Mafuta, omwe amadziwikanso kuti mankhwala okhutira ndi asidi, ndi gulu la mankhwala osokoneza bongo omwe amatha kukhudza mbali zonse za mbiri yanu.
Njira imene fibrates yotsika kwa cholesterol imakhala yovuta. Zomera zimalimbikitsa puloteni yotchedwa peroxisome yolandirira-receptor alpha (PPAR-alpha). Mapuloteniwa amatha kuyambitsa tizilombo toyambitsa matenda, lipoprotein lipase, zomwe zimachepetsa kuchuluka kwa apolipoprotein C-III m'thupi.
Pamapeto pake, izi zimapangitsa kuti mapangidwe apangidwe a VLDL ndi a triglycerides amachepetse komanso kuwonjezereka kwa lipids. Zomera zimalowanso m'magulu a HDL powonjezera kuchuluka kwa apolipoprotein AI ndi A-II omwe amapangidwa mu thupi.
Pakalipano mankhwala awiri a fibrate amavomereza kuti agwiritsidwe ntchito ndi Food and Drug Administration (FDA) ku United States:
- Gemfibrozil (Lopid)
- Fenofibrate (Tricor)
Mafuta amadziwika kwambiri chifukwa chochepetsa triglycerides ndi kuchulukitsa HDL cholesterol. Komabe, zimatha kusintha mbali zonse za mbiri yanu. Kawirikawiri, fibrates ikhoza:
- Lembetsani makilogalamu a LDL cholesterol ndi 5 peresenti mpaka 20 peresenti.
- Lonjezerani cholesterol yanu ya HDL mwapakati pa 10 peresenti mpaka 35 peresenti.
- Lembetsani masentimita anu a triglyceride ndi 20 peresenti mpaka 50 peresenti.
Pofuna kuti thupi lanu liziyenda bwino, fibrates ikhoza kuthandizidwa yokha kapena kuphatikizapo othandizira ena, monga statins kapena omega-3 fatty acids.
Momwe Muyenera Kutengera Kutentha
Muyenera kutenga fiber yanu monga momwe mwafunira ndi wothandizira zaumoyo wanu ndipo muyenera kutsimikiza kuti musaphonye mlingo uliwonse. Mankhwala onse a fibrate amapezeka papepala ndipo amatengedwa ndi pakamwa. Ngakhale mutatha kutenga mitundu yonse ya fibrates kapena wopanda chakudya; Komabe, kafukufuku wasonyeza kuti kutenga fibrate, gemfibrozil, ndi chakudya kumathandiza kuwonjezera kuyamwa kwake.
Muyeneranso kuonetsetsa kuti musaphonye malo omwe mwasankha ndi wothandizira zaumoyo wanu, chifukwa adzafunika kudziwa ngati mankhwalawa akukuthandizani kapena ayi. Wothandizira zaumoyo wanu angafunikire kusintha kusintha kwa mankhwalawa, malinga ndi momwe mumamvera mankhwala. Pogwiritsa ntchito fibrates - kapena mankhwala ena amodzi ochepetsa kutupa mankhwala - muyenera kukhalanso pafupi ndi zakudya kuti muchepetse cholesterol ndi triglycerides.
Kodi Pali Zotsatira Zonse Zomwe Mungayang'ane?
Ngakhale kuti fibrates imaloledwa bwino pakati pa anthu omwe amawatenga, mukhoza kutenga zotsatira zina mwa kuwatenga, Zotsatira zoyipa zomwe zimawoneka zikuphatikizapo kukumana ndi vuto la m'mimba, monga kunyozetsa, kutsegula m'mimba, ndi ululu m'mimba. Zotsatirapozi nthawi zambiri zimakhala zofewa ndipo, nthawi zambiri, zimachoka mutangoyamba wanu fibrate.
Nthaŵi zina, fibrates ingapangitse mavitamini a chiwindi, kotero kuwonjezera pa lipids wanu, wothandizira zaumoyo wanu adzawonekeranso mavitamini a chiwindi nthawi ndi nthawi. Ngati muli ndi matenda a ndulu, muyenera kulola wothandizira zaumoyo wanu kudziwa, popeza pali chiopsezo chochepa chokhala ndi mitsempha yamtunduwu pamene akudya fiber. Ziphuphu zingayambitsenso matenda omwe amatchedwa rhabdomyolysis.
Ngakhale kuti sizowonjezereka, chiopsezo chotenga matendawa pamene chimatenga fetiti chimakula ngati mukumwa mankhwala ena pamodzi ndi fibrate kapena muli ndi matenda enaake.
Fodya ikhoza kuwonjezera mwayi wanu wokhala ndi magazi ngati mutenga magazi ochepa, monga Coumadin ( warfarin ). Chifukwa cha ichi, wothandizira zaumoyo wanu angasinthe mlingo wanu pamene akutenga fibrates.
Zotsatira zomwe zimapezeka ndi fibrates nthawi zambiri zimakhala zofewa, koma ziyenera kubweretsedwa kwa wothandizira zaumoyo wanu ngati zimakhala zovutitsa kapena zotsalira kwa nthawi. Muyenera kulola wothandizira zaumoyo wanu kuti adziwe mankhwala aliwonse amene mukuwagwiritsa ntchito - kuphatikizapo mankhwala kapena mankhwala omwe ali nawo kuti athe kukuyang'anirani pakapita nthawi.
Zotsatira:
> Dipiro JT, Talbert RL. Pharmacotherapy: Njira ya Pathophysiological, 9th, 2014.
Malloy MJ, Kane JP. Agent Ntchito Dyslipidemia. Mu: Katzung BG, Trevor AJ.eds. Basic & Clinical Pharmacology, 13e . New York, NY: Hill ya McGraw; 2015.