Kukonzekera kwa Mabakiteriya M'mapungulo Ndi Cystic Fibrosis
Mwinamwake mwamvapo za bakiteriya kolonisation ngati mukukhala ndi cystic fibrosis. Kodi izi zikutanthauza chiyani?
Kodi Chikoloni ndi chiyani?
Makoloni amapezeka pamene tizilombo toyambitsa matenda timakhalapo kapena tizilombo toyambitsa matenda koma sitimenya tizirombo kapena kuwononga. Ukoloni umatanthawuza kupezeka kwa tizilombo toyambitsa matenda zomwe zingayambitse matenda, koma osati ku matenda omwewo.
Komabe, kukhala ndi tizilombo toyambitsa matendawa, kumawonjezera chiopsezo chotenga kachilomboka ngati malo oyenera a kachilomboka amapezeka.
Kufunika kwa Akoloni mu Cystic Fibrosis
Anthu omwe ali ndi cystic fibrosis (CF) nthawi zambiri amakhala ndi mabakiteriya, makamaka mu mucus ndi airways. Ngati zamoyo zimayamba kuwononga ziwalo ndi kuwononga kapena kumupangitsa munthuyo kudwala, chiwonongeko chimakhala matenda.
Kusintha kwa Zipatala Zopuma Opaleshoni Anthu Omwe Amakhala ndi Cystic Fibrosis
Kwa anthu omwe ali ndi cystic fibrosis, matenda osokoneza bongo kwambiri komanso matenda akuluakulu a bakiteriya amachititsa matenda oopsa omwe amachititsa kuti munthu asatenge matendawa. Anthu omwe ali ndi cystic fibrosis pamapeto pake amapanga bronchiectasis momwe mpweya umakhala wovulazidwa kwambiri.
Bronchiectasis ndi mkhalidwe umene bronchi ndi bronchioles (nthambi zing'onozing'ono za airways) zimakhala zowonjezereka, zowonjezereka ndi zofiira. Mucus amapezekanso m'misewu yowonjezereka yomwe imayambitsa matenda.
Matendawa amachititsa kuti kuwonjezereka, kukulitsa, ndi kupweteka kwa mpweya kubwereza chiwawa.
Pambuyo pa bronchi ndi bronchioles pali alveoli , timagulu ting'onoting'ono ta mpweya umene timapanga mpweya ndi carbon dioxide. Pamene ma bronchioles omwe amatsogolera kuzing'ono zing'onozing'ono zowonongeka amatha kutuluka (kuchokera ku thickening ndi scarring) ndipo amakhala odulidwa ndi ntchentche, mpweya wotsekedwa m'mapapu sungathe kufika pa alveoli kuti mpweya uwu uchitike.
N'chifukwa Chiyani Mipingo Ili M'gulu la Anthu Amene Ali ndi Matenda a Cystic Fibrosis Amabala Mucus Wochuluka?
Sizodziwika bwino ngati anthu omwe ali ndi cystic fibrosis poyamba amapanga ntchentche yambiri kapena amachita chifukwa cha bakiteriya. Komabe, kufufuza m'mapapo mwa ana omwe amabadwa ndi cystic fibrosis omwe sanakonzedwe ndi mabakiteriya akuwonetsa kuchulukitsidwa kwa kamasi. Zofukufukuzi zikusonyeza kuti ntchentche imagwiritsira ntchito anthu omwe ali ndi cystic fibrosis kupita ku colonia ndi mabakiteriya.
Mabakiteriya a Mtundu Wotani Amamanga Mapiko a Anthu Amene Ali ndi Cystic Fibrosis?
Mitundu yambiri ya mabakiteriya aerobic (mabakiteriya omwe amakula pamaso a oksijeni), mabakiteriya a anaerobic (mabakiteriya omwe amakula popanda oxygen) ndi tizilombo toyambitsa matenda monga bowa amachititsa mapapu a anthu omwe ali ndi cystic fibrosis. Zomwe zimatulutsa matendawa zimagwiritsidwa ntchito polongosola tizilombo toyambitsa matenda zomwe sizimayambitsa matenda opatsirana mwa anthu abwino koma zimayambitsa matenda pamene "mwayi" umapezeka, monga matenda a mapapo.
Nazi zamoyo zina zomwe zimachititsa mapapu a anthu okhala ndi cystic fibrosis:
- Pseudomonas aeruginosa
- Staphylococcus aureus (kuphatikizapo MRSA )
- Escherichia coli
- Haemophilus influenzae
- Klebsiella
- Prevotella
- Propionibacterium
- Veillonella
- Aspergillus (phunzirani za bronchopulmonary aspergillosis mwa anthu omwe ali ndi cystic fibrosis)
Mitundu Yambiri Yambiri ya Tizilomboti Tizilomboti Tomwe Timapanga Airways Kwa Anthu omwe ali ndi CF
Pa zamoyo zapamwambazi, chikomyunizimu ndi Pseudomonas chimakhala chachikulu ndipo pafupifupi 80 peresenti ya anthu akuluakulu omwe ali ndi cystic fibrosis amatha kukhala ndi mabakiteriya amtundu uwu.
Multidrug-Resistant Organisms ndi Cystic Fibrosis
Kuwonjezera pa tizilombo toyambitsa matendawa, anthu omwe ali ndi cystic fibrosis amatha kukhala ndi "superbugs" kapena zamoyo zosagwiritsidwa ntchito ndi mankhwala osiyanasiyana . Mitundu yambiri yosagwiritsira ntchito mankhwala osagwiritsa ntchito mankhwala (zamoyo zosagwirizana ndi ma antibayotiki ambiri) zimagwira m'mapapu a munthu amene ali ndi cystic fibrosis amalandira mankhwala opatsirana pogwiritsa ntchito matenda a mapapo, monga Pseudomonas.
Makoloni ndi matenda opatsirana ndi mankhwala osokoneza bongo amachititsa mantha chifukwa zamoyozi zimakana mankhwala ndi mankhwala ochiritsira ochiritsira.
Nchifukwa Chiyani Uchikoloni Ndi Pseudomonas Amalemba?
Akatswiri ali ndi malingaliro ochuluka kapena amalingalira chifukwa chake mapapo a anthu omwe ali ndi cystic fibrosis amadziwika kwambiri ndi Pseudomonas, kuphatikizapo zotsatirazi:
- Kuchepetsa chisamaliro cha umoyo ndi ubwino wa antibacterial peptides
- Kulephera kuteteza mapapo chifukwa cha kutsika kwa glutathione ndi nitrous oxide
- Kuchetsedwa kwazing'ono za mabakiteriya ndi maselo amapapu
- Kuchuluka kwa mabakiteriya othandizira
Sitikudziwa ndondomeko yeniyeni yomwe ili yofunika kwambiri pakukhazikitsa ulamuliro wa Pseudomonas. Komabe, zikuonekeratu kuti Pseudomonas akakhalapo, matenda aakulu amatha.
Anthu omwe ali ndi cystic fibrosis omwe ali ndi coloni ndi Pseudomonas amafunika mankhwala opatsirana tsiku ndi tsiku komanso mankhwala omwe amachititsa kuti matendawa asokonezeke. Mwamwayi, ngakhale matendawa, matenda a Pseudomonas amachititsa kuti mapaipi apite patsogolo ndipo amachititsa kuti anthu ambiri asaphedwe. ndi cystic fibrosis. Phunzirani zambiri za Pseudomonas mwa anthu omwe ali ndi cystic fibrosis .)
Zotsatira
Boutin, S., ndi A. Dalpke. Kupeza ndi Kusintha kwa Airway Microbiotia M'nthaŵi Yoyambirira ya Odwala a Cystic Fibrosis. Matenda a Maselo ndi Ma Cellular . 2017. 4 (1): 1.
Huang, Y., ndi J. LiPuma. The microbiome ku Cystic Fibrosis. Chipatala cha Chifuwa chachipatala . 2016. 37 (1): 59-67.
Voynow JA, Mascarenhas M, Kelly A, Scanlin TF. Cystic Fibrosis. Mu: Grippi MA, Elias JA, Fishman JA, Kotloff RM, Pakiti AI, Senior RM, Siegel MD. eds. Matenda ndi Matenda a Fishman's, Gulu lachisanu . New York, NY: Hill ya McGraw; 2015.