Ezetimibe ndi mankhwala omwe amachepetsa mafuta m'thupi . Yakhala FDA yovomerezeka kuyambira 2002, ndipo imagulitsidwa ngati mankhwala okhaokha (Zeta) kuphatikizapo simvastatin ( statin mankhwala) monga Vytorin. Komabe, ezetimibe wakhala akutsutsana kwambiri kuyambira pachiyambi chake, ndipo akatswiri akutsutsabe za malo ake oyenerera pochiza matenda a lipid.
Ezetimibe
Ezetimibe amagwira ntchito poletsa kutsekemera kwa mafuta m'thupi m'matumbo.
Kawirikawiri, cholesterol yotengedwa m'mimba imatengedwa ndi ma chylomicrons ku chiwindi, kumene imagwiritsidwa ntchito pazinthu zingapo zofunika kwambiri. Pamene kuchuluka kwa cholesterol kumachepetsedwa ndi ezetimibe, chiwindi chiyenera kutenga cholesterol mwa kuchotsa lipoproteins m'magazi. Motero, cholesterol ya magazi imachepetsedwa.
Kawirikawiri, ezetimibe mwina palokha kapena kuphatikiza ndi statin imachepetsa kuchuluka kwa LDL cholesterol m'magazi ndi pafupifupi 15%.
Zotsatira Zoipa za Ezetimibe
Kawirikawiri, ezetimibe amavomerezedwa bwino. Mphuno, kutsegula m'mimba, ndi kusintha kwake kumatha kuchitika. Ngakhale kuti matenda a myopathy (misampha yovulaza) imakhala ndi ezetimibe, ofanana ndi myopathy yomwe imapezeka ndi statins , vuto la vutoli likuwoneka kuti ndi lochepa kwambiri kusiyana ndi zilembo. Ndipotu, ezetimibe ikhoza kuwonjezeredwa ndi chiwerengero cha dozi chochepa kuti athetsere cholesterol chokha popanda kuchepetsa vutoli lomwe nthawi zina limawoneka ndi zizindikiro zapamwamba.
Kutsutsana ndi Ezetimibe
Pamene ezetimibe inavomerezedwa koyamba, idagulitsidwa monga Vytorin (ezetimibe ndi simvastatin), ndipo malonda anali ovuta. Mukhoza kukumbukira zamalonda nthawi zambiri poyerekeza ndi azakhali anu okoma, a rotund Suzie kupita ku chidutswa chachikulu cha mphika wa sitiroberi. Ameneyo anali Vytorin.
Zikuoneka kuti, pamene malondawa anali kuthamanga ndipo pamene Merck anali kugulitsa Vytorin mabiliyoni ambiri, bukuli linachedwetsedwa (mosakayikira, ena amati) pa mayesero ovomerezedwa ndi Merck omwe amatchedwa ENHANCE. ENHANCE cholinga chake chinali kutsimikizira kuti Vytorin analimbikitsa atherosclerotic plaques kuposa simvastatin yekha. Zotsatirazo zitatulutsidwa m'chaka cha 2008, adaphunzira kuti anthu omwe amachitira ndi Vytorin anachita zoipa kwambiri kuposa omwe amalandira simvastatin okha.
Chifukwa cha zotsatira zoipa izi (komanso kuti ambiri amaona kuti kuchedwa kwa kufotokozera izi kumawoneka osayenera), malonda a ezetimibe. Ndipo malondawa anawonongeka kwathunthu.
Chidwi cha ezetimibe chafalikira kuyambira mu 2014, pamene zotsatira za PRPR -VE IT zinayambitsidwa. Mu mayeserowa, odwala omwe ali ndi matenda oopsa (ACS) adasankhidwa kuti alandire Vytorin kapena simvastatin okha. Pambuyo pa zaka zisanu ndi chimodzi, odwala omwe amalandira Vytorin adasintha bwino kwambiri zotsatira zachipatala (zochepa zowerengera za ACS, ndi zochepa zofunikira za opaleshoni zochepa kapena zochepa), koma panalibe kusiyana pakati pa kupulumuka.
Gulu laling'ono la kafukufuku wa ZINTHU ZOCHITIKA - Zomwezo zinapangitsa kuti phindu lonse lopezeka m'gulu la Vytorin liwerengedwe ndi odwala matenda a shuga.
Kwa anthu omwe alibe shuga, palibe phindu loonjezera ezetimibe.
Kodi Ezetimibe Iyenera Kugwiritsidwa Ntchito Liti?
Kawirikawiri, ntchito ya ezetimibe iyenera kukhala yoperewera. Malangizo omwe adatulutsidwa mu 2013 pa cholesterol samalimbikitsa kupereka mankhwala kwa mtundu uliwonse wa cholesterol. M'malo mwake, amaganizira zogwiritsa ntchito mankhwala osokoneza bongo kapena ayi. Kotero "mankhwala ochepa" omwe amaletsa mafuta m'thupi monga ezetimibe ali ndi malo ochepa kwambiri pansi paziganizozi. Nthaŵi zina madokotala amapereka malemba a ezetimibe ndi a dose otsika kwambiri kwa anthu omwe ayenera kukhala pazithunzi zapamwamba, koma sangathe kulekerera mlingo waukulu.
Komanso, ezetimibe nthawi zina amagwiritsidwa ntchito mmalo mwa zilembo kwa odwala omwe sangathe kutenga statins pa mlingo uliwonse.
Pomalizira, pogwiritsa ntchito IMPROVE-IT phunziro, akatswiri a cardiologists amaona kuti n'zomveka kugwiritsa ntchito ezetimibe kuphatikizapo odwala matenda a shuga amene ali ndi ACS yaposachedwapa.
Kuwonjezera pa zochitika zochepa za matendawa, pakadali pano palibe chifukwa chokwanira ezetimibe.
> Zotsatira:
> Cannon CP, Blazing MA, Giugliano RP, et al. Ezetimibe Wowonjezeredwa ku Statin Therapy pambuyo pa Acute Coronary Syndromes. N Engl J Med 2015; 372: 2387.
> Kastelein JJ, Akdim F, Stroes ES ndi al .; Ofufuza: ANTHU OYENERA KUKHALA OYENERA KUTSATIRA KUKHALA OYENERA KUKHALA MWA EEZEEBE KUKHALA OCHOKHUDZANA NDI ACHINYAMATA. N. Engl. J. Med. 358, 1431-1443 (2008).