Kufunika kwa Mayesero a Zamalonda Kumasintha ndi Kuyika ndi Anthu
Chiŵerengero cha CD4 / CD8 ndi kuyeza kwa machitidwe a chitetezo cha munthu, poyerekeza ndi kuchuluka kwa "CD" T-cell kwa "suppressor" CD8 T-cells. Kuyeza koyambirira ndi njira imodzi yothetsera matenda, monga pamene munthu ali ndi HIV .
Kumvetsetsa Mmene CD4 ndi CD8 T-Cell zimayendera
CD4 ndi CD8 zimangokhala mitundu iwiri yosiyana ya glycoprotein yomwe imapezeka pamwamba pa T-maselo ndi ma lymphocytes ena (gulu la maselo oyera a m'magazi akuluakulu ku chitetezo cha mthupi).
CD4 T-maselo amaonedwa ngati "othandizira" chifukwa ndi omwe amachititsa kuti chitetezo cha mthupi chitetezeke ngati akudwala tizilombo toyambitsa matenda.
Izi zikachitika, maselo a TT8 a CD8 "suppressor" amachitidwa kuti amenyane ndi kupha tizilombo toyambitsa matenda. Iwo amachitapo kanthu mwa kutseka ntchito ya CD4 pamene pamapeto pake pali chitetezo chokwanira choteteza thupi.
Chiŵerengero cha CD4 / CD8 chimaonedwa kukhala chachilendo pakakhala pakati pa 1.0 ndi 4.0. Munthu wathanzi yemwe amamasulira pakati pa 30-60% CD4 T-maselo ndi 10-30% CD8 T-maselo.
Komabe, pamene munthu ali ndi kachilombo ka HIV , kawirikawiri amachepetsa 30% pa chiwerengero cha CD4 T-maselo monga HIV imawombera maselowo ndikuwonetsa manambala awo. Mosiyana ndi zimenezi, CD8 T-maselo idzawonjezeka ndi pafupifupi 40 peresenti panthawiyi, ngakhale kuti angathe kuthetsa kachilombo ka HIV pakapita nthawi chifukwa pali ma CD4 T-maselo ochepa omwe angayankhe bwino.
Pamene mankhwala opatsirana pogwiritsa ntchito ma ARV amayamba panthaŵi yake kwa munthu yemwe ali ndi kachilombo ka HIV, chiŵerengerochi chimabwereranso kuchibadwa.
Komabe, ngati mankhwala akuchedwa, thupi limatha kubwezeretsa CD4 T-cells, ndipo chiŵerengerocho chimakhala pansi pa 1.0.
Chomwe CD4 / CD8 Chiwerengero Chikutiuza
Mtengo wa prognostic wa CD4 / CD8 umaonedwa kuti suli wofunikira kwambiri kwa oyang'anira kachirombo ka HIV kuposa zaka 20 zapitazo, pamene mankhwala ochepetsa kachilombo ka HIV amatha kuchepetsa, komanso osagwira ntchito.
Ngakhale kuti zikhoza kuwonetsa zaka za matenda ndi kufala kwa kufala kwa Edzi , kulimbikitsidwa kwakukulu lero kumayambitsanso kupatsirana kwa kachilombo koyambitsa matenda a HIV (pofuna kufooketsa matenda) ndikupewa kupititsa patsogolo kachilombo ka HIV kukana .
Pomwe zikunenedwa, kuwonjezeka kwapadera kumaikidwa pa CD4 / CD8 zokhudzana ndi ukalamba wa HIV . Kafukufuku wam'chipatala posachedwa waganiza kuti odwala pa ART, omwe amakhala ndi nthawi yaitali, omwe ali ndi kachilombo ka CD4 / CD8, amakhala ndi chiopsezo chowonjezereka cha matenda osokoneza bongo omwe alibe HIV.
Pali mbali zina zomwe CD4 / CD8 chiwerengero chingakhale choyenera. Mu kufufuza kwa matenda a matenda, angagwiritsidwe ntchito ngati phindu loyesa kuchuluka kwa matendawa (mwachitsanzo, kuthekera kwa tizilombo toyambitsa matenda) kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo ta HIV.
Zitha kugwiritsidwa ntchito kufotokoza kuti chithandizo cha IRIS (matenda opatsirana pogwiritsa ntchito chitetezo cha chitetezo cha m'madzi) chimatha nthawi zina pamene munthu ayambitsa mankhwala opatsirana pogonana. Ngati chiwerengero cha CD4 choyambirira ndi chochepa ndipo chikugwirizana ndi chiwerengero chochepa cha CD4 / CD8 chiri pansi pa 0.20, mwayi wa IRIS chochitika chikuwonjezeka kwambiri.
Mofananamo, kafukufuku wasonyeza kuti chiwerengero chochepa cha CD4 / CD8 m'mabanja obadwa ndi amayi omwe ali ndi kachilombo ka HIV ndikulingalira kuti mwanayo adzakhala seroconvert (kutsimikiziridwa kuti ali ndi kachilombo ka HIV) , ndipo mwinamwake kuwonjezeka kwakukulu pamene chiwerengero chiri pansi pa 1.0.
Izi zingakhale zofunikira makamaka m'mayiko omwe akutukuka kumene chiwerengero cha kuwonetsa kwa amayi ndi mwana kwachepa kwambiri koma chiwerengero cha ana omwe ali ndi kachilombo ka HIV pamakhalabe pamwamba.
Zotsatira:
Mahnke, Y .; Greenwald, J .; DerSimonian, R .; et al. "Kuwonjezeka kosankhidwa kwa ma CD4 okhudza tizilombo toyambitsa matenda omwe ali ndi kachilombo ka HIV-1 omwe ali ndi kachilombo koyambitsa matenda opatsirana pogonana." Magazi. March 29, 2012; 119 (13): 3105-3112.
Zijenah, L .; Katzenstein, D .; Nathoo, K .; et al. "T tymphocytes T omwe ali ndi kachilombo ka HIV ndi osaphatikizidwa: chiŵerengero cha CD4 / CD8 monga chothandizira kuti apeze kachilombo koyambitsa matenda kwa ana osapitirira zaka ziwiri . " Journal of Translational Medicine. 1 February 2005; 3: 6: yesani: 10.1186 / 1479-5876-3-6.
Seng, R .; Goujard, C .; Krastinova, E ;; et al. "Kukhudzidwa kwa moyo wathanzi wokhudzana ndi kachilombo koyambitsa matenda a HIV pafupipafupi kuwonetsa CD4 + kuchuluka kwa CD4 + / CD8 + pakati pa odwala omwe amaphatikizapo mankhwala opatsirana pogonana." AIDS . January 13, 2015; inasindikizidwa patsogolo pa kusindikiza; DOI: 10.1097 / QAD.0000000000000571.