Zofufuza Pezani Kogwirizana Kowoneka Pakati pa Statins ndi Inflammation
Maphunziro apeza zotsatira zopindulitsa za maimfa , kuphatikizapo mgwirizano pakati pa malemba ndi kutupa .
Kodi kutupa ndi chiyani?
Kutupa ndi gawo la momwe thupi limayankhira povulazidwa kapena matenda. Mukapeza chovulaza chaching'ono (kutayidwa kapena kudula), dera lozungulira ilo limabwereranso ndipo limatuluka pang'ono. Izi ndi zizindikiro za kutupa kwa thupi, zizindikiro za thupi lomwe limagwiritsidwa ntchito powonongeka.
Ndi gawo lachilengedwe la machiritso. Koma nthawi zonse sizothandiza.
Kutupa kumachitika pamene chitetezo cha mthupi chimatumiza ku maselo apadera a magazi oyera ku malo owonongeka. Maselo amenewa amathandiza kuthana ndi matenda aliwonse ndi kuyeretsa maselo omwe anasiyidwa mmbuyo. Ndondomeko yomweyi yomwe imachitika ndi kudula, kuvulaza kapena kupweteka kumakhalanso ndi kuvulala kwa minofu kapena mitsempha ya mtima.
Udindo wa LDL Cholesterol mu Kutupa
Mofananamo, thupi limatumiza magulu amphamvu a chitetezo cha chitetezo cha mthupi kumadera otentha kwambiri - omwe ndi mapale omwe amapezeka ndi cholesterol ( LDL ) mumadzimadzi. Mwamwayi, pamene macrophage atenga zipilalazi, amatha kukhala ndi cholesterol ndipo amatha kuwonjezera pa chipikacho. Ngakhale kuti cholinga chake ndi kulimbana ndi chipikacho, kutulutsa kotupa kumapangitsa kuti plaque ikhale yosasunthika komanso yowonongeka, ndipo izi zingayambitse matenda a mtima kapena kupwetekedwa mtima.
Kuwonjezera pamenepo, kutupa m'mitima ndi mitsempha imayambitsa makoma a magazi kuti akhale "ndodo" ndipo amatha kukopera maselo ena owonjezera a magazi ndi cholesterol, zomwe zimapanga chikhomo, kapena amatha kuyikapo ndalama zomwe zimakhalapo kale. Pamapeto pake, njirayi ingalepheretse kutaya kwa magazi ndi mpweya.
Ngati mitsempha yosokonezeka imapereka mtima kapena ubongo, kachiwiri, zotsatira zake zikhoza kukhala matenda a mtima kapena kupwetekedwa .
C-Reactive Protein mu Kutupa
Pamene kutupa kulipo kulikonse m'thupi, mapuloteni enieni amamasulidwa m'magazi omwe angathe kuyeza pogwiritsa ntchito mayeso a magazi. Mayesero ena, monga erythrocyte sedimentation mlingo (ESR, kapena "sed rate") ndizoyeso zonse za kutupa. Puloteni wothandizira kwambiri (CRP) ndiyeso yowonjezera kapena matenda m'thupi. Mipikisano ya CRP pamwamba pa 10 mg / L ndi chizindikiro chakuti kutupa kulipo kwinakwake m'thupi. Komabe, pamene CRP imakwera mofatsa, pakati pa 1 mg / L mpaka 3 mg / L, yakhala ikukhudzidwa ndi mavuto ndi mtima wa mitsempha, yomwe ndi mtima ndi mitsempha ya magazi.
Ngakhale kuti ma CRP apamwamba ndi mbali ya chilengedwe cha thupi lanu pakadutsa mavuto, iwo ndi nkhani zoipa. Amatha kufotokoza za matenda a mtima mwa anthu omwe sanakhale nawo kale. Pankhani ya odwala omwe amachititsa njira zina za mtima - kuphatikizapo angioplasty , malo oikapo miyala, ndi mitsempha yowonongeka - ndi omwe ali ndi vuto la mtima wamtima-angina okhazikika kapena angina osakhazikika - ma level high CRP agwirizana chiwopsezo chowonjezereka cha matenda a mtima kapena kupwetekedwa mtima komanso mwayi wochuluka wa imfa.
Koma, kuteteza kutupa kumathandiza anthu omwe ali pangozi ya matenda a mtima. Zinthu zofunika kwambiri za matenda a mtima zimaphatikizapo kuthamanga kwa magazi , shuga , cholesterol, kusuta fodya kapena mbiri ya banja la matenda a mtima.
Kodi ma Statin amachita chiyani ndi kutupa ndi kuchepetsa miyeso ya CRP?
Statins ndi mankhwala ofunika kwambiri omwe amachepetsetsa mafuta ambiri m'thupi. Ma Statins amathandiza kupewa matenda a mtima, kupwetekedwa ndi mavuto ena okhudzana ndi cholesterol (LDL) choipa kwambiri m'magazi. Amadzichepetsa amatsitsimutsa magazi ambiri m'thupi mwawo ( HDL ). Statins amagwira ntchito poletsa mavitamini otchedwa HMG-CoA kuchepetsa zomwe zimafunika kuti apange cholesterol choipa kuchokera ku mafuta odzaza .
Kuwonjezera pa kuchepetsa makilogalamu oipa a cholesterol, ma statins amathandizanso kuchepetsa magulu a magazi a CRP. Ngakhale kuti cholesterol-choteteza chitetezo chimamveka bwino, njira zothetsera CRP ndi kutupa sizidziwika bwino. Asayansi amakhulupirira kuti ma statins amaletsa mapuloteni ndi maselo a chitetezo m'thupi omwe amamasulidwa monga mbali ya thupi yotentha. Kutsika kwa mapuloteni awa mosamala kumathandiza kuti kutupa kuchitike.
Zikuwonekeranso kuti kugwiritsidwa ntchito kwa nthawi yaitali kwa zilembo kumabweretsa kuchepa pang'ono mumtima ndi zovuta zochepa. Kafukufuku wa odwala omwe akudwala angioplasty akusonyeza kuti anthu omwe amatsatira malamulowa asanakhale ndi CRP pambuyo pake ndipo sankakhala ndi matenda a mtima kapena kufa chaka chotsatira.
Kafukufuku wa odwala omwe anali ndi zikwapu za ischemic apeza kuti mu nthawi yochepa ndi kwa chaka chimodzi pambuyo pa kupwetekedwa, odwala omwe amatenga zilembo amakhala ndi ma CRP ochepa komanso zotsatira zabwino. Zopindulitsa izi zinaphatikizapo zofooka zochepa za m'mimba, monga kulankhula ndi mavuto. Panalinso chiwerengero chochepa cha imfa m'chaka chotsatira. Kuonjezera apo, maimidwe amachepetsa chiopsezo cha poizoni kwa anthu omwe akhala ndi chochitika chachikulu, monga matenda a mtima.
Monga momwe kukhalapo kwa CRP m'magazi kungawonetsere mavuto a mtima, kuchepetsa ma CRP kumachepetsa kuopsa kwa mtima wa mtima kapena zochitika zina zamtima, kuphatikizapo kupwetekedwa mtima. Ngakhale kuti ndondomeko yeniyeniyi idakalipobe, asayansi apanga mgwirizano wooneka pakati pa malemba ndi kuchepetsa ma CRP. Komanso, kafukufuku amasonyeza kuti kupindula kwakukulu pa kutenga zilembo ndi anthu omwe ayambira ndi ma CRP; Madalitsowa ndi ochuluka koposa momwe angayesere ndi zotsatira za ma kolesterolini okha.
Ndikofunika kukumbukira kuti kuchepetsa ma CRP ndi statins sikwanira ndekha kuteteza mtima wamtima. Ngakhale kuti m'madera otsika a CRP ali opindulitsa, matenda onse a mtima - monga matenda a shuga, kuthamanga kwa magazi , kusuta, kunenepa kwambiri / kapena cholesterol chokwanira - amachititsa matenda a mtima ndipo amachititsa kuti munthu akhale ndi matenda a mtima kapena kupwetekedwa mtima. Njira yabwino yopewera zochitikazi ndizochita masewero olimbitsa thupi, ndizitsatira mankhwala oyenera monga momwe akulimbikitsira ndi wothandizira zaumoyo kuti athe kuchepetsa zoopsa zanu monga momwe zingathere.
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