Mtumiki wa mankhwala mu ubongo Wanu umene umayambitsa matendawa
Tanthauzo
Zapangidwe m'dera la ubongo lotchedwa hypothalamus , orexin ndi amodzi a mankhwala, kapena a neurotransmitter, omwe amakhudza ubongo ndipo amachititsa kuti munthu adye chakudya, akhale wogalamuka komanso agwiritse ntchito mphamvu. Asayansi anapeza orexin mu 1998, ndipo akhala akufufuzira udindo wawo mu tulo ndi kudzudzula, komanso chithandizo cha matenda ogona.
Orexin, yomwe imatchedwanso hypocretin, ndi mbali ya mankhwala omwe amatchedwa horitone ya excitatory neuropeptide. Pali mitundu iwiri ya peptide yomwe ili ndi mankhwala ofanana, omwe amadziwika kuti orexin-A (kapena hypocretin-1) ndipo winayo ndi orexin-B (kapena hypocretin-2). Kulephera kwa Orexin kungawononge thupi kuti likhalebe maso komanso kugona, vuto lomwe lingabweretse vutoli .
Orexin ndi Narcolepsy
Kwa anthu amene ogona amawongolera bwino, orexins amamasulidwa akakhala maso ndipo amathandiza kuwonjezera masewera olimbitsa thupi omwe amachititsa kuti anthu azikhala okonzeka komanso kuletsa kugona kwa REM - tulo tofa nato pamene maloto amapezeka.
Munthu wina akakhala ndi vuto lopweteka matendawa, lomwe limakhala ndi kugona kwa usana ndi kugona tulo popanda kuchenjeza, ndi chifukwa chakuti ma neuron awo opangidwa ndi orexin amwalira. Popanda orexins, munthu yemwe ali ndi vuto lopweteketsa matenda sangathe kuchepetsa kugona kwa REM. Nthaŵi zina, kulota kumene kumachitika nthawi ya kugona kwa REM kungatheke pamene munthu agalamuka, zomwe zimapangitsa kuti azisokoneza maloto.
Koma bwanji orexins amamwalira poyamba? Ochita kafukufuku amakhulupirira kuti vutoli limayamba chifukwa cha kusokonezeka kwa orexin neurons. Kawirikawiri, anthu omwe ali ndi matendawa amatha kuchuluka kwa ma antibodies omwe amamenyana ndi streptococcus, yomwe ndi mabakiteriya omwe amachititsa msempha . Izi zikusonyeza kuti kuukira kwadzidzidzi kumayambitsidwa ndi mliri kapena matenda ena achisanu, makamaka chifukwa chakuti nthawi zambiri amatha kubwerera kumapeto kwa nyengo yachisanu kapena kumayambiriro kwa chilimwe.
Kuchitira Orexin Kulimbana ndi Kugona
Ngati kusowa kwa orexin kumayambitsa matenda ogona, ndizomveka kuti orexins ingathandizenso kuti mukhale maso, molondola? Gulu la mankhwala osokoneza bongo, lotchedwa orexin receptor antagonists, posachedwapa lakonzedwa kuti athetse vuto la kugona, monga kusowa tulo. Zothandizira izi zothandizira kugwiritsira ntchito orexin, zomwe zimaletsa kuwonetsa kwa orexin mu ubongo. Orexin imathandiza kuti anthu akhale maso komanso atcheru, motero kuwateteza kumalimbikitsa kugona.
Odwala agonist odwala receptor amasiyana ndi mankhwala ena ogwiritsira ntchito mankhwala omwe amagwiritsidwa ntchito pazinthu zosiyanasiyana komanso m'magulu osiyanasiyana. Matenda osokoneza bongo, ogulitsidwa pansi pa dzina lakuti Belsomra, ndiye woyamba wa mankhwalawa kuti akhalepo.
Onetsetsani izi zowonjezera kuti mudziwe zambiri za matenda osokoneza bongo ndi mavuto ena ogona:
Kusanthula kwa Khunyu Kwambiri
Mayesero Odziŵa Kuvutika kwa Kugona
Zindikirani Zizindikiro ndi Zovuta Zopweteka
Kufotokozera za Matenda Ogonana Ogonana
Mapiritsi Akugona Angathandize ndi Chisokonezo Koma Kodi Akuyenera?
Mfundo Zinayi Zofotokozera za Kusagwedezeka
Zotsatira:
Gawa la Sleep Sleep Medicine ku Sukulu ya Zamankhwala ya Harvard. (2013, January 19). The Science of Narcolepsy. Inabweretsedwa pa February 06, 2016.
National Sleep Foundation. (nd). Otsutsana ndi odwala a Orexin: A pulogalamu yatsopano ya mapiritsi ogona. Inabweretsedwa pa February 06, 2016