Nthenda ya mphumu komanso kuthamanga kwa magazi (zomwe zimatchedwa kuti "hypertension") zimakhala zosiyana kwambiri ndi thanzi labwino, choncho sizosadabwitsa ngati inu (kapena wokondedwa) muli ndi nkhawa kuti mankhwala anu a mphumu akukhudzani ndi magazi anu.
Mwamwayi, yankho silili lodulidwa komanso louma momwe mungakonde. Mwa kuyankhula kwina, ndi zovuta kwambiri kuposa inde inde kapena ayi.
Tiyeni tiwone bwinobwino momwe zimayendera mankhwala opatsirana ndi mphumu, ndi momwe izi zingakhudzire kuthamanga kwa magazi.
Mitsempha Yowonjezera Inhalers mu Asthma: Mmene Amagwirira Ntchito
Mankhwala osokoneza bongo (MDIs) ndi mankhwala omwe amadziwika bwino komanso omwe amalembedwa. Ndipotu, ngati muli ndi mphumu, mwayiwu ndi pafupifupi 100 peresenti kuti ma ARV ndi mbali yodziwika bwino ya chithandizo chanu. Ichi ndi chifukwa chakuti ma ARV ali ofulumira kuchita komanso oti agwiritsidwe ntchito ngati mpumulo wa nthawi yayitali kuchokera ku zovuta za chifuwa ndi kupuma kovuta kukumana ndi masoka a mphumu mwadzidzidzi.
Mankhwala omwe ali ndi MDIs amagwira ntchito pogwiritsa ntchito makompyuta, otchedwa beta receptors, omwe amamanga malinga a mapewa. Ngati mankhwalawa athandizidwa, mapulogalamuwa amachititsa kuti mapepala apumphukire akule, kuthetsa zizindikiro za mphumu. Chifukwa cha momwe zimagwirira ntchito, mankhwalawa amatchedwa beta-agonist (amachititsa ntchito ya beta receptors).
Ovomerezeka a Beta ndi olamulira ofunika kwambiri a mitsempha ya magazi, kumene ntchito yawo imathandiza kuchepetsa mitsempha ya magazi.
Ndipotu, mwinamwake mwamvapo za beta blockers, mtundu wambiri wokhuza magazi . Ogwira ntchito ya Beta amagwira ntchito poletsa kutsegula kwa magazi a zotengera za beta. Izi zikutanthauza kuti zotengerazo zimakhala zowonjezereka (kapena zowonjezereka) kuposa zachizolowezi, zomwe zimachepetsa kuthamanga kwa magazi.
Mankhwala a mphumu: Zotsatira za Kupsinjika kwa Magazi
Ndizomveka kudabwa ndi zotsatira za mankhwala a asthma omwe angakhale nawo pa kuthamanga kwa magazi chifukwa cha ntchito yawo ya beta-agonist.
Mwakulankhula kwina, ngati mankhwala a mphumu amachititsa kuti ntchito ya beta iwonjezeke, ndipo kuwonjezeka kwa ntchito ya beta kumayambitsa kuwonjezereka kwa magazi, ndibwino kuganiza kuti mankhwala a mphumu amachulukitsa kupsyinjika kwa magazi.
Koma choonadi chiri pakati penipeni. Ngati mukanawulula mitsempha ya magazi kwa mankhwala a beta-agonist asthma, mungathe kuona zochepa za chotengera chotengera. Komabe, izi sizichitika kawirikawiri kwa odwala a mphumu pogwiritsa ntchito MDIs, ndipo pali zifukwa zambiri izi:
- Mankhwala opatsirana pogonana ndi mankhwala osokoneza bongo, ndipo pafupifupi 100 peresenti ya mankhwala imakhalabe m'mapapo, komanso kutali ndi mabotolo a beta pamitsinje ya magazi.
- The beta agonist yomwe imagwiritsidwa ntchito mu MDIs (albuterol) imasankha (ngakhale osati mwangwiro) kwa kachigawo kakang'ono kamene kamene kamapezeka m'matumbo, koma m'magawo ang'onoang'ono a mitsempha ya magazi.
- Albuterol ili ndi nthawi yochepa kwambiri ya ntchito, choncho ngakhale mankhwala ochepa angapeze njira yopita ku mitsempha ya magazi, ndipo kachilombo kakang'ono kameneka kangayambitse zotengerazo, zotsatira zake zimapita mofulumira.
Pogwiritsa ntchito mankhwala osokoneza bongo, albuterol, ena a agonist, omwe amakhala ndi moyo wautali, amagwiritsidwa ntchito pochiza mphumu.
Izi zimaphatikizapo mankhwala monga fenoterol (nyengo yapakati, yosagwiritsidwa ntchito ku US) ndi Severent (salmeterol), yomwe ili ndi moyo wautali.
Ngakhale mankhwalawa akupitirirabe m'thupi kwa nthawi yaitali kuposa albuterol, iwo amachiritsidwa, amakhalabe m'mapapo, ndipo samakonda kugwira bwino ntchito ya mtundu wa beta omwe amapezeka pamitsuko ya magazi.
Mawu Ochokera
Mfundo yayikulu apa ndi yakuti pamene mankhwala anu a mphumu akhoza kutulutsa mwazidzidzidzi kuthamanga kwa magazi chifukwa cha ntchito ya beta-agonist, izi sizinthu zomwe muyenera kudandaula nazo.
Ngakhale zili choncho, ndizofunika kwambiri kupanga dongosolo la kasamalidwe ka asthma ndi pulmonologist wanu, wotsutsa, kapena dokotala wamkulu wa chisamaliro.
Ndondomeko yanu ikhale ndi mfundo zitatu izi:
- Momwe mungapewere bwino popeweratu oyambitsa mphumu wapadera.
- Mndandanda wa mankhwala omwe muyenera kutenga kuti mupewe zizindikiro za mphumu (mankhwala opangidwa ndi corticosteroid) omwe mumagwiritsa ntchito kuti muwathandize kuthetsa vuto la mphumu (albuterol inhaler).
- Ndondomeko ya ndondomeko kukuthandizani kudziwa nthawi yomwe mukufuna kupita kuchipatala.
Pamapeto pake, chonde auzeni dokotala mankhwala onse omwe mukuwatenga, monga ena angagwiritsire ntchito mankhwala anu a mphumu monga aspirin , antisteroidal anti-inflammatories, kapena beta-blockers .
Zotsatira:
American Academy of Allergy Chifuwa & Immunology. (2017). Mankhwala ndi Okalamba Achikulire.
> Arboe B, > Ulri > CS. Beta-blockers: mnzanu kapena mdani mu asthma? Int J Gen Med . 2013; 6: 549-55.
> Mankhwala Osokoneza Bongo Akukhudza Njira Yopuma. Mu: Pharmacology, 2nd Ed, Mycek, MJ, Harvey, RA, Champe, PC (Eds), Lippincott, Williams, ndi Wilkins, Philadelphia, PA 2000. p.217-222.