Kodi Mbalameyi Imatha Kuthana ndi Khansa?
Diindolylmethane ndi chilengedwe chachilengedwe pamene thupi limaphwanya indole-3-carbinol, kamodzi kamene kamapezeka m'mitengo yotchedwa broccoli ndi kale. Zopezeka mu mawonekedwe othandizira, diindolylmethane akuti amapereka madalitso ochuluka a thanzi.
Chifukwa Chimene Anthu Amazitenga Izo
Diindolylmethane imatulutsa kusintha kwa matenda a estrogen, njira yomwe imaganiziridwa kuti iwononge chitukuko cha khansa yodalirika yotchedwa hormone monga khansa ya m'mawere.
Otsutsa akuti kudya diindolylmethane kungakuthandizeni kuonjezera chitetezo chanu pa mitundu ingapo ya khansa, komanso kulimbikitsanso kutaya mphamvu ndi kuthandizira kuchepa.
Ubwino
Pakadali pano, kafukufuku wokhudzana ndi thanzi la diindolylmethane alibe malire. Pofufuza kafukufuku, akatswiri ena asayansi apeza kuti diindolylmethane ikhoza kuwonetsa thupi kuti liwonongeke ndi estrogen.
Ngakhale kuti kuganiza kuti kusintha kwa maselo a estrogen kungathandize kutetezera ku khansa yodalirika (monga khansa ya m'mawere), palibe kufufuza kokwanira kudziwa ngati diindolylmethane ingathandize kuthana ndi khansa.
Pano pali mawonekedwe ena ofunika kuchokera ku maphunziro omwe alipo:
1) Khansa ya m'mawere
Ngakhale kuti maphunziro ena a ma laboratories amasonyeza kuti diindolylmethane ingathandize kuchepetsa kukula kwa maselo a kansa ya m'mawere, pakhala pali maphunziro ochepa ochipatala.
Mu kafukufuku wochepa wa 2004 omwe anafalitsidwa mu Nutrition ndi Cancer , ofufuza adapeza kuti kutenga diindolylmethane zowonjezereka kumayambitsa kusintha kwa maselo a estrogen.
Kafukufukuyu anaphatikizapo amayi 19 omwe amapezeka m'mimba mwa amayi omwe ali ndi mbiri ya khansa ya m'mawere oyambirira.
Phunziro la 2015 lofalitsidwa mu Familial Cancer linagwiritsa ntchito 300 mg patsiku la diindolylmethane kwa masabata anayi kapena asanu ndi mmodzi mwa amayi khumi ndi asanu omwe ali ndi kusintha kwa BRCA1. Chiŵerengero cha urinary estrogen (chilengedwe chosiyana kwambiri chokhudzana ndi kukula kwa khansa ya m'mawere) sichinasinthe kwambiri pambuyo poonjezera.
2) Khansa ya m'mimba
Ngakhale kuti deta ina yanena kuti kutenga mavitamini a diindolylmethane kungachepetse chitukuko cha khansara ya chiberekero, phunziro la 2012 lofalitsidwa mu British Journal la Cancer linalephera kusonyeza phindu lililonse. Phunziroli linaphatikizapo amayi 551 omwe anali atangoyamba kumene, omwe anali ochepa kwambiri m'maselo achiberekero. Kwa miyezi isanu ndi umodzi, ophunzira adatenga zowonjezereka za diindolylmethane kapena placebo tsiku ndi tsiku. Diindolylmethane zowonjezera mavitamini alephera kuthandizidwa kwambiri pa selo lachiberekero kusintha kapena kukhalapo kwa HPV.
3) Njira Zina za Khansa
Zofufuza zoyambirira kuchokera ku kafukufuku wamagetsi ndi kafukufuku wanyama zimasonyeza kuti diindolylmethane ikhoza kuteteza chitetezo cha prostate , khansara ya ovari, ndi khansa yamtundu . Komabe, chifukwa cha kusowa kafukufuku, ndiposachedwa kwambiri kuti adziwe ngati diindolylmethane ingathandize kuthana ndi mitundu iyi ya khansara mwa anthu.
4) Kutaya Kwambiri
Ngakhale kuti diindolylmethane zowonjezera nthawi zina zimakhala ngati zowonongeka zochepa, palibe umboni wa sayansi wotsimikizira kuti kutenga diindolylmethane kumalimbikitsa kulemera.
Zotsatira
Diindolylmethane imapangidwa pamene thupi limapanga katemera-3-carbinol, komiti yomwe imapezeka masamba awa:
- Burokoli
- Kuphulika kwa Brussel
- Kabichi
- Kolifulawa
- Collard amadyera
- Kale
- Mbeu ya mpiru imabzala
- Watercress
Diindolylmethane imapezedwanso mu mawonekedwe othandizira, ogulitsidwa m'masitolo ogulitsa zachilengedwe ndi malo ogulitsa zakudya zowonjezera zakudya.
Zotsatira Zowonongeka Zotheka
Pakalipano, podziwika pang'ono za chitetezo chogwiritsa ntchito diindolylmethane zowonjezereka nthawi zonse kapena nthawi yayitali.
Chifukwa cha matenda a diindolylmethane omwe angakhudze maselo a estrogen, pali vuto linalake kuti kutenga mavitamini a diindolylmethane kungachititse kuti mahomoni asamangidwe (kuphatikizapo khansa yodalirika, endometriosis , ndi uterine fibroids ).
Malingana ndi lipoti lina, mayi wina wathanzi amafotokoza kuti pakati pa serous chorioretinopathy (vuto limene limayambitsa kuwonetsa kwa maso) pambuyo pa kudya tsiku ndi tsiku kwa diindolylmethane kwa miyezi iwiri.
Pambuyo posiya kuwonjezereka, zizindikiro zake zimatha pambuyo pa masabata eyiti. Khungu limathamanga ndi eosinophilia (zowonongeka za majeremusi omwe amapezeka kawirikawiri chifukwa cha mtundu wina wa mankhwala osokoneza bongo kapena mankhwala osokoneza bongo) adanenedwa potsatira kugwiritsa ntchito diindolylmethane. Zilonda za minofu ndi zamphongo, makamaka m'chiuno ndi mawondo, zafotokozedwa.
Chifukwa cha nkhawa, ndikofunika kupeza uphungu asanayambe kugwiritsa ntchito mankhwala owonjezera a diindolylmethane. Azimayi omwe ali ndi pakati kapena akuyamwitsa sayenera kutenga zowonjezereka za diindolylmethane. Komanso, anthu amene akuchiritsidwa ndi khansa sayenera kumwa.
Mungapeze malangizo othandizira kugwiritsa ntchito zowonjezeretsa apa , koma ndizofunikira kuzindikira kuti kudziletsa nokha ndi diindolylmethane ndi kupeŵa kapena kuchedwetsa chisamaliro choyenera kungakhale ndi zotsatira zoopsa.
Mtsinje
Chifukwa cha kusowa chithandizo cha sayansi, ndiposachedwa kwambiri kuti atsimikizire kuti diindolylmethane zowonjezera mavitamini monga chithandizo choyenera cha matenda alionse.
Komabe, kuwonjezera miyezo yanu ya diindolylmethane mwa masamba a cruciferous a indole-3-carbinol mu zakudya zanu zingakuthandizeni kuti mukhale ndi thanzi labwino. Masamba a Cruciferous ali ndi zinthu zambiri zolimbikitsa thanzi, kuphatikizapo antioxidants.
Zotsatira
Castañon A, Tristram A, Mesher D, et al. Zotsatira za diindolylmethane supplementation pa zochepa zapamwamba za kervical cytological odalirika: kawiri-wakhungu, randomized, woyesedwa kuyesedwa. Br J Cancer. 2012 Jan 3; 106 (1): 45-52. lembani: 10.1038 / bjc.2011.496.
Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF. Phunziro la oyendetsa: zotsatira za 3,3'-diindolylmethane zowonjezera mavitamini a mitsempha ya m'mitsempha mumayi omwe ali ndi mbiri ya mmaopa omwe ali ndi mbiri ya khansa ya m'mawere oyambirira. Khansara ya Khansa. 2004; 50 (2): 161-7.
Nikitina D, Llacuachaqui M, Sepkovic D, et al. Zotsatira za katatu 3,3'-diindolylmethane supplementation pa 2: 16a-OHE chiŵerengero cha BRCA1 zonyamulira kusintha. Nyerere ya Fam. 2015 Jun; 14 (2): 281-6. lembani: 10.1007 / s10689-015-9783-2.
Smith S, Sepkovic D, Bradlow HL, Auborn KJ. 3,3'-Diindolylmethane ndi genistein amachepetsa zotsatira zoopsa za estrogen mu maselo a khansa ya prostate ya LNCaP ndi PC-3. J Nutriti. 2008 Dec; 138 (12): 2379-85.
Staub RE, Onisko B, Bjeldanes LF. Tsoka la 3,3'-diindolylmethane mu maselo a khansa ya m'mawere a umunthu a MCF-7. Chem Res Toxicol. 2006 Mar; 19 (3): 436-42.
Chodziwikiratu: Zomwe zili pa tsambali zimapangidwa pazinthu zophunzitsira zokha ndipo sizilowetsamo malangizo, matenda kapena chithandizo ndi dokotala wololedwa. Sichikutanthauza kubisa zonse zomwe zingatheke, kuyanjana kwa mankhwala, zochitika kapena zotsatirapo zoipa. Muyenera kupeza chithandizo chamankhwala mwamsanga pa nkhani iliyonse yathanzi ndikufunsani dokotala musanagwiritse ntchito mankhwala osakaniza kapena kusintha kwa regimen yanu.