Mankhwala ochepetsa kachilombo ka HIV adasunthidwa kuti asankhe Njira yoyamba ku US
Tivicay (dolutegravir) ndi mankhwala ochepetsa antiretroviral integrase inhibitor omwe amagwiritsidwa ntchito pochiza HIV. Anali wachiwiri mu kalasi ya integrase inhibitors kuti avomerezedwe ndi US Food and Drug Administration (FDA).
Tivicay anapatsidwa chilolezo cha FDA pa August 12, 2013, kuti agwiritsidwe ntchito kwa akuluakulu komanso ana a zaka 12 kapena kuposerapo omwe akulemera 88 lbs (40kg) ndipo sankachiritsidwa kale ndi inhibitor ya integrase.
(Tivicay panopa sivomerezedwa kwa ana a zaka zosapitirira khumi ngakhale kuti mayesero a Phase III akuyang'aniridwa kuti ayesetse chitetezo chake ndi mphamvu zake m'zaka zimenezo.)
Tivicay ndi kachilombo ka mankhwala osakaniza kamodzi, tsiku ndi tsiku, Triumeq , yomwe imaphatikizapo mankhwala abacavir ndi lamivudine. Triumeq inavomerezedwa ndi FDA pa August 22, 2014.
Mfundo Zowunika Kwambiri pa Zamakono
Phunziro la VIKING-3 linasonyeza kuti Tivicay anali wothandiza 63% mwa odwala akuluakulu omwe amatsutsa magulu osiyanasiyana a kachilombo ka HIV, kuphatikizapo integrase inhibitors Isentress (ratelgravir) ndi elvitegravir (yomwe imapezeka mu pilisi imodzi, mlingo wosakaniza mankhwala, Stribild ) .
Phunziro la SINGLE linawulula kuti odwala ku Tivicay anali ndi zotsatira zochepa zotsalira chifukwa cha mankhwala osokoneza bongo kuposa Atripla (tenofovir + emtricitabine + efavirenz). Pambuyo pa masabata makumi awiri ndi awiri, maphunziro a 2% pa regimen yochokera ku Tivicay satha kuperekedwa ndi 10% mwa iwo omwe amalandira Atripla.
Mlingo
- Akuluakulu: 50mg piritsi, kamodzi tsiku ndi tsiku
- Achikulire omwe ali ndi integrase inhibitor yotsutsana nawo : 50mg piritsi, kawiri tsiku ndi tsiku
- Ana 12 ndipakati (akulemera 88 lbs / 40kg kapena kuposa): piritsi 50mg, kamodzi tsiku ndi tsiku
Kuwonjezera apo, kwa ana amene amathandizidwa ndi Sustiva (efavirenz), Aptivus (tipranavir) + Norvir (ritonavir), Lexiva (fosamprenavir) + Norvir (ritonavir), kapena rifampin, mlingo wa Tivicay ndi 50mg, kawiri tsiku lililonse.
Sitikudziwikanso ngati Tivicay ikugwira ntchito kwa ana okhala ndi integrase-resistant associated.
Ulamuliro wa Mankhwala
Tivicay ingatengedwe kapena wopanda chakudya, ndi nthawi iliyonse ya tsikulo.
Zotsatira Zogwirizana
Zotsatira zowonongeka kwambiri (zomwe zimachitika pa 2% kapena zochepa) zimakhala:
- Kusagona
- Mutu
- Chizungulire
- Nausea
Kuyanjana kwa Mankhwala kapena Kusagwirizana
Tikosyn (dofetilide), omwe amagwiritsidwa ntchito pochiza arrhythmia (chizoloŵezi chopanda mtima), amatsutsana kuti agwiritsidwe ntchito ndi Tivicay.
Pofuna kupeŵa kugwiritsira ntchito mankhwala osokoneza bongo, dalitsani dokotala kuti mukugwiritsa ntchito mankhwala kapena mankhwala owonjezera:
- Mankhwala a antiretroviral : Sustiva (efavirenz), Intelence (etravirine), Viramun (nevirapine), kuphatikizapo Lexiva (fosamprenavir) + Norvir (ritonavir), kapena Aptivus (tipranavir) + Norvir (ritonavir)
- Mankhwala osokoneza bongo: Trileptal (oxcarbazepine), Dilantin (phenytoin), Phenytek (phenytoin), Luminal (phenobarbital), kapena mankhwala a carbamazepine monga Carbatrol, Equetro, Tegretol, Teril, kapena Epitol
- Mankhwala a Rifampin: Rifadan, Rifater, Rifamate, Rimactane
- Mankhwala ochizira matenda a shuga a Metformin: Fortamet, Glucophage, Glumetza, Riomet
- Wotchedwa St. John's Wort
Mfundo
- Odwala omwe amavutika ndi vutoli atayamba Tivicay ayenera kuonana ndi adokotala mwamsanga . Chithandizo chiyenera kuimidwa ndipo chithandizo chamankhwala chikafunidwa ngati kuthamanga kumatsagana ndi malungo, minofu kapena ululu wothandizira, zilonda zamtundu kapena zilonda, kufiira kapena kutupa kwa maso, kutupa kwa nkhope kapena pakamwa, kapena mavuto opuma. Odwala omwe kale anali ndi maganizo opatsirana ndi Tivicay sayenera kuyesedwa ndi mankhwala pambuyo pa kuthetsa zizindikiro.
- Tivicay iyenera kutengedwa maola awiri musanafike maola asanu ndi limodzi mutatha kutenga mankhwala otchedwa aluminium kapena magnesiamu omwe ali ndi antacids kapena laxatives, zowonjezera zitsulo, mavitamini a calcium, mankhwala opatsirana, kapena Carafate (sucralfate) ogwiritsira ntchito pochiza zilonda za duodenal.
- Udziwitseni dokotala za chiwindi chomwe mungakhale nacho musanayambe Tivicay. Pakhoza kukhala chiopsezo chowonjezereka kwa mavuto a chiwindi mwa ena, makamaka kwa anthu omwe ali ndi matenda a chiwindi (HVB), hepatitis C (HCV) , kapena kuwonongeka kwa chiwindi. Mavitamini a chiwindi ayenera kuyang'aniridwa nthawi zonse monga gawo la kuyesera magazi kwa munthu kutenga Tivicay.
> Zotsatira:
Laibulale ya National National Medicine. "Pulogalamu ya TIVICAY (dolutegravir sodium), filimu yophimbidwa." Bethesda, Maryland; adakonzedwanso mu August 2013.
ViiV Healthcare. "ViiV Healthcare imalandira mgwirizano wa FDA wa Triumeq." London, England; ndondomeko yomasuliridwa yomwe idaperekedwa 22 August 2014.
Walmsley S.; Antela, A .; Clumeck, N .; et al. "Dolutegravir (DTG; S / GSK1349572) + abacavir / lamivudine kamodzi tsiku ndi tsiku amawerengetsera kuposa tenofovir / emtricitabine / efavirenz: zotsatira za masabata 48 - SINGLE (ING114467)." 52nd Interscience Conference on Antitimicrobial Agents ndi Chemotherapy. San Francisco; September 9-12, 2012; Mfundo Zenizeni H-556b.
Nichols, G ;; Grossberg, R .; Lazzarin, A .; et al. "Kuletsa Mankhwala Opatsirana pogwiritsa Ntchito Dolutegravir M'magulu Opanda Kulephera pa Zomwe Zili M'kati mwa Mlingo: Mlungu 24 Zotsatira za Phase 3 Zachokera ku VIKING-3." Msonkhano wa 11 ku International Congress pa mankhwala opatsirana pogonana mu HIV (HIV11). Glasgow, Scotland; November 11-15, 2012; Zosamveka O232.