Matenda a POEMS ndi matenda a magazi omwe amakhudza ziwalo zambiri za thupi ndipo amachititsa zizindikiro zambiri. Zimakhudza amuna ndi akazi ndipo kawirikawiri zimayamba pambuyo pa zaka 50, ngakhale zikhoza kuchitika pa msinkhu uliwonse. Sidziŵika momwe nthawi zambiri matenda a POEMS amachitikira chifukwa zimakhala zovuta kudziwa bwinobwino. Chifukwa chake sichidziwika.
Zizindikiro
Mphindi POEMS imaimira:
- P - polyneuropathy, kutanthauza zizindikiro za mitsempha monga kufooka, kugwedeza, ndi / kapena kufooka kwa manja ndi mapazi
- O - zilembo, kutanthauza ziwalo zotambasula, kawirikawiri chiwindi, ntchentche, kapena zam'mimba. Pafupifupi 15 peresenti ya anthu omwe ali ndi matenda a POEMS ali ndi Castleman matenda (matenda a mimba).
- E - endocrinopathy, kutanthawuza kusintha kwa kupanga mahomoni. Zizindikiro monga matenda a shuga , kusowa mphamvu , kusiya msambo ( amenorrhea ), kuchepa kwa chithokomiro (hypothyroidism), ndi / kapena kukula kwa anyamata (gynecomastia) kungakhalepo.
- M - monoclonal gammopathy kapena monoclonal plasma kuchulukitsa matenda, onse awiri amatanthauza maselo osapitirira magazi
- S - khungu limasintha monga kukula kwa khungu (hyperpigmentation); tsitsi lowonjezera (hypertrichosis) pamaso, miyendo, ndi chifuwa; khungu likulumpha ndi kulimbitsa, kutupa (edema) ya miyendo ndi mapazi, kuyera kwa misomali.
Anthu angathenso kumva, kutopa, zowawa komanso zowawa, kapena kusintha kwa masomphenya, pakati pa zizindikiro zina.
Kudziwa
Matenda a POEMS angapangidwe malinga ndi kuunika kwa wodwalayo komanso mbiri yake yachipatala. Mayeso a magazi monga chiwerengero chathunthu cha magazi (CBC) ndi serum proteinelerororesisis amachitidwa pofuna kuyang'ana zosavuta, monga kuyesa mkodzo. Mahomoni a chithokomiro, mazira a magazi, ndi maselo a estrogen m'magazi amayesedwa kuti azindikire zolakwika.
Mphuno wa mafupa ndi / kapena fupa x-ray akhoza kuchitidwa kuti athandizidwe.
Munthu amaonedwa kuti ali ndi vuto la POEMS ngati "P" (polyneuropathy) ndi "M" (zopanda magazi zamapuloteni) zilipo limodzi ndi zilonda za sclerotic (scarring) kapena Castleman matenda. Anthu ambiri adzakhala ndi zizindikiro zina za matendawa. Chifukwa chakuti madokotala ambiri sadziwa bwino matenda a POEMS, zotsatira zowopsa za magazi zimayambitsa matenda osokoneza bongo a myeloma, kapena zizindikiro za polyneuropathy zimayambitsa matenda osokoneza maganizo omwe amachititsa kuti thupi lisamayende bwino kwambiri (CIDP).
Chithandizo
Chithandizo cha matenda a POEMS chimadalira chithandizo cha matenda opatsirana pogwiritsa ntchito magazi. Anthu ambiri amalandira mankhwala osiyanasiyana monga:
- Kuchiza ma ARV
- Mankhwala a corticosteroid monga prednisone
- Chemotherapy
- Hormone m'malo mwa mahomoni omwe ali otsika kwambiri
- Kuchiza thupi
- Kugwiritsira ntchito mafupa a mafupa
Akatswiri monga katswiri wa zamaganizo (dokotala wa mantha), wodwala matenda a magazi (dokotala), dermatologist (dokotala wa khungu), ndi dokotala wodziwika bwino wa mankhwala (hormone gland dokotala) nthawi zambiri amagwira ntchito yosamalira munthu amene ali ndi matenda a POEMS.
Zotsatira:
Dispenzieri, Angela. "POEMS Syndrome." Hematology 2005 (2005): 360-367.
Mayi William Q. Lacy, S. Vincent Rajkumar, Terry M. Therneau, Dirk R. Larson, Philip R. Greipp, Thomas E. Witzig, Rita Basu, Guillermo A. Suarez, Rafael Fonseca, John A. Lust, & Morie A. Gertz. "Matenda a POEMS: kutanthauzira ndi zotsatira za nthawi yaitali." Magazini 101 (2003): 2496-2506.
"Zizindikiro za POEMS Syndrome." Kuchiza kwa POEMS Syndrome ku Mayo Clinic. Mchipatala cha Mayo. 22 May 2007
Chan, Joanna, & Wingfield Rehmus. "POEMS Syndrome." eMedicine. 15 Dec 2006. WebMD. 22 May 2007