Kodi Xopenex ndi bwino kuposa Albuterol?
Xopenex (levalbuterol) ndi mankhwala osakaniza kuti athe kuchiritsidwa ndi zizindikiro zazikulu za mphumu , kuphatikizapo kutsokomola, kupuma, kupuma pang'ono ndi chifuwa. Xopenex amagwira ntchito mwa kutulutsa minofu yosalala m'mapapo, nthawi zambiri mumatha maminiti owerengeka kumwa mankhwala. Xopenex imapezeka zonse monga inhaler komanso mawonekedwe kudzera kudzera nebulizer makina.
Xopenex ndi yogwira ntchito ya albuterol (yotchedwa R-albuterol kapena levalbuterol). Mankhwalawa amapezeka ngati magalasi osiyana-siyana (otchedwa kusakanikirana osakaniza), ndipo imodzi yokha ya mankhwalawa ndi mankhwala othandiza. Fomu yopanda ntchito (yotchedwa S-albuterol kapena dextroalbuterol) sichitha kanthu kupatula kuti "imalowa" mwa mawonekedwe ogwira ntchito ndipo ingapangitsebe zotsatirapo. Ichi chinali cholinga chomwe Xopenex chinakhazikitsidwira - kukonza ntchito ya albuterol pamene kuchepetsa zotsatira zake.
Kodi Xopenex Ndi Yabwino kuposa Albuterol ya Asthma?
Izo sizikuwonekera bwino. Pamene Xopenex inayamba kukonzedwa, maphunziro a zinyama adanena kuti S-albuterol inachititsa kutupa m'mapapu, zomwe zingawononge mphumu. Ankaganiziranso kuti monga albuterol yochulukirapo (chisakanizo cha R ndi S-albuterol isomers) chinatengedwa, S-albuterol isomerom ingapezeke m'mapapu ndipo imapangitsa kuti mitsempha yosochera iwonongeke m'mapapo, ndipo izi zimawopsyeza zizindikiro za mphumu. .
Choncho Xopenex amayenera kugwira bwino ntchito pochiza matenda a mphumu kuposa albuterol.
Maphunziro oyambirira adasonyeza kuti Xopenex anali bwino pochiza mphumu kusiyana ndi albuterol, popeza kuti Xopenex ochepa ankafunika kuti athetse mphamvu za asthma kusiyana ndi albuterol yofanana. Popeza Xopenex ndi theka yogwira ntchito ya albuterol, wina angayembekezere kuti theka la doko la Xopenex lidzakhala lofanana ndi kawiri ka dose ya albuterol; Komabe, maphunzirowa adawonetsa kuti gawo limodzi mwa magawo anayi a mlingo wa albuterol ankafunika kuti akwaniritse zotsatira zomwezo pogwiritsa ntchito Xopenex.
Izi zinkaganiziridwa kuti ndizo chifukwa cha kusowa kwa S-albuterol mpikisano mu Xopenex, yomwe ikugwira ntchito motsutsana ndi chiwerengero cha R-albuterol.
Zotsatira zatsopano za Xopenex, komabe, komanso mwachidule za deta zonse zomwe zilipo, zikusonyeza kuti Xopenex sangachite bwino pochiza mphumu kuposa momwe tingayembekezere. Mliri wa Xopenex wofunikira kuti upeze zotsatira zofanana za kuchiza mphumu kumawoneka ngati pafupifupi hafu, zomwe ndi zomwe zimayembekezeka chifukwa zili ndi chiwombankhanga (R-albuterol). S-albuterol isomerom ikuwonekera kukhala yowonongeka, kutanthauza kuti sikuchita kapena kutsutsana ndi zizindikiro za mphumu.
Kodi Xopenex Ali ndi Zotsatira Zochepa kuposa Albuterol?
Albuterol imadziwika kuti imayambitsa zotsatira zina, kuphatikizapo kuthamanga kwa minofu, kuthamangirira, palpitations ndi kuwonjezeka kwa mtima. Maphunziro oyambirira a Xopenex adanena kuti popeza mankhwala ochepa kwambiri anali oyenerera kuti athandizidwe monga albuterol, zotsatirapo zochepa zikanachitika. Kuwonjezera apo, poyamba poyamba ankaganiza kuti S-albuterol isomerom kwenikweni ndiyo yomwe imayambitsa zotsatira zambiri za albuterol, choncho Xopenex, yomwe ilibe S-albuterol, ingawononge zotsatira zochepa.
Kafukufuku waposachedwapa amasonyeza kuti zotsatira za Xopenex zimakhala zofanana ndi albuterol chifukwa kwenikweni ndi R-albuterol isomerom yomwe imayambitsa zotsatira za albuterol.
S-albuterol isomerom is inert, kutanthauza kuti sichimayambitsa zotsatirapo. Phukusi la Xopenex limanena kuti mlingo wa zotsatirazi zapamwambazi ndi zofanana ndi Xopenex ndi albuterol.
Phunzirani momwe mungagwiritsire ntchito ndi kuyeretsa Xopenex inhaler .
Zotsatira:
Fupi la Xopenex [PDF]. Sepracor corporation. Inapezeka pa January 13, 2011.
Ahrens R, Weinberger M. Levalbuterol ndi Racemic Albuterol: Kodi Pali Kusiyanasiyana kwa Matenda? J Zachilombo Zamtundu wa Immunol. 2001; 108: 681-4.
Milgrom H, Skoner DP, Bensch G, et al. Levalbuterol ya ana aang'ono omwe ali ndi chifuwa chachikulu: Chitetezo ndi Kuchita bwino poyerekeza ndi Placebo ndi Racemic Albuterol. J Zachilombo Zamtundu wa Immunol. 2001; 108: 938-45.
Lötvall J, Palmqvist M, Arvidsson P, ndi al. Chiwerengero cha mankhwala a R-Albuterol n'chofanana ndi cha RS-Albuterol mu Odwala a Asthmatic. J Zachilombo Zamtundu wa Immunol. 2001; 108: 681-4.