Kodi Nchiyani Chimachititsa Eosinophilia?

Kubwereza Zomwe Zimayambitsa, Kuzindikira, ndi Kuchiza Eosinophilia

Eosinophilia ndi dzina lachidziwitso la kuchuluka kwa chiwerengero cha eosinophil. Mankhwala a Eosinophil ndi mtundu wa maselo oyera a magazi omwe amawononga zinthu m'thupi monga tizilombo toyambitsa matenda komanso kutenga nawo mbali pamaganizo.

Kodi Nchiyani Chimachititsa Eosinophilia?

Pali zifukwa zambiri zowerengera za eosinophil zikhoza kukwera. Zina mwa zifukwazi ndi zabwino ndipo zimafuna chithandizo chamankhwala.

Si zachilendo kuti chiwerengero chokwera chikhale chosakhalitsa ndi kuthetsa popanda mankhwala. Tiyeni tione zifukwa zina tsopano.

1. Matenda a Parasite: Padziko lonse, chifukwa chachikulu cha matenda a eosinophilia ndi matenda opatsirana. Maina a matendawa ndi monga schistosomias, trichinosis, strongyloidiasis, ndi ascariasis. Mitunduyi imapezeka padziko lonse kuphatikizapo United States. Mbiri ya maulendo ndi gawo lofunika kwambiri la ntchito ya eosinophilia ngakhale kuti kusowa kwa maulendo atsopano sikuthetsa matenda a parasitic. 'Kutsegula m'mimba ndi mtundu wa matenda opatsirana koma siwowonjezereka ndi eosinophilia.
2. Zotsatira za mankhwala: Mankhwala akhoza kuyambitsa eosinophilia, nthawizina popanda zizindikiro zoonekeratu. Mankhwala omwe amagwiritsidwa ntchito kwambiri ndi eosinophilia ndiwo mankhwala opha tizilombo (penicillin, cephalosporins), aspirin, ibuprofen), ranitidine (for reflux gastroesophageal), phenytoin (anti-seizure) ndi allopurinol (ogwiritsidwa ntchito pochizira gout). Fomu yoopsa kwambiri imatchedwa mankhwala akuchitidwa ndi eosinophilia ndi zizindikiro zomveka (DRESS). Mwamwayi, anthu ambiri sadzakhala ndi zotsatirazi pamene alandira mankhwalawa.

1. Mankhwala : Mankhwalawa amachititsa kuti thupi likhale lopangidwa. Kawirikawiri, atopy imatchula mphumu, zozizira zakanthawi (zomwe zimatchedwanso nthenda yotchedwa rhinitis), ndi eczema. Si zachilendo kuti munthu akhale ndi zovuta zambiri kuposa izi. Izi ndi zina mwazimene zimayambitsa matenda a eosinophilia, makamaka kwa ana. Mofananamo, kupweteka kwa zakudya kungayambitsenso kuchuluka kwa chiwerengero cha eosinophil.

1. Eosinophilia esophagitis (EoE): Ichi ndi matenda omwe amadziwika ndi mapepala a eosinophils omwe amafalitsidwa ndi mitsempha yomwe imakhalabe ndi eosinophils. Pafupifupi 50% a anthu omwe ali ndi EoE adzakhalanso okweza ma eosinophil m'magazi.
2. Sypromos Hypereosinophilic : Hyperoeosinophilic syndromes (HES) ndi magulu a mavuto omwe amadziwika ndi mawerengero apamwamba kwambiri a eosinophil ndi umboni wa kuwonongeka kwa thupi kuchokera ku chiwerengero chachikulu cha eosinophils. Mankhwala omwe amapezeka makamaka ndi khungu, mapapo, ndi m'mimba. HES angakhale yoyamba (yotchedwanso neoplastic) yachiwiri (yogwira ntchito) kapena idiopathic (chifukwa chosadziwika).
3. Churg-Strauss Syndrome: Vasculitis ya Churg-Stauss, yomwe tsopano imatchedwa eosinophilic granulomatosis ndi polyangiitis, ikhoza kuyambitsa eosiniophilia. Anthu omwe ali ndi matendawa ali ndi matenda a mphumu ndi mapupa poyamba, kenaka amapanga eosinophilia, ndipo potsiriza vasculitis , kutupa kwa mitsempha ya mitsempha.
4. Khansa: Pali khansa zingapo, makamaka khansa ya magazi, yomwe imadziwika poonjezera chiwerengero cha eosinophil. Izi zimaphatikizapo mitundu yosavuta ya myeloid leukemia (AML) yotchedwa eosinophilic leukemia. Zina mwazi zimaphatikizapo zingapo za myeloproliferative (monga, thrombocythemia yofunikira, polycythemia vera) B-cell ndi T-cell lymphoma, komanso adenocarcinomas a m'mimba, mapapo, ndi chiberekero.

Kodi Ndi Zizindikiro Ziti za Eosinophilia?

Ngati muli ndi eosinophilia, zizindikiro zanu zidzatsimikiziridwa pang'ono ndi chifukwa cha kuchuluka kwa chiwerengero cha eosinophilia. Ngati chiwerengero chanu cha eosinophil chikukwera mofatsa simungakhale ndi zizindikiro zilizonse. Zizindikiro zofala zimaphatikizapo:

• Rash
• Kuyabwa
• Kutsekula m'mimba, pa matenda a tizilombo toyambitsa matenda
• Phumu
• Mphuno yothamanga, makamaka ngati ikugwirizana ndi chifuwa chachikulu.

Kodi Eosinophilia Amadziwika Bwanji?

Monga matenda ambiri a magazi, eosinophilia imadziwika pa chiwerengero cha magazi (CBC) . Eosinophils ndi imodzi mwa maselo oyera a m'magazi ndipo imapezeka mu gawo la CBC lotchedwa kusiyana. Kusiyanitsa kumabwereza kuti mitundu yambiri ya maselo oyera a magazi (neutrophil, lymphocyte, monocyte, eosinophil, ndi basophil ) imapezeka m'magazi.

Pambuyo pozindikiritsa za eosinophilia, wothandizira zaumoyo wanu ayamba kugwira ntchito pofuna kuzindikira chomwe chimayambitsa, nthawi zina izi zimafuna kutumiza kwa munthu wodwala matenda a shuga. Kulemera kwa eosinophilia nthawi zina kumatha kuyendetsa ntchito yofunikira. Eosinophilia ikhoza kugawidwa ndi chiwerengero cha eosinophils (mtheradi wa eosinophil count).

• Wofatsa: 500 - 1500 maselo / mL
• Okhazikika: 1500 - 5000 maselo / mL
• Zovuta:> 5000 maselo / mL

Kudziwa chomwe chimayambitsa eosinophilia chidzakhazikitsidwa pa zizindikiro zanu. Matenda a Eosinophilia angayambitse kumeza, chifuwa ndi / kapena kupweteka kwa m'mimba, kusanza kapena chakudya kukakamira m'mimba. Kusanthula kumafuna biopsy ya phokoso. Matenda ambiri a tizilombo toyambitsa matenda amapezeka ndikutenga zitsulo ndikuyesa. Pakhoza kukhalabe mayeso kuti mudziwe ngati mankhwala ndi omwe amachititsa kuti mukhale ndi eosinophilia. Ngati nambala yanu ya eosinophil imabwereranso kuthupi pambuyo posiya kumwa mankhwala, nthawi zambiri amaganiza kuti mankhwalawa ndiwo chifukwa.

Kodi Ndizochita Zotani Zopangira Eosinophilia?

Mofananamo ndi zomwe zimayesedwa, mankhwala amatsimikiziridwa ndi chifukwa cha eosinophilia. Zosankha zikuphatikizapo:

• Kuwonetsetsa: Ngati eosinophilia yanu ndi yofatsa, kuyang'anitsitsa ndi kubwereza mabala kungakhale kolimbikitsidwa.
• Ngati mankhwala akuyambitsa chiwerengero chanu chokwanira cha eosinophil, icho chikhoza kuthetsedwa
• Kukulitsa chithandizo cha mphumu, chizungu, ndi kudwala
• Matenda a parasite amachiritsidwa ndi mankhwala odana ndi parasitic.
• Steroids monga prednisone ingagwiritsidwe ntchito pochiza matenda osokoneza bongo

Mawu Ochokera

Hypereosinophilia ndi mawu owopsa. Mwamwayi, kwa anthu ambiri omwe ali ndi vutoli, ndizomwe zimakhala zochepa ndipo zimafuna mankhwala pang'ono. Kwa ena, matenda ndi matenda amatha kutumizidwa kwa katswiri. Ngati muli ndi zodandaula zina, onetsetsani kuti mukambirane ndi dokotala wanu.

> Chitsime:

> Weller PF ndi Klion AD. Kufikira kwa wodwalayo ndi zosawerengeka za eosinophilia. Mu: UpToDate, Post TW (Ed), UpToDate, Waltham, MA.