotsatira zoyipa kwambiri ndipo amatsogoleredwa kwambiri ndi makampani osungirako anthu okalamba), benzodiazepines (yomwe imabwera ndi zotsatira zoipa komanso zovuta). zowonongeka (zomwe sizothandiza nthaŵi zonse kapena zoyenera).
Mfundo yaikulu ndi yakuti nthawi zambiri si mankhwala othandiza kwambiri kuti athetse kusokonezeka kwa makhalidwe omwe ali ndi matenda a maganizo .
Choncho, valproate rose ndikumenyana pofuna kuyesa kusokonezeka muumtima. Kuwonjezera pa chiyembekezo chokhala mankhwala ochiritsira, valproate anali ndi mwayi wopeza mankhwala omwe poyamba anawulukira pansi pa radar malinga ndi malamulo oyamwitsa a kunyumba - omwe amadziwika kwambiri pa kuchepetsa ndi kuthetsa mankhwala oletsa antipsychotic mu dementia koma osati monga momwe amaganizira pa valproate.
Kodi valproate iyenera kuyesedwa kuti ikhale ndi zovuta zolimbana ndi dementia?
Malingana ndi kafukufuku wochuluka, yankho lake ndilo: Ayi.
Kulekeranji?
Nthawi zambiri sichitha. Ngakhale kuti pali njira zodziwika zochepa zogwira mtima, kafukufuku wa kafukufuku wambiri amatsimikizira kuti valproate sizinathandizenso kupatulapo placebo (mapiritsi ophatikizira) pochepetsa makhalidwe ovuta a maganizo.
Malingana ndi kafukufuku wina wofalitsidwa ku JAMA Psychiatry , valproate nayenso analepheretsa kuchepetsa chidziwitso cha matenda a maganizo a munthu, chiyembekezo chopindulitsa chimene sichinawonekere ndi ntchito yake.
Zotsatira Zotsatira
Kafukufuku wochuluka anapeza kuti omwe adalandira valproate anali pangozi yaikulu ya zotsatira za mankhwala.
Zotsatira zake zinaphatikizapo thrombocytopenia (mapulitsi ochepa a magazi), kuwonjezereka kwowonjezereka, kusokonezeka kwadzidzidzi, kunjenjemera, kusokonezeka ndi kugona, kusanza, kusanza, ndi kutsekula m'mimba.
Njira Zina Zochitira Valproate
M'malo mofikira botolo la mankhwala kuti asinthe makhalidwe ovuta muumphawi, njira yoyamba iyenera kukhala njira zopanda mankhwala . Ganizirani zinthu zomwe zingayambitse makhalidwe monga chilengedwe , ululu wamthupi, kusasamala kapena kupuma ndipo yesetsani kukonza ndi kusintha zomwe zingayambitse.
Gwiritsani ntchito njira monga kulola munthuyo nthawi yodziletsa yekha ndikubweranso kuti amalize ntchito yomwe mukuyesa kukwaniritsa.
Pomaliza, dziwani kuti kusamalira nkhawa ndi kupsinjika maganizo kungapangitse makhalidwe a munthu amene ali ndi matenda a maganizo. Onetsetsani nokha kuti zizindikiro za wotsogolera ziwonjezereke ndipo mugwiritse ntchito banja lanu, abwenzi komanso chuma chanu kuti akuthandizeni pa ntchito yanu yosamalira.
Mawu ochokera
Ndi zachilendo komanso zoyenera kufufuza chithandizo chomwe chimathandiza ndi makhalidwe ovuta omwe nthawi zambiri amakhala ndi chifuwa chachikulu. Mwamwayi, sitidzakhalanso ndi mankhwala otetezeka komanso ogwira mtima nthawi zonse.
Chifukwa cha ichi, onetsetsani kuti mukufuna thandizo ngati wothandizira popeza zizindikiro za khalidwe ndi maganizo a chiwerewere zimakhala zovuta kuzigwira. Thandizoli lingakuthandizeni kuti mukhale osungulumwa ndipo mulole osowa kuti athe kugawana njira zomwe zakhala zikuwathandiza.
> Zotsatira:
> ClinicalTrials.gov. Valproate ku Dementia (VALID). July 6, 2010.
> Chidziwitso cha Cochrane Chofufuza Zosinthika. 2009 Jul 8; (3). Valproate Kukonzekera kwa Kusokonezeka mu Dementia.
> Kuchokera. Depakote Formulations.
> JAMA Psychiatry. Chronic Divalprox Sodium to Attenuate Agitation and Clinical Progress of Alzheimer's Disease.
> Wodwala Waumoyo Waumphawi. 2012; 1 (11): 14. Kusasaka kwa Valproate kwa Okalamba Omwe Amakhala ndi Dementia: Kuunika kwa Kutaya ndi Kutaya Kuchepetsa.
> Utsogoleri wa US Food and Drug Administration. Information ya Valproate.
> Williams, L. Onse Anakhazikitsa Umboni Wathu: Valproate for Agitation in Dementia.
> Eya, Y. ndi Ouyang, W. (2012). Kusinthasintha kwabwino kwa chithandizo cha zizindikiro za khalidwe ndi maganizo a chiwerewere: Kusinthidwa kwatsopano. Kaohsiung Journal of Medical Sciences , 28 (4), pp.185-193.