Pseudomonas Aeruginosa Ndizofunika Kwambiri Kwa Anthu Omwe Ali ndi CF
Pafupifupi 60 peresenti ya anthu omwe ali ndi cystic fibrosis ali ndi matenda aakulu odwala kupuma chifukwa cha mabakiteriya otchedwa Pseudomonas aeruginosa. Mabakiteriyawa amalowa m'matumbo akuluakulu atagwidwa pamtunda. Pseudomonas aeruginosa akamalowa m'kati mwa kupuma, n'zovuta kuchotsa. Kulephera kupuma chifukwa cha matendawa ndiko chifukwa chachikulu cha imfa mwa anthu ambiri omwe ali ndi CF.
Mabakiteriya Pseudomonas aeruginosa amakhala ndi moyo ponseponse. Mabakiteriyawa alipo pamtunda wouma ngati nthaka, zomera, madzi, madontho komanso nsapato za tenisi. Anthu ambiri amakumana ndi Pseudomonas aeruginosa tsiku lililonse popanda kutenga kachilomboka. Komabe, mwa anthu omwe samasokonezedwa kapena omwe ali ndi khungu kapena khungu, mabakiteriyawa angayambitse matenda.
Kuwonjezera pa kupha anthu omwe ali ndi CF, Pseudomonas aeruginosa amawotcha anthu omwe amawotcha komanso omwe akulandira mankhwala a chemotherapy . M'zaka zaposachedwapa, chiwerengero cha Pseudomonas aeruginosa matenda chifukwa cha zifukwa zina osati CF chachepa; pomwe, chiwerengero cha matenda pakati pa anthu omwe ali ndi CF sanasinthe.
Kodi Pseudomonas Aeruginosa Amachitiridwa Bwanji?
Zaka zapitazo, matenda a Pseudomonas aeruginosa aakulu mwa anthu omwe ali ndi CF amachiritsidwa m'malo mopweteka ndi mankhwala omwe amamwa mankhwala kapena kupiritsidwa ndi mankhwala ophera tizilombo .
Chakumapeto kwa zaka za m'ma 1990, ma antibiotic tobramycin, kapena TOBI, adapangidwa makamaka pofuna kuchiza matenda opatsirana a Pseudomonas aeruginosa. TOBI tsopano ndi mankhwala opatsirana a matendawa ndipo ndi mankhwala omwe amalembedwa kwa anthu omwe ali ndi cystic fibrosis.
Kodi TOBI N'chiyani?
TOBI ili ndi tobramycin. Tobramycin ndi mankhwala oteteza aminoglycoside omwe amagwiritsidwa ntchito pochiza matenda a Pseudomonas aeruginosa. Mankhwala a antibiotic amagwira ntchito pogwiritsa ntchito mapuloteni a bakiteriya. Pogwiritsa ntchito mapuloteni a Pseudomonas aeruginosa, TOBI amatha kusokoneza maselo a bakiteriya ndi envelopu motero amachititsa selo kufa.
Kodi TOBI Podhaler ndi chiyani?
TOBI poyamba ankagwiritsidwa ntchito pogwiritsa ntchito nebulizer . Makina a nebulizer ndi makina omwe amapanga nkhungu yabwino pofufuzira. Mu 2013, a FDA adavomereza TOBI Podhaler, yomwe ili ndi ufa wouma wothira wodzaza ndi tobramycin ya ufa wouma. Mankhwala atsopanowa amathandiza kuti wodwalayo adziwe tobramycin
Kodi TOBI kwa Aliyense?
Tsoka ilo, TOBI si aliyense. Anthu omwe ali ndi vuto lakumva, mavuto a impso, ndi mavuto a neuromuscular ayenera kuuzidwa TOBI mosamala kwambiri. Makamaka, aminoglycosides amadziwika kuti amataya ndi kumva, impso komanso kuchulukitsa matenda a neuromuscular monga myasthenia gravis. Kuwonjezera apo, anthu omwe ali ndi vuto lopatsirana ("allergic") mpaka aminoglycosides sayenera kutenga TOBI. Potsirizira pake, tobramycin, yomwe imagwiritsidwa ntchito ku TOBI, ndi yotchedwa teratogen ndipo ikhoza kuvulaza mwana yemwe ali ndi pakati.
Chitsime:
Smith, AL "Mankhwala Opatsirana Mankhwala Osakaniza Mankhwala: Kodi Ndi Mankhwala Otani? Kodi Dose Ndi Chiyani? Kodi Regimen? Kodi Kupanga Chiyani? " Journal ya Cystic Fibrosis . 2002 1: S189-S193. 22 June 2008.
Ramphal R. Matenda Chifukwa cha Mitundu ya Pseudomonas ndi Zogwirizana. Mu: Kasper D, Fauci A, Hauser S, Longo D, Jameson J, Loscalzo J. eds. Mfundo za Harrison za Internal Medicine, 19e . New York, NY: Hill ya McGraw; 2015.