Cholestyramine ndi mankhwala osokoneza mafuta m'thupi omwe ali m'gulu la mankhwala a acid acid resin. Kafukufuku wasonyeza kuti cholestyramine makamaka imachepetsa LDL cholesterol ndi pafupifupi 15%. Cholestyramine sichioneka kuti imakhudza mbali zina za mbiri yanu yamadzimadzi koma ingapangitse maulendo a triglyceride nthawi zina.
Cholestyramine yasonyezedwanso kuti kuchepetsa kupititsa patsogolo kwa chitukuko cha atherosclerosis mu maphunziro angapo.
Komabe, sizinapangidwe pofuna kuteteza imfa kapena kulemala chifukwa cha matenda a mtima.
Cholestyramine poyamba inavomerezedwa kuti igwiritsidwe ntchito ndi Food and Drug Administration mu August 1973 pansi pa dzina, dzina lake Questran. Kuyambira pachivomerezo chake choyambirira, chakhala chikupezeka pansi pa mayina a malonda, Prevalite, Locholest, ndi ena.
Kodi Cholestyramine Ntchito N'chiyani?
Cholestyramine imamangiriza kuti bile amachiza m'matumbo aang'ono, kuteteza kubwezeretsa kwawo. Mafuta acids amachokera ku cholesterol ndipo amafunikira kuthandizira ndi zakudya za mafuta zomwe zimadya zakudya zanu. Pamene cholestyramine imamangiriza ku bile acids, iyo imatha ndipo imatha kubwezeretsedwa. Kuti apange mavitamini ambiri, cholesterol adzachotsedwa m'magazi ndi kusandulika kukhala bile acid. Ntchitoyi imachepetsa makilogalamu anu.
Kodi Muyenera Kutenga Cholestyramine Bwanji?
Muyenera kutenga cholestyramine monga mwadongosolo ndi wothandizira zaumoyo wanu.
Cholestyramine imapezeka papepala, ndipo imaphatikizidwa mu mapepala ang'onoang'ono, amodzi kapena mu chidebe chachikulu.
Wothandizira zaumoyo wanu angayambe paziwerengero zazing'ono ndikuwonjezera mlingo wanu pogwiritsa ntchito yankho lanu ku mankhwala ndi zotsatira. Mlingo woyenerera woyambira ndi imodzi yokha kapena mapaketi (4 magalamu cholestyramine) kamodzi kapena kawiri patsiku.
Izi zikhoza kuwonjezeka mpaka mlingo wa sikisi pa tsiku. Mlingowo uyenera kusakanizidwa ndi madzi osachepera 2, madzi a zipatso (kapena opanda zamkati), maapulosice, msuzi wochepa thupi, kapena chakumwa china musanamwe. Muyenera kugwiritsira ntchito zonse zakumwa zomwe zili ndi cholestyramine kuti mupeze mankhwala okwanira. Cholestyramine iyenera kutengedwa ndi chakudya.
Ndani Saliyenera Kuzitenga?
Chifukwa cha zigawo zake, pali zina zomwe cholestyramine sayenera kutengedwa. Izi ziphatikizapo:
- Anthu omwe kale anali ndi vuto la cholestyramine kapena chilichonse cha zigawo zake sayenera kutenga cholestyramine.
- Aliyense yemwe watulukira kuti ali ndi vuto la biliary, kumene bile zamadzimadzi sizili zobisika m'matumbo aang'ono.
Zinthu Zofunika Kuziwona
Ngati mukugwiritsa ntchito cholestyramine, wothandizira zaumoyo wanu angafunike kukuyang'anani mwatcheru ngati muli ndi matenda ena omwe angapangidwe mwa kumwa mankhwala. Ngati muli ndi zifukwa izi zotsatirazi, wothandizira zaumoyo wanu angasankhe kukuyambitsa cholestyramine koma ayenera kukuyang'anitsani kuti mudziwe ngati mungatenge cholestyramine kapena kuti musakuvulazeni.
Mavuto awa ndi awa:
- Masamba akuluakulu a triglyceride. Cholestyramine yasonyezedwa kuti iwonjeze magulu a triglyceride mu maphunziro. Ngati muli ndi triglycerides yapamwamba, wothandizira zaumoyo wanu adziwunika machitidwe anu kuti asatengeke kwambiri.
- Kukhala ndi kudzimbidwa kosatha. Cholestyramine ingaipitse vutoli ngati mukuvutika ndi kudzimbidwa.
- Mimba. Cholestyramine amadziwika ngati Mimba ya Mimba C. Ngakhale kuti sizinakhale zopitilira zochuluka zowunika momwe polojekiti ikuyendera ndi chitetezo cha cholestyramine mwa amayi omwe ali ndi pakati. Popeza mankhwalawa amachepetsa kuyamwa kwa mavitamini ena, zina mwazigawo zowonjezera mavitamini sizingatheke pamene zimatenga cholestyramine. Wopereka chithandizo chaumoyo wanu adzapanga chisankho ngati simukuyenera kumwa mankhwalawa kapena ayi.
Zotsatira Zotsatira
Kutenga ndiko mbali yowonekera kwambiri pamene mutenga cholestyramine. Izi nthawi zambiri zimatha ndi mankhwala opitilira. Wothandizira zaumoyo wanu angasankhe kuchepetsa mlingo wanu kapena kukupatsani mankhwala kuchipatala ngati zotsatira zake zimakhala zovuta kwambiri. Zotsatira zina zofala zimaphatikizapo:
- Kutseka
- Flatulence
- Nausea
- Kukhadzula
- Kuthamanga
- Kupweteka m'mimba ndi kuvutika
Zotsatira zina zakhala zikudziwika chifukwa chogwiritsa ntchito cholestyramine nthawi yaitali. Kuwonjezereka kwachidziwitso kumatuluka pakapita nthawi chifukwa cha kuchepa kwa vitamini K. Kuwonjezera apo, kusinthika kwa michere ya chiwindi ndi kuwonongeka kwa dzino lazitsulo kungayambe chifukwa cha kumwa mowa kwa mankhwala kapena kubweretsa pakamwa pakamwa.
Mankhwala othandizana
Mankhwalawa akhoza kuthandizana ndi cholestyramine mwa kuchepetsa kuchuluka kwa mankhwala omwe alowetsedwa m'magazi anu. Wopanga amalimbikitsa kuti asamamwe mankhwala ena kapena kupatsirana ola limodzi kapena ola limodzi kapena asanu pambuyo pa cholestyramine. Ngati mukuyenera kutenga mankhwala ena kapena zowonjezereka m'munsimu, wothandizira zaumoyo wanu angafunikire kusintha mlingo wanu kapena nthawi yomwe mumatenga, kuyang'anitsitsa kwambiri zotsatira zake, kapena kusiya ntchito yanu yonse pamodzi:
- Mahomoni a chithokomiro
- Lanoxin (digoxin)
- Mankhwala oletsa kubadwa
- Mankhwala othandiza kuchepetsa mafuta m'thupi (kuphatikizapo fibrates, ezetimibe, statins)
- Mankhwala otsutsana ndi zotupa (NSAIDs)
- Corticosteroids
- Diuretics (kuphatikizapo hydrochlorothiazide, spironolactone, furosemide)
- Coumadin (warfarin)
- Mavitamini osungunuka (vitamini A, D, E, ndi K)
- Mankhwala othawa, monga Dilantin (phenytoin) ndi phenobarbital
Palinso mankhwala ena angapo omwe angathe kuthandizana ndi cholestyramine, yomwe ili pamwambapa. Choncho, muyenera kumapanga mankhwala othandizira zaumoyo kuti azidziŵa mankhwala aliwonse oyenera komanso odalirika, ndi mankhwala omwe mukuwutenga. Izi zidzathandiza wothandizira zaumoyo wanu kuti adziwe zoyenera kuchita pakati pa cholestyramine ndi mankhwala ena.
Pansi
Cholestyramine ndi imodzi mwa mankhwala otsika kwa mafuta m'thupi omwe amavomereza ku US. Amagwiritsiridwa ntchito kwambiri kuti achepetse cholesterol chanu cha LDL koma sichikuwonetseratu kuti amapereka imfa kapena zovuta kuchokera ku matenda a mtima monga mankhwala ena omwe amatsitsa pamsika. Muyenera kulola wothandizira zaumoyo wanu kudziwa ngati mukukumana ndi mavuto aliwonse pogwiritsa ntchito cholestyramine chifukwa mawonekedwe a ufawo akhoza kukhala ndi kukoma kokoma kumene kungakhale kovuta kumeza kwa anthu ena. Chifukwa cholestyramine imakhudza kwambiri ma CD ya cholesterol anu, wothandizira zaumoyo wanu angasankhe kuwonjezera zochiritsira zina - monga statin kapena fibrate - kupatsirana pansi kwa lipiden .
Zotsatira:
Choyamba (Cholestyramine). Smith Laboratories Yopangika. Maple Grove, MN. Revised 4/2015.
Dipiro JT, Talbert RL. Pharmacotherapy: Njira ya Pathophysiological, 9th, 2014.
Micromedex 2.0. Truven Health Analytics, Inc. Greenwood Village, CO. Ipezeka pa http://www.micromedexsolutions.com.