Vitamini A mankhwala, kuphatikizapo Retinol ndi Retin-A, akhala akutchedwa "ndondomeko ya golide" yosamalidwa khungu lakalamba, kuthandiza khungu lanu kuwoneka laling'ono ndi labwino. Koma kodi izi zowonjezera zinayamba bwanji, ndipo ndi zothandiza bwanji pochizira makwinya, ndi khungu lokalamba?
Vitamini Wofunika
Kufunika kwa vitamini A ku thanzi lathu kunawonekera kumayambiriro kwa zaka za zana la makumi awiri ndi makumi awiri, pozindikira kuti ntchito yake imakhala yotheka pa kamwana kameneka.
Kuchokera nthawi imeneyo, zapezeka kuti ndizosewera kwambiri osati kumangobereka, komanso masomphenya, kukula, ndi kusiyana kwa maselo ndi kuchulukana. Chifukwa zimathandiza kupanga maselo oyera a magazi, vitamini A ndizofunika kuti chitetezo cha mthupi chitetezeke.
Vitamini A imadziwikanso ngati retinol, ndipo zotsatira zake (kaya zachilengedwe kapena zopangidwa) zimatchedwa retinoids. Chifukwa vitamini sizingapangidwe ndi thupi, zimayenera kudyetsedwa ndi chakudya - kaya kudzera mu zinyama, nsomba, chiwindi, ndi nyama, kapena zochokera ku zomera, monga zipatso zamdima ndi masamba omwe amadya mbatata, maungu, ndi tomato.
Thandizo kwa Khungu Lakula
Vuto la Vitamin A ngati khungu loletsa anthu okalamba limadabwitsa zaka za m'ma 1980 pamene ofufuza adapeza kuti tretinoin yotchedwa deriinative (dzina lake Retin-A) inathandiza kwambiri kupanga collagen popanga khungu pakagwiritsidwa ntchito pamutu pamtundu wa khungu. kutulukira kuwala kwa ultraviolet kuchokera ku dzuwa.
Pogwirizana ndi zomwe anapezazi, adokotala anafotokoza kuti mankhwalawa ndi osowa omwe odwala amakhala ndi khungu lofewa, ndipo amakhala ndi makwinya ochepa. Kenaka Tretinoin anapezeka kuti akusokoneza mavitamini omwe amagwira ntchito kugwetsa collageni pachimake cha khungu komanso kulimbikitsa kupanga collagen yatsopano.
Kuyambira nthaŵi imeneyo, retinoids adadziŵika kuti ndi "golide" wokhala ndi mankhwala okalamba, malinga ndi olemba a kafukufuku wofukufuku wa 2003 omwe analemba mu Journal of Drugs in Dermatology .
Zabwino, Zoipa ndi Osauka a Tretinoin
Tretinoin m'maganizo osiyanasiyana (kawirikawiri 0.01 - 0.1%) yafufuzidwa bwino mu kufufuza kwa nthawi yayitali komanso kwa nthawi yaitali, malinga ndi kafukufuku wochuluka wa 2006 wa Clinical Interventions in Aging .
Ngakhale kuti vitamini A yogwiritsidwa ntchito yowonjezereka, isotretinoin (dzina lachidziwitso la Accutane ), inathandizanso odwala kukhala ndi khungu lofewa, pinker, m'kamwa ndi isotretinoin ali ndi vuto lalikulu la kubala. Ngakhale kuti mapuloteni asanakhalepo m'maphunziro omwe amawopsyeza, mayankho ena amachititsa kuti amayi azikhala ndi zolepheretsa kubadwa pakhungu lawo m'miyezi itatu yoyamba ya mimba. Akazi amachenjezedwa kuti asagwiritse ntchito mankhwalawa pamene ali ndi pakati.
Ogwiritsa ntchito madandaulo akuluakulu ali ndi tretinoin ndi zotsatira zake tsopano monga retinoid dermatitis, zomwe zimaphatikizapo kufiira, kukhumudwa ndi kukula komwe kungapangitse mwamsanga kapena mkati mwa masabata angapo kuti ayambe kumwa mankhwala. Nthawi zambiri madokotala amalimbikitsa kuti ayambe kusungunuka (0.01 - 0.025%), ndi kuzigwiritsa ntchito pang'onopang'ono tsiku lililonse.
Kusintha kuchokera ku gel osakaniza mafuta ochepetsetsa kumathandizanso kuchepetsa khungu. Pokhapokha kulekerera kwakhazikika, kugwiritsa ntchito mankhwalawa tsiku lililonse ndi / kapena kugwiritsa ntchito mlingo wochulukirapo kungakhale kosamalidwa bwino.
Zosintha Zithunzi
Tretinoin imawoneka bwino kwambiri pochepetsa miyendo yabwino ya nkhope ndi makwinya, kuchepetsa kukwiya, khungu lotsekedwa, komanso kusintha mazira osagwirizana. Zitha kutenga miyezi ingapo kuti zotsatira izi ziwonekere, ndipo zotsatira zake zimadalira mzere, zomwe zikutanthauza kuti zimakhala zolimba kwambiri zimabweretsa zotsatira mwamsanga. Mwachitsanzo, pamene chiwerengero cha 0.05% chikhoza kuchepetsa kwambiri zotsatira za photodamage, kotero theka la (kapena 0.025%), koma lachiwiri lidzatenga nthawi yaitali.
Zolingalira zosakwana 0.01% sizinawonekere zothandizira khungu lakujambula.
Zina zomwe zimakhudza momwe ntchito zogwirira ntchito zimaphatikizirapo ma genetic, khalidwe la khungu, komanso kukula kwa photodamage.
Mavitamini ena a Vitamini A
Matenda a Tretinoin omwe amachititsa kukhumudwa kwa khungu komanso mtundu wake monga mankhwala (osowa mankhwala) wapangitsa kufufuza kwakukulu ndi opanga mankhwala ndi mankhwala osagwirizana. Zina mwazo ndi retinol, retinaldehyde, ndi retinyl palmitate. Retinol amatembenuzidwa kukhala tretinoin pakhungu, ngakhale kuti mndandandawo umakhala ndi 1/1000 wokha wa tretinoin (ndipo motero sungakhumudwitse) ukagwiritsidwa ntchito pamwamba.
Mavitamini ambiri ochokera ku mavitamini A opangidwa kuti agulitse okalamba pamsika msika ali ndi zoyenera - popanda kafukufuku wofalitsidwa m'magazini a maphunziro - choncho ndi kovuta kubwereza.
Pansi
Vitamini A zopangidwa ndi mankhwala otchedwa topical tretinoin zasonyezedwa kuti zichepetse makwinya, ubweya wofiira, ndi mawonekedwe osagwirizana, ngakhale (zosadabwitsa) zingayambitse kufiira ndi kukwiya m'kanthawi kochepa. Ngati mukufuna kuwayesa kuti asinthe photoaging, funsani wothandizira zaumoyo wanu kapena onani dermatologist pa mankhwala. Zakudya zamtundu wambiri zomwe zili ndi mavitamini A zowonjezera zingathandizenso khungu lakukalamba, ngakhale kuti zotsatira zake sizikhala zovuta, ndipo zimakhala zovuta kutsimikizira.
Zotsatira:
Kusintha Kwakukula Khungu. Msonkhano wa US National Institute of Health Medline. http://www.nlm.nih.gov/medlineplus/ency/article/004014.htm
Kockaert M, Neumann M. Zovuta, ndi mankhwala opangira mankhwala a khungu lakukalamba. J Mankhwala Osokoneza Bongo. 2003 Aug, 2 (4): 435-41.
Siddharth Mukherjee, Tsiku la Abhijit, Vandana Patravale, Hans Christian Korting, Alexander Roeder, ndi Günther Weindl. Retinoids pochiza khungu la khungu: mwachidule zothandiza kuchipatala ndi chitetezo. Kuthana ndi matenda a Clinic. 2006 December; 1 (4): 327-348
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699641/
Vitamini A. Maphunziro a Zigawo Za Zaumoyo Zokhudza Umoyo. http://www.nlm.nih.gov/medlineplus/druginfo/natural/964.html