Azimayi ambiri amawona zizindikiro zosasangalatsa m'masiku omwe asanakhalepo. Zizindikirozi zingaphatikizepo kuvutika maganizo kumasintha kapena kungomva pang'ono.
Koma, ngati mukuvutika ndi maganizo aakulu omwe amayamba nthawi zonse masiku asanu ndi awiri kapena asanu musanafike nthawi yanu ndipo mutatha nthawi yochepa yopuma magazi mumakhala ndi matenda opatsirana pogonana (PMDD) .
PMDD Ndi Matenda a Maganizo
Matenda a maganizo amayamba chifukwa cha kusokonezeka komwe kumapangitsa kuti ubongo wanu uzikhala ndi maulendo olankhulana. Sitingathe kumvetsetsa momwe maganizo anu akuyendetsera, koma tikudziwa kuti kulamulira maganizo anu kuli mu ubongo wanu. Kafukufuku wasonyeza kuti maganizo anu ndi chifukwa cha kuyanjana kovuta pakati pa nyumba za ubongo, maulendo a ubongo, ndi ubongo wanu kapena mankhwala a ubongo.
Chimene chimachititsa ubongo kusinthika kumene kumayambitsa matenda a maganizo ndi malo a kufufuza mwakhama. Zotsatira za kafukufuku wamakono zikusonyeza zifukwa zingapo zomwe zingayambitse matenda a maganizo, kuphatikizapo:
- Zamoyo zimayambitsa
- Kusokonezeka maganizo
- Mankhwala
- Matenda achilendo
Ngati mukudwala ndi PMDD, vuto lanu la matenda a maganizo ali ndi zovuta zina: mahomoni anu obala.
Zimene Timadziwa Zomwe Zilipo Chifukwa cha PMDD
Mahomoni anu obereka, omwe ndi estrogen, ndi progesterone, amagwirizana ndi mankhwala anu a ubongo ndipo amatha kugwira ntchito zina mu ubongo wanu, kuphatikizapo maganizo anu.
Estrogen ndi progesterone zimapangidwa ndi mazira anu ndipo mawere a mahomoniwa amasinthasintha panthawi ya msambo.
Izi ndizomwe kusintha kwa mahomoni kumayambiriro kwa amayi, koma sikuti amayi onse amavutika ndi PMDD. Choncho, zosiyana ndi zomwe zikuchitika pakati pa 3 ndi 8 peresenti ya amayi omwe ali ndi PMDD.
Ngati muli ndi PMDD mulibe kusamvana kapena kutaya kwa hormonal. M'malo mwake, zimaganiziridwa kuti mukhoza kumvetsetsa kusintha kwa ma hormone komwe mukupita kumwezi.
Chimene sitimvetsetse bwino ndi chimene chimachititsa chidwi.
Progesterone / Allopregnanolone
Njira zazikuluzikulu za matenda a PMDD ndizakuti zizindikiro zanu zimangokhala pokhapokha pokhapokha ngati mukupita kumwezi. Nthawi ya luteal ndi nthawi pakati pa ovulation ndi tsiku loyamba la nthawi yanu. Patsiku lokhazikika la masiku 28, izi zikufanana ndi masiku 14 mpaka 28.
Mukamawotchera, mazira anu amayamba kuonjezera kupanga progesterone. Progesterone imasandulika kukhala hormone ina yotchedwa allopregnanolone (ALLO). Mapulogalamu a Progesterone ndi ALLO akupitirizabe kukula mpaka mutayamba nthawi yanu, pomwe amasiya. Lingaliro limodzi ndilo kuti ngati muli ndi PMDD mumaganizira kwambiri kuchotsedwa kwa progesterone.
Lingaliro lina ndilokuti ALLO ndi amene amachititsa zizindikiro zanu chifukwa zimagwirizanitsa ndi obwana a GABA mu ubongo wanu. GABA ndi mankhwala a ubongo kapena a neurotransmitter omwe, atagwiritsidwa ntchito kuzipangizo zawo mu ubongo, amayendetsa chisokonezo ndi nkhawa. Ndipotu, chifukwa cha mowa ndi benzodiazepine ndizokhalira ndi nkhawa komanso kumakhala kuti amamangiriza ku GABA amalandirira mu ubongo wanu ndikuchita monga GABA yanu ya ubongo.
Kawirikawiri, ALLO imagwira ntchito mu ubongo wanu monga mowa ndi benzodiazepines.
Koma akazi omwe ali ndi PMDD amaganiza kuti chinachake n'chosiyana ndi ntchito yachilendo ya ALLO. Chotheka chiripo kuti pali kusintha kwa mphamvu ya GABA yothandizira ku ALLO panthawi yomwe amatsatira. Kapena, mwinamwake pali vuto mu luteal phase production ALLO. Kulephera kwa ALLO kungachititse kuwonjezeka kwa nkhawa, kusakwiya, ndi kusokonezeka kwa PMDD.
Estrogen
Kachilinso, poyesera kuzindikira zomwe zingayambitse PMDD, nkofunika kukumbukira kuti PMDD imapezeka pokhapokha pamene mukupita kumwezi.
Pambuyo pa ovulation, pamene ma progesterone akukwera, magulu anu a estrogen akugwa. Kuchepa msanga kwa mlingo wanu wa estrogen ndi chifukwa china chokha cha PMDD.
Tikudziwa kuti estrogen imagwirizana ndi mankhwala angapo a ubongo omwe amachititsa kuti muzisangalala. Imodzi mwa mankhwalawa amachititsa serotonin. Serotonin imathandiza kwambiri thupi lanu mwa kukhalabe ndi moyo wabwino. Serotonin ikuphatikizapo kuyang'anira ntchito zambiri, kuphatikizapo maganizo anu, kugona, ndi chilakolako chanu. Serotonin imakhudzanso malingaliro anu, kapena momwe mumapezera, kuyendetsa, ndikuzindikira zambiri kuchokera ku malo anu.
Estrogen imalimbikitsa zotsatira zabwino za serotonin. Zikuganiziridwa kuti ngati muli ndi PMDD, serotonin yanu imatha kukhala yocheperachepera kuti isrogen ikhale yochepa pakapita nthawi. M'mawu ena, ngati muli ndi PMDD kuchepa kwa estrogen panthawi yomwe mukupita kumapeto kwa msambo wanu kungachititse kuti muzitha kugwedezeka m'magulu a serotonin mu ubongo wanu. Maseŵera otsika a serotonin amagwirizana ndi maganizo opsinjika maganizo, zilakolako za zakudya, ndi kusokonezeka kwa chidziwitso cha PMDD. Izi zikuthandizira kugwiritsa ntchito serotonin receptor inhibitors (SSRIs) pofuna kuthandizira PMDD.
Kusokonezeka maganizo
Ngati muli ndi PMDD n'zotheka kuti muli ndi mbiri yaumunthu, kukhumudwa, kapena kugonana. Ena, koma osati onse, amayi omwe ali ndi PMDD ali ndi mbiri yowopsa kwambiri.
Ochita kafukufuku akuyang'ana momwe mbiri iyi yothetsera nkhawa ingayambitsire ku PMDD. Njira imodzi yomwe ikuwoneka yolumikizana ndi mgwirizano pakati pa kupanikizika kwanu ndi ALLO. Kawirikawiri, ALLO imakula nthaŵi zina chifukwa cha kupanikizika kwakukulu, kumayesa kuchepetsa komanso kudziletsa. Kafukufuku wamakono asonyeza kuti kuyankha kwa ALLO kupsinjika kwambiri kumachepetsedwa pamene akuvutika maganizo.
Kuzindikira momwe mavuto angapangitsire kapena kuwonjezereka zizindikiro za PMDD pakalipano ndi malo ofufuzira. Ndithudi, kuthekera kwa mgwirizano pakati pa kupanikizika kwanu ndi PMDD kumapereka njira yodziwika yothetsera mzere woyamba wa PMDD, kuphatikizapo kusintha kwa moyo wanu ndi kuchepetsa nkhawa.
Kuteteza thupi kumthupi / kutupa
Pali mgwirizano wokhazikika pakati pa kupsinjika maganizo ndi momwe thupi lanu limagwirira ntchito. Ngakhale kuti matenda a PMDD ndi osiyana ndi matenda opatsirana kusiyana ndi kuvutika maganizo kwakukulu (MDD), pangakhale mbali ina yomwe chitetezo chanu cha mthupi chingathandize PMDD.
Chifukwa cha kusintha kwachidziwitso kumatenda opatsirana ndi chitetezo cha mthupi komanso kutupa pa nthawi ya msambo, amayi omwe ali ndi zizindikiro zina zotupa monga gingivitis ndi matenda opatsirana amatha kuona kuwonjezereka kwa zizindikiro zawo mu gawo la luteal.
Kafukufuku wakale mderali amasonyeza kuti amayi omwe ali ndi zizindikiro zofunikira zowonjezera m'mimba angakhale ndi kuwonjezereka koyankhidwa mu gawo la luteal poyerekeza ndi amayi omwe ali ndi zizindikiro zochepa.
Genetics
Matenda aumtima amadziwika kuti amayendetsa mabanja. Kukhudzidwa kwanu kuti mukhale ndi matenda a maganizo mu moyo wanu umachokera kwa makolo anu kudzera mu majini anu. Monga momwe thupi lalitali ndi mtundu wa diso limatengera, momwemonso pali matenda enaake, kuphatikizapo khansa ndi kupsinjika maganizo. Mpaka posachedwapa, palibe ma genetic otero a PMDD.
Azimayi omwe ali ndi PMDD amamvetsetsa kusintha kwa ma hormone pa nthawi yomwe amatha msambo. Ofufuza a NIH anafufuza chifukwa chake. Chimene iwo adapeza ndi chakuti amayi omwe ali ndi PMDD asintha mwa chimodzi mwa ma gene omwe amachititsa momwe amachitira ndi estrogen ndi progesterone. Mwa kuyankhula kwina, pali chibadwa cha maantimoni omwe amapezeka mwa amayi omwe ali ndi PMDD.
Kupeza uku kukutsimikiziranso ngati muli ndi PMDD. Amapereka umboni wosatsimikizirika wa sayansi kuti chinthu china cholengeka ndi chosatheka kulamulira chimapangitsa kuti maganizo anu asinthe. Zimatsimikizira kuti PMDD sizongokhala khalidwe labwino.
Koma zotsatila izi si nkhani yonse. Kupambana kwa kafukufukuyu, komabe, kulimbikitsa maphunziro ena ndikutsegula chitseko chopeza njira zatsopano zothandizira PMDD.
Mawu Ochokera
Mwachidziwikire, pali zifukwa zambiri zomwe zimakhudza chitukuko cha PMDD, koma chinthu chimodzi chotsimikizika ndi chakuti PMDD ndi mkhalidwe weni weni osati osati chinachake chimene mukuchita kapena chimene mungachifune. Mwina pali njira imodzi yomwe imakhala pakati pa kusintha kwa ma hormone ndi PMDD.
Zotheka kuti pali zifukwa zosiyanasiyana za PMDD zingathandize kufotokoza chifukwa chake mankhwala ena amakuchitirani zabwino osati kwa ena, komanso mosiyana. Ndikofunika kukumbukira izi pamene iwe ndi dokotala mukufufuza njira zosiyanasiyana zochizira zomwe zingakuthandizeni kukhala bwino ndi PMDD.
> Zotsatira:
> Hantsoo L. & Epperson CN (2015) Kuthetsa Matenda a Mitsempha Yoyamba: Epidemiology ndi Chithandizo. Curr Psychiatry Rep., 17 (11) 87. lembani: 10.1007 / s1920-015-0628-3
> Dubey N, Hoffman JF, Schuebel K, Yuan Q, Martinez PE, Nieman LK, Rubinow DR, Schmidt PJ, Goldman D. Makompyuta a ESC / E (Z), mawonekedwe enieni a maselo amtunduwu amasiyana kwambiri ndi ovarian steroids mu Premenstrual Dysphoric Matenda, Psychiatry Yambiri, January 3, 2016, do: 10.1038 / mp.2016.229.