The chiphunzitso cha ukalamba chimatanthawuza kuti kupweteka kwa umunthu ndi mtundu wofatsa komanso wamba wachitetezo chodziwika bwino cha nthawi yaitali. Mwachidule, chiphunzitsochi chimati kuwonjezereka kwa ukalamba, njira zovuta kwambiri, zimayendetsedwa ndi chitetezo cha mthupi . Kuchita kukalamba ndi chinthu chovuta kumvetsa ndipo sichimvetsetsedwa bwino m'magulu azachipatala ndi sayansi.
Pamene tikudziŵika bwino ndi ndondomeko yokhayo, sitinadziwepo chifukwa chachikulu chomwe chimayambitsa ukalamba.
Zomwe Zimayambira pa Immunological Theory of Aging
Monga anthu a zaka, timakhala ndi kusintha kwakukulu kuntchito zathu zonse, kuphatikizapo chitetezo cha thupi komanso chitetezo cha mthupi. Akatswiri azachipatala atsimikizira kuti chitetezo cha m'thupi chimachepadi ndi zaka, zomwe zimathandiza kuti anthu ambiri azitha kudwala matenda omwe amayamba chifukwa cha matenda monga chimfine kapena chimfine kuti matenda aakulu omwe amabwera chifukwa cha kutupa. Ngakhale kuti chiwerengerochi chikusonyeza kuti kusintha kwa chitetezo cha mthupi kumagwira ntchito okalamba kungakhale chizindikiro cha ukalamba, otsutsa malingaliro okhudzana ndi matenda a ukalamba omwe amachititsa kuti chibwenzicho chisinthe. Otsutsawa amakhulupirira kuti zizindikiro zathu zokhudzana ndi ukalamba monga matenda aakulu zimayamba chifukwa cha kusintha kwa chitetezo cha mthupi.
Mmene Matenda autetezera Oteteza Akutha
Ambiri amadziwika kuti mawonekedwe a chitetezo cha m'thupi omwe amawoneka kuti akuphatikiza ndi ukalamba angakhudze moyo wa munthu. Chitetezo cha mthupi ndi chofunika kuti thupi lathu likhale labwino. Sikuti imatiteteza ku mavairasi ndi mabakiteriya, imathandizanso kudziwa ndi kuchotsa khansa ndi poizoni.
Pamene tikukalamba, kuthekera kwa zinthu izi kumayambitsa kuwonongeka m'matupi athu kumawonjezeka.
Koma zomwe sizikudziwika ndi zomwe zimachititsa kusintha kumeneku ku chitetezo cha mthupi komanso mmene zimakhalira ndi kupita patsogolo. Pali deta yamphamvu ya anthu yomwe imasonyeza kuti kuwonongeka kwa chitetezo cha m'thupi chokalamba, mwina mbali, kumayambitsa ndi / kapena kufotokoza mbali zina za zinthu zodziwika bwino za ukalamba.
Mmene Kusintha kwa Mthupi Kumasinthira Kungakhudzire Thupi
Kuwonjezera pa kukhala pafupi ndi mavairasi wamba ndi matenda a bakiteriya, mawonekedwe a chitetezo cha mthupi amasintha kwambiri.
Tikudziwa kuti pamene tikukalamba, chiwerengero cha maselo ofunika kwambiri pa chitetezo cha mthupi chimachepetsa ndipo sichitha kuchepa. Tikudziwanso kuti kuyambira zaka 20 zokha, thymus (yomwe ili m'dera la ubongo womwe umayambitsa maselo ena a chitetezo cha thupi) imayamba kuchepa. Koma pankhani yokhudzana ndi matenda a ukalamba, ena mwa sayansi ya zachipatala amanena kuti kuwonjezeka kwa maselo aumunthu kumakhala kovuta kwambiri. Nthanoyi imanena kuti kuwonjezeka kwa mitundu yosiyanasiyana kapena kusintha kwa maselo mu ukalamba kumapeto kumadzetsa kulephera kuzindikira kwa maselo ndi kuwonongeka kwa ziwalo zina za thupi, zomwe pamapeto pake zimayambitsa zofanana ndi zomwe zimachitika ngati kutupa kosatha.
Masiku ano, kutentha kwakukulu kumakhulupirira kuti kumapangitsa kuti matenda aakulu omwe amatha kudwala ndi khansa apite ku Alzheimer .
The Science of Aging
Maganizo a umoyo wa ukalamba ndi lingaliro limodzi loyesera kufotokoza chifukwa chake ndi momwe timakalamba. Ngakhale kuti ndizodzikweza, zimagwira ntchito ndi zovuta kwambiri (ukalamba ndi chitetezo) zomwe sitimvetsetsa.
Zotsatira:
Kukalamba Pansi pa Microscope; National Institutes of Health, National Institute of Aging.
Franceschi, C., ndi J. Campisi. "Kupweteka Kwambiri Kwambiri (Inflammaging) ndi Mphamvu Yake Yopereka kwa Matenda Omwe Akumwalira." The Journals of Gerontology Series A: Sayansi Yachilengedwe ndi Sayansi ya Zamankhwala 69.Suppl 1 (2014).
Fulop, T., JM Witkowski, G. Pawelec, C. Alan, ndi A. Larbi. "Pamaganizo a Immunological of Aging." Nkhani Zachidule Zokhudza Gerontology 39 (2014): 163-76.
Walford, Roy L. "The Immunologic Theory of Aging." Katswiri wa Gerontolo 4.4 (1964): 195-97.