Tanthauzo la Engraftment ndi Chomwe Chikuchitika Mu Kusuntha kwa Mthunzi Wako
Kuikapo maselo m'thupi lanu kumatulutsira maselo a mitsempha ndi pamene thupi lanu limavomereza fupa la fupa kapena maselo amkati, ndipo amayamba kupanga maselo atsopano a magazi ndi maselo a chitetezo cha m'thupi. Imeneyi ndi sitepe yopambana yopanda maselo.
Kodi N'chiyani Chimachitika Pakati pa Cell Stem kapena Bone Marrow Kukulitsa?
Mankhwala a khansa akhoza kuchitidwa mwa kupha mafupa anu ndi mafupa am'madzi ndi ma radiation kapena chemotherapy kuti awononge maselo a khansa.
Anthu omwe ali ndi mitundu ina ya khansa amafunikanso kusinthitsa maselo chifukwa cha zotsatira za dzuwa kapena chemotherapy. Mankhwalawa akhoza kukhala ndi zotsatira zovulaza mafupa awo ndi maselo a tsinde, ndipo ngati kuwonongeka kuli kochulukirapo, kukumbidwa kumafunika kutibwezeretsa ntchito ya fupa lawo. Anthu ena angafunikire kupalasa mafuta chifukwa chodziwidwa ndi ma radiation kapena mankhwala kapena zinthu zina zomwe zimawononga mafupa awo.
Pakati pa maselo opangira maselo, mafupa a wolandirayo amaonongeka ndi mankhwala enaake kapena popanda ma radiation mpaka pomwe sangathe kugwira ntchito. Zimapangitsa kuti asapange maselo ofiira a magazi, mapiritsi kapena maselo oyera a magazi. Ndipotu, kuwonongeka kwakukulu kwambiri kotero kuti wodwalayo adzafa pokhapokha ngati mchere wawo ukubwezeretsedwanso ndi kulowetsedwa kwa maselo amkati, kaya kuchokera kwa wopereka, kapena maselo omwe wodwalayo omwe anasonkhanitsidwa kale ndi kusungidwa.
Pamene maselo opangira operekedwa amaperekedwa kwa wolandila, amapeza njira yopita mumtambo m'mapfupa. Pamene ali pamalo ndikuyamba kubereka, engraftment imapezeka. Maselo ammunsi amatha kupanga kachilombo kakang'ono ka chitetezo champhamvu komanso chitetezo cha mthupi kwa wolandira.
Kodi N'chiyani Chimachitika Panthaŵi ya Engraftment?
Maselo amathithi kapena msupa amaperekedwa ngati kuikidwa magazi.
Pakangotha masiku ochepa mutatha kuziika, maselo osungunukawo amasamukira ku fupa ndikuyamba njira yopangira maselo a magazi. Zimatengera masiku 12 mpaka 15 mutatha kulowetsedwa kwa maselo amkati kuti ayambe kupanga maselo atsopano a magazi. Mankhwala omwe amatchedwa kuti colony-stimulating factors angaperekedwe panthawiyi kuti apititse patsogolo kupanga maselo a magazi. Maselo atsopano amaphatikiza maselo ofiira ofiira, maselo oyera ndi maselo. Pakangoyamba kupanga, engraftment akuti ichitika.
Mawerengedwe anu a magazi onse adzawunika nthawi zambiri kuti awone ngati zolembera zikuchitika. Kuwonjezereka kosavuta ndi kosalekeza kwa maselo a maselo a magazi kumasonyeza kuti engraftment ikuchitika. Kumayambiriro kwa njirayi, kuwerengera kwathunthu kwa maselo amagazi kudzawonetsa kuwuka kwa maselo oyera a magazi ndi kusintha kuchokera ku ma lymphocytes kupita ku neutrophils.
- Chiwerengero cha neutrophil (ANC) cha 500 kapena kuposa kwa masiku atatu mzere ndi chizindikiro cha engraftment. Mavitamini a mitsempha ya m'magazi kapena a m'magazi (PBSC) omwe amalandira, mankhwala osokoneza bongo amatha kuchitika patangotha masiku 10 kuchokera pamene amakoka koma amapezeka masiku oposa 14-20.
- Chiwerengero cha mapulogalamu a 20,000 mpaka 50,000 ndi chizindikiro cha cholembera cha platelet. Mafuta kapena PBSC alandira, cholembera pamatumba nthawi zambiri chimapezeka patangopita kanthawi kochepa.
Mpaka kutsekemera kwatha, pali chiopsezo chachikulu cha matenda, kuchepa kwa magazi m'thupi, ndi kutuluka kwa magazi zomwe zimayambitsa - zonse zomwe zimayambitsidwa ndi chiwerengero chochepa cha maselo a magazi. Pofuna kuthana ndi vutoli, operekera operekera akhoza kupatsidwa magazi ofiira ndi mapiritsi a pulogalamu pa nthawi yochira. Zotsatira za mankhwala apamwamba kwambiri komanso kutayika kwa maselo a magazi zimafooketsa chitetezo cha thupi, kotero kuti pakatha masabata awiri mpaka 2-4, odwala amakhala ndi kachilombo koyambitsa matenda. Choncho, ma antibayotiki amauzidwa kuti ateteze matenda.
Zitha kutenga miyezi yochuluka kwa zaka chimodzi kapena ziwiri kuti thupi liziyambiranso bwino pambuyo pa engraftment.
Kaŵirikaŵiri imapezeka mofulumira kwa ma autologous transplant kusiyana ndi zopereka zopereka. Mudzayezetsa magazi kuti maselo apangidwe akhale maselo atsopano m'malo mokhala ndi maselo a khansa. Mwinanso mungakhale ndi fupa la fupa la fupa kuti muwone mmene mzere watsopano ukugwirira ntchito.
Chomaliza chomaliza chimagwiritsidwa ntchito mokwanira mafupa a mitsempha ya maselo ofiira, maselo oyera ndi maselo, kuphatikizapo mitundu yonse ya maselo oyera - lymphocytes, granulocytes ndi monocytes.
Mawu Ochokera
Nthawi zobwezeretsa zimasiyanasiyana munthu ndi munthu. Asanafike kuchipatala, amatha kudya ndi kumwa madzi okwanira, alibe fever, alibe kusanza kapena kutsekula m'mimba, ndipo ali ndi maselo otetezeka a maselo onse a magazi. Omwe amatha kulumikiza amatha kutopetsa mosavuta ndi kufooka kwa miyezi, komabe mbali zina chifukwa zimatengera nthawi kuti chitetezo cha mthupi chitengeke.
Anthu ena angafunikire kukhalabe m'chipatala nthawi yaitali ngati mavuto akukula. Kulephera kusinthanitsa ndi zovuta koma zovuta kwambiri za mafupa osakaniza mafupa, ndipo zimatha kukula pamene maselo atsopano sakukula kapena mawonekedwe a chitetezo cha m'thupi amakana maselo. Nthawi zambiri, gulu lanu lachipatala lidzakuuzani za zomwe mungasankhe.
> Zosowa
> Kekre N, Antin JH. Mankhwala opangira maselo amtundu wa maselo a m'kati mwazaka makumi awiri mphambu makumi awiri (21): kusankha wosankhidwa bwino pamene palibe mkaka wangwiro. Magazi . 2014; 124 (3): 334-43.
> Chang L, D Frame D, Braun T, et al. Matendawa amatengera osauka
zotsatira. Kusamba Magazi Amagazi Amagazi . 2014; 20 (9): 1407-1417.
> National Cancer Institute. Maselo ofunika kupanga magazi akuphatikizapo. Inapezeka mu August 2017.