Kuyanjana kwa Mankhwala Oopsa, Ofotokozedwa
Ngati mutenga mankhwala ovomerezeka ndi mankhwalawa kuti mupereke cholesterol chochuluka, malingana ndi zomwe mwauzidwa, dokotala wanu kapena katswiri wamasitolo angakhale akutsindika kuti musadye mphesa kapena kumwa zakumwa zam'madzi mukakhala pa mankhwala. Ngakhale kuti izi zingamveke bwino-bwanji chifukwa cha madzi a lalanje kapena mandimu-pali chifukwa chabwino kwambiri chochotsera zipatsozi.
Zipatso zamtengo wapatali zingagwirizane ndi mazithunzi ena mwa njira zomwe zingachititse kuti mankhwalawa asamagwire bwino komanso ngakhale kuyambitsa zotsatira zina zosayenera.
Chifukwa Chakumwa Champhesa ndi Malemba Sakusakanikirana
Amayi amodzi amadziwika kuti HMG-CoA reductase inhibitors, mawu omwe amamasulira momwe amachitira kuti achepetse mphamvu ya mafuta m'thupi mwa kutseka kachipuloteni kamene kamakhala kofunikira kuti apange cholesterol mu thupi lotchedwa HMG Co-A reductase. Ma Statins ndiwo mankhwala opatsirana kwambiri a cholesterol chifukwa, kuphatikizapo kuletsa cholesterol, zimakhudza mbali iliyonse ya mankhwalawa (zochepa za lipoproteins, kapena LDL ; lipoproteins, kapena HDL ; komanso triglycerides ) m'njira yabwino .
Mphesa yamphesa imakhala ndi bergamottin yomwe imagwira ntchito zosiyanasiyana m'thupi, kuphatikizapo cytochrome P-450 ndi P-glycoprotein. Njira zoterezi zimayambitsa kuswa malamulo (ndi zina mwa mankhwala) m'thupi thupi lingagwiritse ntchito mosavuta.
Ngati mudya zipatso zamphesa kapena kumwa zakumwa zam'mphepete mukamazitenga thupi, bergamottin akhoza kuteteza mavitaminiwa kuti aswe mankhwalawa. Zotsatira zake, zikhoza kuwonjezeka mu thupi lanu.
Maimidwe amodzi amatha kukhala owopsa, omwe angayambitse matenda aumphawi monga mapulaneti oopsa a chiwindi kapena chinthu chosavuta chomwe chimatchedwa rhabdomyolysis chomwe chimapangitsa kuti minofu iwonongeke, kumasula minofu m'magazi omwe angathe kuvulaza impso komanso ngakhale kuwonongeka kwa impso.
Sikuti ma statins onse sagwirizana ndi zipatso za pamphesa, koma zomwe ziri, zikuphatikizapo:
- Lipitor (atorvastatin)
- Mevacor (lovastatin)
- Zocor (simvastatin)
Zithunzi zina sizinawonetsedwe ngati zovuta pamene zimakhala ndi mphesa. Asayansi akuganiza kuti izi zikhoza kukhala chifukwa sichiphwanyika ndi njira zomwe zimayambitsa mankhwalawa. Zikuphatikizapo:
- Crestor (rosuvastatin)
- Pravachol (pravastatin)
- Lesco (fluvastatin)
- Livalo (pitavastatin)
Ngakhale Msuzi Wamphongo Ungakhale Wochuluka Kwambiri
Kafukufuku wambiri wasonyeza kuti pamafunika madzi okwanira 4 okha omwe amagwiritsa ntchito madzi a zipatso zamtengo wapatsogolo, kapena zipatso zonse zamtengo wapatali, zomwe zimapangitsa kuti thupi likhale ndi thupi. Choncho, ngati mutenga Lipitor, Mevacor, kapena Zocor ndi bwino kuthetsa zipatso za mphesa zonse. Ngati mumakonda kwambiri mphesa ndi kudana ndi lingaliro la kuzipereka, lankhulani ndi wothandizira zaumoyo wanu kuti akusinthireni ku statin kapena kuchepetsa mlingo wa zomwe mukuzitenga. Mwanjira imeneyo, mutha kukondwera ndi zipatso zanu zamtengo wapatali ndipo simungathe kuvutika ndi zotsatira zake zoipa. Kungakhale kwanzeru kukhala osamala ngati mutenga fano lina mwa kusadya mphesa kwa maola angapo musanayambe kumwa mankhwalawa.
> Zotsatira:
> Dipiro JT, Talbert RL. Pharmacotherapy: Njira ya Pathophysiological , 9th, 2014.
> Lee JW, Morris JK, Wald NJ, et al. "Mphukira Yamphesa ndi Statins." Am J Med 2016; 129: 26-29.
> MP ya Vaquero, Sanchez Muniz FJ, Redondo SJ et al. "Kugwiritsa Ntchito Mankhwala Ogwiritsa Ntchito Mankhwala Okhudzana ndi Mavitamini Okhudzana ndi Mankhwala Okhudzana ndi Mavitamini Okhudzana ndi Zochita Zachikhalidwe ndi Zopatsa Maonekedwe a Hypolipidaemic." Chithandizo ; 25: 193-206.