Zotsatira zimasonyeza kuti mankhwalawa akhoza kuchepetsa matenda a Alzheimer
Sindimakonda kulemba nkhani zokhudza matenda a dementia ndi matenda a Alzheimer . Matenda a Alzheimer ndi matenda owawa. Ikupita mosalekeza. Mankhwala ovomerezeka a FDA kuti athetse matendawa monga Aricept, Nemenda, ndi Cognex amachita pang'ono kuti azichepetsanso matenda ake.
Akatswiri ambiri a maganizo amadziŵa kuti mankhwala ndi ofunika kwenikweni kwa odwala awo omwe ali ndi matenda a Alzheimer's.
Komabe, okondedwa amapempha mankhwala awa ndi chiyembekezo kuti mankhwalawa angathandize m'njira yaying'ono. Potsirizira pake, chithandizo chabwino kwambiri kwa iwo omwe ali ndi matenda a Alzheimer ndi chisamaliro chachisamaliro chomwe sichimangotengera khalidwe labwino kwa munthu yemwe ali ndi matenda koma komanso khalidwe la moyo kwa womusamalira yekha.
Ngakhale kuti ndakhala ndikusafuna kulemba nkhani za matenda a Alzheimers, ndagwirizana ndi ine ndekha kuti ndiphimbe matendawa ngati mayesero ena azachipatala amachititsa kuchepetsa chidziwitso cha anthu omwe ali ndi matendawa. Posachedwapa, zotsatira zoyambirira za mayesero okhudza biogen's aducanumab amasonyeza kuti mankhwalawa amachititsa kuti matenda a Alzheimer apitirire.
Matenda a Alzheimer ndi matenda ambiri a dementia. Ku United States, anthu pafupifupi 5 miliyoni a ku America a zaka 65 ndi kupitirira amakhala ndi matendawa. Njira ya matenda a Alzheimer ndi yocheperapo komanso yosasinthika.
Patapita nthawi, zochitika za Alzheimer's memory, kuziganizira, ndi kulingalira. Pambuyo pake, munthu amene ali ndi matenda oopsawa amasiyidwa kugwira ntchito zosavuta komanso zosavuta za moyo wa tsiku ndi tsiku.
Kufotokozera kwathu tsopano kwa matendawa a matenda a Alzheimer kumangopita ku "chiphunzitso cha amyloid ". Mwachindunji, matendawa amachokera ku chikho cha amyloid-beta (Aß) peptides m'mapangidwe a ubongo.
Kuwonjezeka kwa Aß kumayambitsa matenda a Alzheimer's disease pathogenesis. Chinthu chinanso chothandizira chimaphatikizapo mitsempha ya neurofibrillary yokhala ndi mapuloteni a tau. Kusiyanitsa pakati pa Aß kupanga ndi Aß chilolezo kumayambitsa mapangidwe awa.
Pakalipano, pali zida zosiyana siyana zomwe zakhala zikukonzekera kuti zithetse matenda a Alzheimer. Mwachindunji, aducanumab ya antibody imagwira ntchito poyambitsa fgo-receptor-mediated phagocytosis ya Aß plaques. M'mawu ena, aducanumab imayambitsa thupi la thupi lathu kuti lichepetse Aß.
M'zaka zaposachedwapa, "amyloid hypothesis" yafunsidwa mozama ndi kulembedwa ndi akatswiri ambiri monga opitirira malire. Sitikukhala ndi chidziwitso cha kachipatala, ndipo ambiri amakhulupirira kuti kusungunula kwa Aß kungakhale mbali yowonongeka ndi yosamvetsetseka yomwe imayambitsa chisokonezo. Makamaka, mwa iwo omwe ali ndi matenda a Alzheimer, Aß imayambitsa kutsogolo kwa zaka 10 mpaka 15 motero kumaphatikizapo pempho lachidziwitso chosavuta-ndi-zotsatira. Kuwonjezera apo, mitsempha ya puloteni yamapulotoni (APP) imapangitsa kuti Aß iwonongeke komanso zidutswa zina zomwe zingathandize pa matenda a Alzheimer's.
Malingana ndi zotsatira zapakatikati za mayesero a Pakati la 1b a aducanumab otchedwa PRIME, Biogen yadzipereka kuchipatala chachitatu cha mankhwala.
Nawa ena mwa zotsatira izi:
- Kuchiza ndi aducanumab kunachepetsa kuchepa kwa miyala ya amyloid kwa anthu okhala ndi matenda a Alzheimer's prodromal kapena mild.
- Kuchepetsa m'mipope kunkawonetsedwa pogwiritsa ntchito kujambula kwa PET, ndipo kuchepa kumeneku kunali kudalira- ndi kudalira nthawi.
- Pambuyo pa chaka chimodzi chachipatala, anthu omwe ali ndi matenda oyambirira a Alzheimer's anawonetsa kuchepetsa kuchepa kwa chidziwitso monga momwe anachitira ndi Mini-Mental Status Examination (MMSE) ndi Cognitive Dementia Rating.
- Kupewa ndi kuleza mtima kwa aducanumab kunali kovomerezeka. Zotsatira zina zovuta zinaphatikizapo mutu ndi ARIA (zolakwika zojambula zokhudzana ndi amyolo).
Kuti mankhwala a Alzheimers kapena mankhwala ena atsopano adzivomerezedwe ndi FDA, ayenera kudutsa mayesero achigawo atatu. Monga tafotokozera m'nkhani yatsopano yomwe ili ndi "Mayeso ofunika kwambiri a b-secretase inhibitors mu Alzheimers" kuchokera ku Nature Biotechnology , ena omwe amapanga mankhwala osokoneza bongo a Alzheimers amathamangira ku Mayesero a Phase 3. Chizoloŵezichi ndi choopsa chifukwa zotsatira zapadera zochokera ku mayeso a Phase 3 zidzatseka chitukuko cha mankhwala. Ndiponsotu, palibe amene akufuna kuikapo mankhwala "opsereza".
Chifukwa chakuti mankhwala samalephera kuwonetsa zotsatira zamakono pazitsulo zina za Gawo 3 sizikutanthauza kuti mankhwalawo sagwira ntchito. Mwachitsanzo, n'zotheka kuti mankhwala amatha kukhala othandiza pa mlingo wosiyana ndi omwe amayesedwa. Kapena, mankhwala ena amagwira ntchito bwino kwa anthu ena. M'malo modutsa Rubicon ndikuyamba kuyesedwa pa Gawo 3, ndibwino kuti muyesetse kuyesa kuyesa chiwerengero cha Phase 2 ndikukumvetsa bwino mankhwala ndi zotsatira zake. Mosiyana ndi zimenezi, Biogen yasankha kupitiliza mayesero amachilombo a Phase 3 chifukwa cha kulimbikitsa zotsatira zochokera ku mayesero a Phase 1b (apansi).
Ngati inu kapena wokondedwa wanu akudwala matenda a Alzheimers, chonde werengani nkhaniyi mkati mwazomwe muli komanso popanda chiyembekezo cholakwika. Biogene ikadali nthawi yochuluka yokonzera chiyanjano cha aducanumab, ndipo tikufunikirabe zotsatira zambiri zachipatala. Ngakhale zotsatira zoyambirira zokhudzana ndi aducanumab zikudalira, mankhwala osokoneza bongo a Alzheimers amadziwika kuti sakulephera kudula mpiru, ndipo sitidali ndi mankhwala othandiza kwambiri omwe amathandiza kuchepetsa kukula kwa matendawa.
Zosankha Zosankhidwa
Nkhani yotchedwa "The Amyloid Hypothesis ya Matenda a Alzheimers: Kupita patsogolo ndi Kulonjeza Njira Yopereka Chithandizo" mwa J Hardy ndi DJ Selkoe yofalitsidwa mu Sayansi mu 2002. Anapezeka pa 3/22/2015.
Ropper AH, Samuels MA, Klein JP. Mutu 39. Matenda opatsirana a Nervous System. Mu: Ropper AH, Samuels MA, Klein JP. eds. Adams & Victor's Principles of Neurology, 10e . New York, NY: Hill ya McGraw; 2014. Kupezeka pa March 22, 2015
Mutu wotchedwa "Mayesero Ofunika a ß-secretase inhibitors mu Alzheimer's ndi Cormac Sheridan yofalitsidwa mu Nature Biotechnology mu 2015. Opezeka pa 3/22/2015.