CD20 ndi chizindikiro cha CD-molekyu pa selo yomwe ingagwiritsidwe ntchito poyesa ndikuyimira selo inayake m'thupi. CD20 imapezeka pamwamba pa maselo a B, koma tiyeni tibwerere ndikudziwitsa izi.
Kodi Makalata A CD Ndi Chiyani?
Zizindikiro za CD ndi mamolekyu amene amapezeka pamwamba pa maselo m'thupi lathu. Mukhoza kumva iwo akutchedwa antigen - ndipo antigen ndi chinthu china chilichonse chomwe chili pamwamba pa selo chomwe chimatha kudziwika ndi chitetezo chathu cha mthupi.
Mwachitsanzo, maselo oyera amagazi amatha kudziwa ma antigen omwe ali pamtunda wa mabakiteriya ndipo maselo oyera amatha kuchita zinthu zomwe zimawoneka kuti ndizoopsa.
Selo lililonse m'matupi athu liri ndi chizindikiro cha CD, ndipo zonsezi ndi zoposa 250 ma antigen. Mawu akuti CD amaimira magulu a kusiyana - komanso, njira imodzi yomwe maselo osiyanasiyana angaulidwe padera. Kuzindikira ma CD amenewa kungakhale kofunika makamaka pamene simungathe kuzindikira mtundu wa selo.
Makalata a CD, B, ndi Tells
Mafuta a khansa ndi khansa ya mtundu wa selo loyera la magazi lotchedwa lymphocytes. Pali mitundu iwiri ikuluikulu ya ma lymphocytes - ma lymphocytes B kapena maselo B , ndi ma lymphocytes T kapena maselo T. Mitundu yonse ya ma lymphocyte imateteza matupi athu ku matenda.
Ma maselo a B ndi ma T ali ndi ntchito zosiyanasiyana, ndipo khansa ya maselo onse a B amachita mosiyana ndi khansa ya maselo B.
Ngakhale zosiyana zonsezi, zingakhale zovuta kufotokoza kusiyana pakati pa 2 pansi pa microscope. Mtundu wofanana ndi mapasa awiri ofanana omwe amachita mosiyana kwambiri ndikuyankha anthu mosiyana koma amawoneka mofanana.
Kodi CD20 ndi chiyani?
CD20 ndi antigen yomwe imapezeka pamwamba pa maselo a B osati ma maselo T.
Chitsanzo cha momwe CD-20 ingagwiritsidwiritsidwire ntchito powuza maselo akuperekedwa apa:
Pali khansa 2 yosiyana kwambiri yomwe imawoneka ngati mapasa omwe ali pansi pa microscope, koma ali ndi matenda osiyana kwambiri ndipo amachitapo kanthu mosiyana ndi mankhwala: Kufalitsa kwakukulu B cell lymphoma (DLBCL) ndi khansa ya maselo B. Pansi pa microscope maselo amawoneka ngati maselo a khansa T omwe amapezeka mu chipinda chachikulu cha cell lymphoma (ALCL) . Zonsezi zimakhala ndi zazikulu, "maselo oyang'ana khansa" ndipo sangathe kudziwika bwinobwino. CD20 ingagwiritsidwe ntchito kusiyanitsa pakati pa khansa ziwirizi mu zotsatira zowonetsera kuti CD20 ingakhale yabwino kwa DLBCL koma yoipa kwa ALCL.
Kodi Zimayesedwa Bwanji?
Njira yapadera yotchedwa immunohistochemistry (IHC) imagwiritsidwa ntchito pozindikiritsa CD20 ndi kudziwa ngati maselo oyera a khansa yoyera kwambiri (lymphocyte makamaka) ndi B-cell kapena T-cell.
Kodi Zimakhudzidwa Bwanji?
Kuchiza ndi kutsegula kwa B-cell ndi T-cell lymphomas nthawi zambiri zimasiyana.
Gawo latsopano la mankhwala omwe amatchedwa antioclonal antibodies amagwira ntchito bwino kwambiri kwa malimymasi ena. Monga matupi athu amapanga tizilombo toyambitsa matenda kumenyana ndi mabakiteriya ndi mavairasi, ma antibodies monoclonal ndi ma antibodies opangidwa ndi anthu opangidwa kuti athetse maselo a khansa.
Ndipo monga momwe matupi athu amapangira tizilombo toyambitsa matenda omwe amadziwa ma antigen pa mabakiteriya ndi mavairasi, ma antibodies ameneŵa amadziŵa ma antigen pa maselo a khansa; Pankhaniyi, CD20.
Kugwiritsa ntchito antioclonal antibody yomwe imamangiriza ku CD20, imangogwira ntchito yotsutsana ndi khansa yomwe imakhala ndi antigen anti CD20 pamwamba, monga ALCL.
Mankhwala a Monoclonal Antibody ndi CD20
Pali ma antibodies ambiri omwe amapezeka tsopano. Mankhwala a monoclonal amene amachititsa maselo a B cell ndi ma leukemias ndi CD20 antigen pamwamba pa maselo ndi awa:
- Rituxan (rituximab)
- Zevalin (ibritumomab tiuxetan)
- Bexxar (tositumomab)
- Gazyva (obinutuzumab)
- Arzerra (ofatumumab)
Ngakhale kuti onse amamanga CD20, pali kusiyana pakati pa ma antibodies awa. Ena amatchedwa chimeric monga rituximab, zomwe zikutanthawuza kuti bio-engineers amagwiritsa ntchito 'kusakaniza zipangizo zomanga' kuti apange anti-antibody, ena, mtundu wina; ena amatsitsimutsa (obinutuzumab) ndipo ena ndi anthu (ofatumumab), kutanthauza kuti ziwalo zonse zimachokera ku mapuloteni a anthu. Kenaka, chinthu china chosiyana ndi chakuti zina zimagwirizanitsidwa ndi radioactive (ibritumomab tiuxetan ndi tositumomab).
Kulimbana ndi Lymphoma
Pamene mwafika pamasamba awa, mukuyendabe patsogolo pakukhala nawo mwachangu mu chisamaliro chanu. Kafukufuku apeza kuti kuphunzira zambiri za matenda anu ngati n'kotheka , komanso kusewera nawo mbali, mumawathandiza kuthetsa nkhawa za khansa komanso kungakuthandizeni ndi zotsatira. Pitani kwa achibale ndi abwenzi. Fufuzani malo abwino pa intaneti a anthu omwe ali ndi khansa ya m'magazi ndi lymphoma - anthu omwe mungawathandize 24/7 kuti awathandize komanso ndi mafunso. Ndipo onetsetsani kuti ndinuwemwini wanu pa chisamaliro chanu cha khansa . Mankhwala akusintha ndipo oncologists amangokhalira kulekerera koma kuyembekezera kuti azigwira ntchito limodzi ndi inu kuti akuthandizeni pulogalamu yamankhwala yomwe ili yabwino kwa inu monga munthu.
Zotsatira:
National Cancer Institute. Mankhwala Osapanga Matenda Aakulu Osati Hodgkin - Health Professional Version (PDQ). Kusinthidwa 01/15/16. http://www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment-pdq