Ngakhale zilipo, monga momwe zilili tsopano, palibe mankhwala ochizira matenda a m'mimba (IBS), pali mitundu yambiri ya mankhwala omwe ali ndi zizindikiro za IBS . Zina mwazo zimangotchula chizindikiro cha matenda enaake, pamene mankhwala atsopano akubwera pamsika omwe akukonzekera kuti athetse mavuto omwe akutsutsana ndi IBS.
Izi ndizo mankhwala oyambirira omwe amagwiritsidwa ntchito pochizira munthu amene ali ndi IBS.
Kumbukirani kuti mankhwala onse sangakhale abwino kwa inu. Kodi mankhwala omwe dokotala angakulimbikitseni, ngati alipo, adzadalira mbiri yanu yachipatala, kuopsa kwa zizindikiro zanu, ndi vuto lanu lalikulu la m'mimba. Zina mwa mankhwalawa zimapezeka ndi mankhwala okhaokha, pamene zina zimapezeka pamsika. Kumbukirani kuti chifukwa chakuti chinachake chikupezeka popanda mankhwala sikukutanthauza kuti n'koyenera. Onetsetsani kuti adzalandile dokotala wanu asanayese chinthu chatsopano.
Zambiri Zogwiritsa Ntchito Mankhwala a IBS
Mitundu yotsatirayi imatha kuuzidwa kwa aliyense amene akukumana ndi IBS, mosasamala za mtundu wawo womwewo . (Pitirizani kuwerenga kuti mudziwe zambiri za mankhwala omwe amathandiza kwambiri kutsekula m'mimba-makamaka IBS (IBS-D) ndi kudzimbidwa-makamaka IBS (IBS-C).
Mankhwala a Antispasmodic
Mankhwala a Antispasmodic amalembedwa kawirikawiri kwa IBS, monga momwe angathandizire kuthetsa ululu m'mimba ndi kupondaponda komwe kumakhala ndi IBS.
Komabe, iwo amakhala ndi zotsatira zowonongeka ndipo, motero, sangakhale chisankho chabwino kwa munthu yemwe ali ndi IBS-C. Monga momwe kafukufuku wokhudzana ndi chitetezo cha antispasmodics kwa ntchito ya nthawi yayitali ndi yoperewera, mankhwalawa akhoza kukhala oyenerera kwa nthawi yayitali yokha. Zomwe zimagwiritsidwa ntchito ndi antispasmodics zomwe zimaperekedwa kwa IBS ndizo:
- Bentyl (dicyclomine)
- Buscopan (hyoscine chotsitsa)
- Anaspaz, Cystospaz, Levbid, Levsin (hyoscamine)
- Mebeverine (osati ku United States)
Kudetsa nkhaŵa
Nthawi zambiri matenda opatsirana pogwiritsa ntchito amagwiritsidwa ntchito pang'onopang'ono ngati njira yothetsera zizindikiro za IBS pamene ali ndi makhalidwe abwino komanso amakhala otetezeka kuti agwiritse ntchito nthawi yaitali. Dokotala wanu angakulimbikitseni kuti mutha kupanikizika ngakhale mutakhala ovutika maganizo. Ngati muli ndi vuto lachisokonezo kapena nkhawa yomwe mumakhala nayo ndi IBS yanu, ndibwino kuti dokotala wanu asankhe njirayi.
Kuwonjezera pa kuchepetsa kupweteka, kuponderezana nthawi zina kumakhala ndi zotsatira zina zomwe zimaphatikizapo kuyamwa. Choncho, dokotala wanu angasankhe yekha malinga ndi momwe muli ndi IBS-C kapena IBS-D. Mitundu yowonjezera imakhala ndi tricyclic anti-depressants yakale (zabwino kwa IBS-D) kapena zina mwazatsopano zomwe mungasankhe monga serotonin reuptake inhibitors (SSRIs) serotonin-norepinephrine reuptake inhibitors, zomwe zingakhale bwino kwa IBS-C.
Njira Zothandizira Mankhwala Otsekula m'mimba - Zambiri za IBS
Njira yachikale yothandizira kutsekula m'mimba imapitirizabe kukhala Imodium (loperamide), yomwe imapezeka pa-counter. Komabe, mankhwala awiri a mankhwalawa posachedwapa adalandira chivomerezo cha FDA chochiza IBS-D:
Xifaxan (rifaximin) ndi antibiotic yomwe poyamba idagwiritsidwa ntchito pochiza kutsekula m'mimba komanso mabakiteriya aang'ono m'mimba (SIBO).
Ndizovomerezeka ndi FDA ndi "mankhwala osadziletsa IBS." Xifaxan imagwira ntchito mosiyana kwambiri ndi ma antibayotiki ambiri chifukwa sichilowa m'magazi anu koma zimakhala zowunikira mabakiteriya m'matumbo anu aang'ono ndi aakulu. Zimagwiritsidwa ntchito kukhala zotetezeka kwa maphunziro opita masabata awiri.
Viberzi (eluxadoline) ndi mankhwala omwe amakhudza opioid receptors m'thupi lanu kuti athetse zizindikiro za ululu m'mimba ndi kutsekula m'mimba kwa anthu omwe ali ndi kutsekula m'mimba-makamaka IBS (IBS-D). Chifukwa Viberzi ndi mankhwala ophika, amadziwika kuti ndi mankhwala ozunguliridwa ndipo pali nkhawa zina zokhudzana ndi chizoloŵezi choledzera.
Njira Zothandizira Mankhwala Osungirako Kugwiritsa Ntchito IBS
Mankhwala a mitundu yonse amagwiritsidwa ntchito kwambiri kuti athetse chizindikiro cha kudzimbidwa. Miralax (polyethylene glycol), yomwe sichifunikiranso mankhwala, ndiyo yokha yomwe adafufuza ndi ochita kafukufuku kuti athe kuchepetsa zizindikiro za IBS. Kafukufuku wina adapeza kuti kunali kosavuta kuchepetsa kudzimbidwa ndi zidole zofewa, koma osati pofuna kuthetsa ululu wa IBS.
Pakalipano pali mankhwala ochepa omwe angapangidwe ndi mankhwala a IBS-C:
Linzess (linaclotide) imagwira ntchito pamatope mkati mwa chigawo cha zakudya kuti muwonjezere kuchuluka kwa madzi m'matumbo anu aakulu. Kuphatikiza pa IBS-C, Linzess ndi FDA yovomerezedwa kuti azitha kuchipatala matenda aakulu (CIC) akuluakulu. Ku Ulaya, mankhwalawa akutchedwa Constella.
Amitiza (Lubiprostone) nawonso FDA amavomereza kuti azisamalira CIC pamodzi ndi IBS-C. Amitiza amagwiritsa ntchito mapuloteni mkati mwa m'mimba mwa matumbo kutulutsa madzi ambiri. Mwamwayi, kunyozetsa kumakhala kosavuta komanso kusasangalatsa mbali ya Amitiza.
Resolor / Resotran (prucalopride) ndi mankhwala omwe amapezeka ku Canada ndi ku Ulaya. Kuteteza kumagwira ntchito pa serotonin yokhala ndi ubongo wa m'mimba mkati mwa matumbo ndipo, choncho, m'kalasi lomwelo la mankhwala monga Zelnorm , mankhwala omwe achotsedwa pamsika chifukwa cha zotsatira zoyipa. Komabe, Resolor inalinganizidwa mosiyana kuti tipewe mavuto aakulu. Kuyambira tsopano, Resolor imavomerezedwa ndi European Medicines Agency kuti athe kuchipatala kwa amayi.
Mankhwala a IBS muchigawo choyesera
Mankhwala atsopano akubwera pamsika, ndipo njira zina zothetsera mankhwala zimatha kupyolera mumayesero a chitetezo. Awa ndiwo atsopano akulu; onse ali mu magawo osiyanasiyana a kuyesedwa pokhudzana ndi chitetezo chawo ndi mphamvu zawo. Kuphunzira za zomwe mungachite kungakuthandizeni kugwira ntchito ndi dokotala kuti mupange ndondomeko yothandizira IBS yanu.
Asimadoline ndi mankhwala omwe akukumana ndi ma ARV monga chithandizo cha IBS-D. Mankhwalawa amawunikira kwambiri malo ovomerezeka m'matumbo akulu; Tikuyembekeza kuti zoterezi zidzasunga zotsatira zochepa. M'mayesero oyambirira, zikuwoneka kuti mankhwala omwe amachititsa kwambiri mankhwalawa ndi kuchepetsa kupweteka kwa m'mimba komanso kuvulaza.
Elobixibat ndi mankhwala omwe akufufuzidwa ngati mankhwala a CIC. Zimagwira ntchito pochepetsa kuchepetsa kubwezeretsa kwa acids kuchokera ku ndulu, motero kuwonjezera kuchuluka kwa zidulozi mumatumbo anu akulu. Izi ndizomwe zingakuthandizeni kufulumizitsa ndondomeko ya chinyama kudzera mu colon. Pali, pakalipano, palibe kafukufuku wamankhwala okhudza luso la elobixibat ku IBS-C.
Plecanatide amagwira ntchito mofanana ndi Linzess ndipo pakalipano akukumana ndi matenda a zamankhwala monga mankhwala a IBS-C ndi CIC.
Tenapanor ndi mankhwala a matenda a impso. Zimagwira ntchito pochepetsa kuchepa kwa sodium m'magazi; Kuwonjezeka kwa sodium kumangowonjezera kuchuluka kwa madzi m'matumbo akuluakulu. Chifukwa chaichi, Tenapanor akukumana ndi matenda a zachipatala monga mankhwala a IBS-C.
Mawu Ochokera
Ngakhale kuti mukutha kuona kuti pali mankhwala osiyanasiyana a IBS, anthu ambiri omwe ali ndi IBS amawona kuti mankhwala omwe amayesa sakukwanira kuthetsa zizindikiro zawo. Nthawi zina amapezeka ndi zotsatirapo ndipo amasiya kumwa mankhwala. Mwamwayi, mankhwala si okhawo omwe amapezeka mankhwala a IBS. Zosankha zanu zina zimaphatikizapo njira zowonongeka , zakudya zosinthika , ndi mankhwala othandizira. Pitirizani kulankhulana ndi dokotala kuti mufike pa njira yabwino yothandizira.
Zotsatira:
Lacy, B., Chey, W. & Lembo, A. "Njira Zatsopano Zogwiritsira Ntchito Zopatsira Matenda Otupa Amadzimadzi" Gastroenterology & Hepatology 2015 11: 1-19.
Lazaraki, G., Chatzimavroudis, G. & Katsinelos, P. "Posachedwapa kupita patsogolo kwa mankhwala opatsirana ndi matenda opweteka" World Journal of Gastroenterology 2014 20: 8867-8885.
Peyton, L. & Greene, J. "Irritable Bowel Syndrome: Pakalipano ndi Kuchulukitsa Chithandizo Chapafupi" Pharmacy & Therapeutics 2014 39: 567-572, 578.
J J, Vanuytsel T, Corsetti M. "Masiku Ano Kukonzekera kwa Kutentha Kwambiri Kwambiri Kwambiri." Kugonjetsa Amagazi 2016; 34: 566-573.
Trinkley, K. & Nahata M. "Kugwiritsa Ntchito Mankhwala Osokoneza Bongo la Irritable Bowel Syndrome" Kudyetsa 2014 89: 253-267.