CHOP ndi dzina lophatikizidwa la kuphatikiza mankhwala osiyanasiyana. CHOP ndi imodzi mwa mankhwala omwe amagwiritsidwa ntchito kwa omwe si a Hodgkin lymphoma, kapena NHL . CHOP imagwiritsidwa ntchito pa mitundu yamba ya nkhanza komanso ya NHL . Amakhala ndi mankhwala anayi osiyanasiyana: cyclophosphamide (Cytoxan), doxorubicin (Adriamycin), vincristine (Oncovin) ndi prednisone.
CHOP imagwirizananso ndi rituximab mu R-CHOP regimen.
Mankhwala atatu oyambirira a mankhwala a CHOP chemotherapy regimen amaperekedwa ngati jekeseni kapena kutsekemera kwa mitsempha tsiku limodzi, pamene prednisone amatengedwa ngati mapiritsi masiku asanu. Kawirikawiri, regimen yomwe imadziwika kuti R-CHOP imaperekedwa mwatsatanetsatane masabata atatu patadutsa milungu isanu ndi umodzi.
Mankhwalawa amaperekedwa mu CHOP kumenyana ndi maselo a khansa m'njira zosiyanasiyana. Pamene cyclophosphamide imagwiritsidwa ntchito monga mankhwala opatsirana khansa ku CHOP, zimagwira ntchito pochepetsa kapena kuchepetsa kukula kwa maselo a khansa m'thupi lanu. Zitha kuwonongeka chifukwa zimakhudza kwambiri kugawanika maselo m'thupi lomwe liri ndi thanzi labwino, monga lomwe limapangitsa tsitsi ndi ziwalo za m'matumbo-kutaya tsitsi ndi zizindikiro za m'mimba zimakhala zovuta.
Doxorubicin ali mu kalasi ya mankhwala otchedwa anthracyclines, ndipo imathandizanso pochepetsa kapena kuchepetsa kukula kwa maselo a khansa.
Vincristine amagwira ntchito pofuna kuteteza maselo a khansa kuti aziphatikizana, mbali imodzi mwa kuyambitsa kuwongolera kwa maipi omwe maselo a maselo amagwiritsira ntchito kupatukana ndi kugawa. Maselo a khansa ali pachiopsezo chotchedwa chemotherapy kuposa maselo achibadwa, koma chemotherapy imakhalanso ndi zotsatira pa maselo achibadwa, zomwe zimabweretsa mbiri yodalirika ya mbiri.
Mafupa Amayanjanitsidwa ndi CHOP + Rituximab
Cyclophosphamide, doxorubicin, vincristine, ndi prednisone (CHOP), akhala akugwiritsidwa ntchito kwambiri kwa zaka zambiri kwa odwala omwe ali ndi mliri waukulu wa B-cell lymphoma (DLBCL). Ambiri mwa odwala omwe ali ndi DLBCL akhoza kuchiritsidwa ndi muyezo wa rituximab + cyclophosphamide, doxorubicin, vincristine, ndi prednisone (R-CHOP). Komabe, zotsatira si zabwino kwa iwo omwe sachita bwino pa regimen.
CHOP chemotherapy imagwiritsidwa ntchito pa mitundu yambiri ya mitundu yambiri yamageremusi osalimba a Hodgkin, kuphatikizapo angioimmunoblastic T-cell Lymphoma, ndi pulogalamu ya T-cell lymphoma. Pulogalamu ya R-CHOP yakhala yoyenera kuti athetse nkhanza, Stage I ndi Contiguous Stage II Adult NHL ndi NHL yamphamvu, yosagwirizana ndi Stage II / III / IV wamkulu.
Kusamalira ndi Kuchenjeza
Nthawi zambiri Adriamycin amaperekedwa poyamba chifukwa zingakwiyitse mitsempha yanu. Ndikofunika kuti muuze namwino wopatsirana ngati mumamva kutentha kapena ululu pa tsamba lolowetsamo . Pa tsiku lomwelo, mudzapatsidwa mankhwala awiri otsatira, Cytoxan ndi Vincristine.
Kliniki ikhoza kukulimbikitsani kuti mutenge dalaivala kuti abwere kunyumba kwanu mutatha kuchipatala. Mukhoza kuona kusintha kwa mtundu wa mkodzo wanu kuchokera ku mtundu wofiira wa Adriamycin kwa masiku angapo pambuyo pa chithandizo.
Zotsatira Zogwirizana
- Kutayika tsitsi: Mudzasowa tsitsi lonse, kuphatikiza tsitsi lanu pamutu panu, nsidze, eyelashes, ndi tsitsi lanu. Kawirikawiri, izi zimayambira masabata awiri kapena atatu mutatha kuchiza, koma ndizakhalitsa ndipo tsitsi lanu liyenera kubwerera pambuyo chithandizo.
- Nthenda ndi kusanza ndizofala, kuchokera pakangotha chithandizo pakapita masiku atatu chithandizo.
- Kutenga kumakhala kofala chifukwa cha vincristine komanso mankhwala ena amaperekedwa kawirikawiri chifukwa cha kunyowa ndi kupweteka.
- Zilonda zam'mimba zikhoza kuonekera sabata imodzi mpaka masabata awiri mutatha kuchiza.
- Nkhani zokhudzana ndi chithandizo: Amayi nthawi zambiri amasokonezeka chifukwa cha kusamba kwawo ndipo amatha kulowa msinkhu kosatha. Amuna akhoza kusiya kubala umuna, kuchepetsa kubereka. Zinthuzi zikhoza kukhala zamuyaya, choncho muyenera kukambirana za chithandizo chamankhwala ndi dokotala musanayambe kumwa mankhwala. Kumbali ina, musaganize kuti simudzakhala osowa panthawi ya chithandizo, gwiritsani ntchito njira zothandizira kulera kuti muteteze mimba.
- Mutha kukhala ndi kachilombo ka HIV pa nthawi ya chithandizo cha CHOP monga momwe mungachepetsere maselo oyera a magazi ndi maselo ofiira. Ndibwino kupewa kucheza ndi anthu omwe amazizira kapena chimfine komanso kusamba m'manja nthawi zambiri kuti asatenge kachilombo kapena matenda.
- Prednisone ndi steroid ndipo imakhala ndi zotsatira zambiri, kuphatikizapo kusinthasintha, kulemera, ndi kutupa.
> Zotsatira:
> Sehn LH, Gascoyne RD. Kufalitsa kwambiri B-cell lymphoma: kukulitsa zotsatira pambali ya kugonana kwachilengedwe ndi biologic. Magazi. 2015; 125 (1): 22-32.
> Zotsatira Zotheka za Cyclophosphamide, Doxorubicin, Vincristine, ndi Prednisone (CHOP), National Cancer Institute, November 27, 2013.
> Kuchuluka kwa anthu osakhala a Hodgkin Lymphoma Treatment-kwa akatswiri azaumoyo (PDQ®), National Cancer Institute, pa January 15, 2016.