Kuyezetsa kwa ma Genetics mu Matenda a Parkinson

Kuyesedwa kwa majeremusi mu matenda a Parkinson kungathandize kwambiri pakuzindikira

Kuyesedwa kwa majeremusi m'thupi la Parkinson kungathandize kwambiri kupeza matenda. Asayansi akuyembekeza kuti chidziwitso chopangidwa ndi ma genetics chidzatha kuchepetsa kapena kusiya kuyendetsa kwake.

Zamoyo zimatengedwera mu DNA yathu, magawo omwe ali ndi cholowa chomwe chimatsimikizira makhalidwe omwe anadutsa kuchokera kwa kholo kupita kwa mwana. Timalandira madola awiri biliyoni a majini kuchokera kwa amayi ndi abambo athu.

Amadziŵa mtundu wa maso athu, momwe timatalika, ndipo nthawi zina, timakhala ndi chiopsezo chotenga matenda ena.

Monga dokotala, ndikudziwa udindo umene ma geneethi amachititsa kuti tidziwe thanzi lathu. Mphamvu za majeremusi athu zimasiyana malinga ndi matenda, koma zinthu zonse zachilengedwe ndi genetics zimathandizira kuti chitukuko cha matenda chikule bwino.

Kuyezetsa kwa ma Genetics mu Matenda a Parkinson

Mu matenda a Parkinson, matenda ambiri ndi omwe timawatcha kuti sporadic popanda chifukwa chodziwikiratu. Mavoti omwe si "achibale" amatanthawuza kuti palibe mamembala ena omwe ali ndi Parkinson. Komabe, pafupifupi 14 peresenti ya anthu okhudzidwa ndi Parkinson ali ndi chiwerengero choyambirira (kholo, mchimwene kapena mwana) yemwe akudwala matendawa. M'mabanja amenewa, majeremusi osandulika omwe amachititsa matendawa amatha kulandira muyeso wapamwamba kapena yowonjezereka.

Achibale ambiri omwe amakhudzidwa ndi mibadwo yosiyanasiyana amapezeka m'mabanja omwe ali ndi jini la Parkinson lopambana. Chitsanzo cha mtundu umenewu ndi cholowa cha SNCA chomwe chimayambitsa kupanga puloteni yotchedwa alpha-synuclein. Mapuloteniwa amapanga matupi a Lewy omwe amapezeka mu ubongo wa anthu omwe ali ndi Parkinson.

Zosintha zina - LRRK2, VPS35, ndi EIF4G1 - ndizopatsidwa mwaufulu.

Mosiyana ndi zimenezi, kusintha kwa kusintha kwakukulu komwe kumachititsa kuti chitukuko cha matenda a Parkinson chikuyimiridwe ndi zochitika m'badwo umodzi monga mwa abale. Zosintha zachibadwa za PARKIN, PINK1, ndi DJ1 zimakhala zitsanzo za mtundu umenewu.

Izi ndi zina mwa kusintha komwe kumadziwika koma pali zambiri zimene zikupezeka nthawi zonse. Kumbutsani, komabe, kuti mitundu yambiri ya ma chibadwa ili ndi chiwerengero chochepa cha mawu kapena penetrance chimene kwenikweni chimatanthauza kuti chifukwa chakuti muli ndi jini sichikutanthauza kuti mudzalandira Parkinson. Ngakhalenso pa kusintha kwa kusintha kwa LRRK2, komwe kuli kofunikira kwambiri m'chilengedwe, kukhalapo kwa jini sikumagwirizana ndi chitukuko cha matendawa.

Kodi Kuyeza kwa Genetic kwa Parkinson Kuyenera Kuchitanji?

Dokotala wanu angaganize ngati Parkinson wanu akupeza kuti akubwera ali wamng'ono (osakwana zaka 40), ngati achibale angapo m'mbiri ya banja lanu apezeka kuti ali ofanana, kapena ngati muli pachiopsezo cha Parkinson ya pabanja lanu mtundu (omwe ali ndi Ashkenazi Ayuda kapena North-African maziko).

Komabe, ndi phindu lanji kuti muyesedwe kale?

Zomwe zidziwitso zingakhale zofunikira pa kulera kwa anthu ena ngakhale kuti ndinanenapo ngakhale kuti jini laperekedwa pa ilo sikuti likufanana ndi chitukuko cha matendawa. Komabe, chiwopsezo chiri ndipamwamba kwambiri pa kusintha kwa majini ndi zowonongeka, pafupipafupi ngati munthu ali ndi chiwerengero choyamba cha Parkinson (mwachitsanzo kholo kapena mbale) chiopsezo cha matendawa ndi oposa 4 mpaka 9 peresenti kuposa anthu ambiri.

Kumbukirani kuti pakalipano kwa munthu yemwe akuyesedwa, palibe kusintha kwa mankhwala a Parkinson awo chifukwa cha zomwe anapeza. M'tsogolomu, ngati pali mankhwala ochepetsa kuchepa kwa matendawa kapena kuteteza kuti zisapangire konse, ndiye kuti chidziwitso cha anthu omwe ali pangozi chidzakhala chofunikira kwambiri.

Mayeso a Genetics ndi Kafukufuku wa Parkinson

Ngakhale kuti sipangakhale phindu lenileni kwa inu pakalipano, zotsatira za kuyesa kwa majeremusi zingathandizire kafukufuku wina wa Parkinson mwa kulola asayansi kumvetsetsa bwino matendawa ndipo potero amakhala ndi mankhwala atsopano. Mwachitsanzo, kusintha kwa jini komwe kumatulutsa mapuloteni alpha-synuclein (SNCA) kumabweretsa mtundu wina wa matenda a Parkinson. Ngakhale kusinthika uku kumangopereka chiwerengero chazing'ono, chidziwitso cha kusintha kumeneku kwasintha kwambiri. Kuphunzira za kusintha kwa chibadwa kumeneku kunapangitsa kuti atulukira kuti alpha-synuclein imagwirizana palimodzi kuti ipangitse matupi a Lewy omwe akhala akupezeka mu ubongo wa anthu onse omwe ali ndi matenda a Parkinson osati omwe ali ndi kusintha kwa SNCA. Motero, njira imodzi yosinthira mafupa yachititsa kuti pakhale zovuta zogwirizana ndi kafukufuku wa Parkinson.

Kuyesedwa kwa majeremusi ndi chisankho chaumwini koma chidziwitso: nthawi iliyonse yomwe kuyezetsa magazi kumayang'aniridwa, makamaka pa matenda omwe palibe kusintha kwa mankhwala pogwiritsa ntchito zowonongeka, ndiye kuti ndikupempha kuti ndiwone mlangizi wa ma genetics kuti akambirane za zotsatira Mfundoyi idzakhala nayo kwa inu wodwala, ndi banja lanu.

_Zolemba:

_{Beck, James, Ph.D. "Parkinson's Insights: Kuyeza kwa Genetic ndi Inu." Parkinson's Insights: Mayeso a Zachibadwa ndi Inu . Parkinson's Disease Foundation (PDF), 26 Mar. 2013. Webusaiti. 29 Mar. 2014. http://parkinsonsdiseasefoundation.blogspot.ca/2013/03/genetic-testing-and-you.html}

_{Farrer, Matthew, MD. "Genetics: Foundation for Treatments Future Parkinson." - Parkinson's Disease Foundation (PDF) . Parkinson's Disease Foundation, Winter 2012. Webusaiti. 29 Mar. 2014. http://www.pdf.org/winter12_genetics}

_{Puschmann, Andreas. "Mankhwala a Parkinson." Genetics ya Parkinson . Association of European Parkinson's Disease Association, nd Web. 29 Mar. 2014. http://www.epda.eu.com/en/parkinsons/life-with-parkinsons/part-3/genetics-of-parkinsons}