Kugwirizana Pakati pa Aspirin ndi Phumu
Anthu ambiri saganizira mozama za kutha kwa aspirin pamene ali ndi kupweteka mutu. Koma kwa anthu ena omwe ali ndi mphumu , mankhwala osavutawa akhoza kupha.
Kodi Aspirin-Indedi Amadzimadzi?
Aspirin ndi mankhwala ena osakanikirana ndi mankhwala osokoneza bongo (NSAIDS) monga ibuprofen , naproxen, ndi diclofenac zapezeka kuti zimayambitsa matenda a mphumu kwa anthu omwe ali ndi mphumu.
Matenda a mphumu omwe amachititsa aspirin ndi NSAIDS nthawi zambiri amakhala oopsa ndipo akhoza kuopseza moyo. Matenda a aspirin amawoneka ngati akukula pamene anthu akula, ndipo ndi zovuta kwambiri kwa anthu omwe ali ndi mphumu yovuta kwambiri.
Matendawa adziwika kwa zaka zambiri, koma sanadziwe kuti ndi anthu angati omwe ali ndi mphumu omwe adakumana ndi chiopsezo pamene akugwiritsa ntchito mankhwala omwe amagwiritsidwa ntchito mpaka maphunzirowo atapangidwa.
Phunziro lalikulu la 2004 linaganizira za maphunziro opangidwa ndi aspirin-induced asthma (AIA kwaifupi). Ofufuzawa adadabwa kuona kuti ana asanu pa ana asanu aliwonse omwe ali ndi mphumu ndi 21 peresenti ya anthu akuluakulu omwe ali ndi mphumu adayamba kudwala AIA.
Zotsatira za phunziroli ndizofunikira chifukwa anthu omwe akukhudzidwawo anali "otsutsidwa" ndi aspirin mozungulira, zomwe zinapangitsa kulingalira molondola kwa momwe anthu angakhudzidwe ndi AIA. Njirayi yoperekera phunziroli inachepetsera mwayi woti anthu angayambe kugwidwa ndi matenda a mphumu ku matenda omwe amachititsa aspirin, zomwe akatswiriwa anazichita mobwerezabwereza.
Ndipotu, ofufuzawo anapeza kuti anthu akafunsidwa kuti afotokoze masewera olimbitsa thupi a aspirin asanakhalepo, mlingo wa mayankho abwino anali 2,7 peresenti yokha.
Chifukwa chiyani Aspirin Nthawizina Amayambitsa Nthenda ya Asulu?
Madokotala ndi ochita kafukufuku poyamba ankakhulupirira kuti chodabwitsa chimenechi sichinayanjane ndi aspirin.
Komabe, tsopano akukhulupirira kuti aspirin imayambitsa chifuwa cha mphumu mwa anthu ena chifukwa aspirin imakhala ngati wolamulira wa leukotrienes. Leukotrienes ndi zinthu m'thupi zomwe zimachititsa kutupa komanso zizindikiro zambiri za mphumu.
Kodi Pali Aspirin Mamembala Amene Ali Otetezedwa kwa Anthu AIA?
Anthu omwe ali ndi AIA ali pachiopsezo chotengera mphuno kwa NSAIDS, omwe ndi madokotala omwe nthawi zambiri amapereka kwa anthu omwe sagwirizana ndi aspirin. Kafukufuku apeza kuti pafupifupi anthu onse - omwe ali ndi AIA amakhalanso ndi maganizo oipa kwa NSAIDS. Zikuoneka kuti kuvutika ndi matenda a mphumu kunali kwakukulu mwa anthu omwe anachita ndi aspirin ngakhale pang'ono.
Odwala omwe ali ndi AIA anayesedwanso kuti awone momwe angayankhire ndi acetaminophen (Tylenol), wotsatira wa aspirin wamba. Ndi mankhwalawa, anthu 7 peresenti yokha omwe ali ndi AIA anali ndi mphumu ya asthmatic. Apanso, anthu omwe ankakonda kwambiri aspirin amatha kuchitapo kanthu ndi acetaminophen.
Gulu lina la mankhwala opatsirana opweteka, anti-inflammatory cyclooxygenase-2 (COX-2) inhibitors monga celecoxib (Celebrex), agwiritse ntchito njira yowonjezera yotupa kuposa aspirin ndi NSAIDS. Chifukwa mankhwalawa ali ndi chingwe chochepa kwambiri pa njira yotupa, samawoneka kuti ali ndi zotsatira zofanana kwa anthu omwe ali ndi mphumu.
Ngakhale kuti COX-2 inhibitors siili ndi zotsatira zovuta zowononga mphumu monga aspirin ndi NSAIDS, mankhwala a COX-2 omwe amaletsa chiopsezo amatha kuonjezera chiopsezo cha mtima ndi matenda opha ziwalo. Anthu omwe ali ndi AIA ndipo omwe amafunikira mankhwala oletsa-kutupa ayenera kulankhula ndi adokotala za kuopsa ndi phindu la celecoxib.
Kuchiza ndi Kuteteza Aspirin-Kuchepa Kumafupa
Anthu omwe ali ndi AIA amayamba kukhala ndi zizindikiro mkati mwa mphindi 30 mpaka 2 ochepa atatenga aspirin kapena NSAIDS, ndipo vuto lopuma limatha maola ambiri. Mankhwalawa ndi ofanana ndi omwe ali ndi vuto lalikulu la kupwetekedwa kwa mphumu - kupulumutsidwa mwamsanga-mpweya, ndi oxygen ndi steroids chifukwa cha zizindikiro zoopsa.
Mankhwala a leukotriene ndi mtundu wina wa mankhwala a mphumu omwe amatha kusintha zizindikiro kwa odwala aspirin. Chifukwa mankhwalawa amaletsa ma leukotrienes, omwe asonyezedwa kuti amagwira ntchito yaikulu ku AIA, mankhwalawa, pamodzi ndi steroid yosakanizidwa, amalembedwa kwa anthu omwe ali ndi AIA.
Njira yabwino yopewera mankhwala omwe amachititsa kuti asokonezeke ndi kupewa aspirin ndi NSAIDS. Anthu omwe ali ndi mphumu komanso sadziwa ngati adayankhapo aspirin m'mbuyomu ayenera kufunsa dokotala ngati ali otetezeka kuti ayesetse kukhala ndi mphamvu ya aspirin ndi NSAIDS. Izi ziyenera kuchitidwa pokhazikika chifukwa cha chiopsezo chachikulu chochita.
Anthu omwe amadziwika ndi aspirin / NSAID kukhudzidwa omwe amafunikira aspirin kapena mankhwala odana ndi kutupa kuti athe kuchiza matenda ena, monga matenda a mtima kapena matenda a rheumatic, akulimbikitsidwa kuti azitsatira aspirin. Izi zikhoza kuchitidwa ndi dokotala yemwe amadziwika bwino pa chifuwa chachikulu ndi matenda aumunthu. Izi zikachitika, ndizofunika kuti munthuyo apitirize kutenga aspirin tsiku ndi tsiku, choncho adzalandira chilakolako.
Zotsatira:
Gyllfors, P., et al. Zizindikiro za sayansi ndi zachipatala zosonyeza kuti aspirin-zosagwirizana ndi matenda a asthmatic akulepheretsa cyclooxygenase 2-yosankha mankhwala ochepetsa mankhwala osokoneza bongo. J Zachilombo Zamtundu wa Immunol . 2003 May; 111 (5): 1116-21.
Jenkins, C., Costello, J., & Hodge L. Kuwonetsetsa kwapadera kwa aspirin kunayambitsa mphumu komanso zomwe zimawathandiza kuti azitha kuchita. " BMJ 2004 Feb 21; 328 (7437): 434.
Macy, E., ndi al. Matenda a Aspirin ndi kutaya mtima kwa aspirin-kuwonjezereka matenda opuma: Mchitidwe. Ann Zozizira Nthenda Immunol. 2007 Feb; 98 (2): 172-4.
National Heart Lung ndi Magazi Institute. Dipatimenti ya Zaumoyo ya Umoyo ku United States, National Institutes of Health. (August 2007). Lipoti la Panja la akatswiri 3: Malangizo Othandiza Kuzindikira ndi Kusamalira Kachifuwa: Full Report 2007 .