Kodi Chithandizo cha Khansa Chingavulaze Bwanji Maungulo ndi Motani?
Kodi kutanthauza kupweteka kwa m'mapapo kuchokera ku khansa, ndingadziwe bwanji ngati ndakhala nawo, ndipo amachizidwa bwanji?
Chithandizo cha khansa chinapangitsa kuti poizoni azitha kuwonongeka.
Chimodzi mwa zotsatira zochepa za mankhwala a khansa ya magazi ndi mafuta ndi mapangidwe a mapapo. Kuwonongeka kwa mapapo amtunduwu kungathenso kutchedwa poizoni poizoni kapena poizoni poizoni.
Dongosolo la mankhwala oopsa limatha kuchokera ku kutupa kwa mapaipi mpaka kuphulika kosatha kwa mapaipi a mapapo. Akuti pafupifupi oposa 10 peresenti ya odwala omwe amalandira mankhwala a chemotherapy - makamaka mankhwala a chemotherapy omwe amagwiritsidwa ntchito kwa khansa ya magazi - adzakhala ndi zotsatira za pulmonary.
Kodi N'chiyani Chimachititsa Kuti Tizilombo Tizilombo Tizilombo Tizilombo Tizilombo Tizilombo Tizilombo Tizilombo Tizilombo Tomwe Timakhala Nafe
Kuchepetsa mankhwala oopsa ndi njira yothandizira kuti mankhwala a chemotherapy ndi radiotherapy athe. Chomwe chimayambitsa matenda a pulmonary sichimveka bwino. Komabe, asayansi atulukira zinthu zingapo zomwe amamva kuti zimathandiza kwambiri momwe mankhwala a poizoni amapangira.
- Kuyanjana pakati pa chemotherapy ndi radiotherapy ndi mamolekyu a mpweya
- Zotsatira zoopsa za DNA ya maselo a m'mapapo
- Kupweteka kwa mapapu a m'mapapo pambuyo poyambira mankhwala a chemotherapy kapena radiation
Zizindikiro za Kuopsa Kwa Uphungu
Zizindikiro za mankhwala ophera tizilombo ta mankhwala ndizosafunikira kwenikweni ndipo zingathe kusokonezeka mosavuta ndi zizindikiro zina zamapapu .
Zizindikiro zambiri za mankhwala okhudzana ndi kuwonongeka kwa mapapo ndi awa:
- Chifuwa chouma
- Kupuma pang'ono
- Kupweteka pachifuwa
- Kupuma mwamsanga
- Kuvuta kukugwira mpweya wanu
- Fever
Nthaŵi zina, zizindikiro za poizoni wa poizoni zingaoneke pakapita mankhwala, kapena zingatenge miyezi ingapo kuti zizindikiro ziyambike. Kawirikawiri, zizindikiro zokhudzana ndi kupweteka kwa mapapo zimayamba masabata 6 mpaka 8 mutangoyamba kumene.
Chifukwa zizindikirozi zimakhala zofanana ndi zina zomwe zimachitika ndi odwala khansa monga chibayo kapena kufalikira kwa maselo oopsa m'mapapo, akatswiri ayenera kulamulira izi asanayambe kupeza chithandizo cha mankhwala okhudzana ndi mankhwala oopsa. Mwa kuyankhula kwina, poizoni poizoni ndi "matenda osokonezeka."
Kodi Ndi Zotani Zambiri Zochiritsira Zochititsa Kuti Pulmonary Toxicity?
Mitundu yambiri ya mankhwala a chemotherapy yakhala ikugwirizana ndi mankhwala a poizoni. Zina mwazofala kwambiri zomwe zimagwiritsidwa ntchito pochiza magazi ndi khansa ya m'mawere ndi izi:
- Bleomycin
- Idarubicin
- Methotrexate
- Cyclophosphamide
- Busulfan
- Arsenic trioxide
Mankhwala othandizira odwala pachifuwa angayambitsenso mankhwala a poizoni . Zotsatirazi zingakhale zowonjezereka ngati mwalandira radiotherapy kuphatikizapo chemo.
Zopinga Zowopsa Poyambitsa Kachilombo Toxicity
Zinthu zomwe zimapangitsa odwala omwe ali pachiopsezo chachikulu chotulutsa poizoni amadziwika bwino ndipo nthawi zambiri amakambirana. Komabe, zotsatirazi zafotokozedwa ngati zifukwa zoopsa:
- Kuwonjezeka kwa zaka
- Chemotherapy yothandizana
- Njira ya chemotherapy administration
- Mankhwala opatsirana pogwiritsa ntchito mankhwala a chemotherapy
- Matenda a impso
- Matenda a m'mapapu oyenda pansi
- Mbiri ya kusuta
- Kutsogolo kwa asibesitosi
- Mankhwala apamwamba a chemotherapy
- Chinthu chochititsa chidwi cha Colony (G-CSF) ngati mankhwala othandizira pa matenda a bleomycin (mankhwala monga Neupogen ndi Neulasta omwe amachititsa kuti thupi lanu likhale loyera)
- Kugwiritsira ntchito mankhwala okosijeni pa mankhwala a chemotherapy
Kuzindikira Matenda Omwe Amayambitsa Kachilombo
Kudziwa odwala omwe ali ndi poizoni wamagazi akhoza kukhala kovuta kwambiri chifukwa cha zizindikiro zosadziwika komanso zosavuta zowonongeka. Kawirikawiri, akatswiri amafika pozindikira kuti pali mankhwala enaake omwe amachititsa kuti mankhwalawa asokonezeke, pambuyo pa zifukwa zina, monga chibayo , zomwe zasokonezedwa.
Madokotala amagwiritsa ntchito mayesero a magazi monga momwe magazi amawerengera m'magazi , monga chifuwa cha X-rays kapena CT , kupimidwa kwa pulmona (PFT) komanso nthawi zina bronchoscopy kuti athetse matenda kapena kufalikira kwa maselo a khansa m'mapapo monga chifukwa cha zizindikiro. Ngati palibe chifukwa china chomwe chingadziwidwe, ndipo mwakhala mukudwala mankhwala opatsirana posachedwa, katswiri wanu angadziwe kuti matenda anu a mapapu adayambitsidwa ndi khansa yanu.
Kuchiza kwa Uphungu Wauzimu
Ngati dokotala wanu akukayikira kuti mapapu anu ali okhudzana ndi mankhwala kapena mankhwala omwe mukuulandira, iwo amatha kuletsa wothandizilawo. Nthawi zina, amatha kumwa mankhwalawa ndi mankhwala enaake ochepa kapena amathetsa mankhwalawo palimodzi. Ngakhale kuti zingakhale zovuta kuti musinthe mankhwala anu, dokotala wanu sangasankhe mopepuka.
Palibe chithandizo chapadera cha kuwonongeka kwa mapapo chifukwa cha matenda a kansa, pali zinthu zingapo zomwe zingathandize ndi zizindikiro zomwe mungathe kuziwona:
- Steroids kuchepetsa kutupa m'mapapu anu
- Kugwiritsa ntchito mankhwala othandizira okosijeni
- Mankhwala osokoneza bongo kuti athandize kuchepetsa kupweteka ndikuthandizani kuthetsa mpweya wochepa
- Zosangalatsa zozizira
- Respiratory physiotherapy (pulmonary rehabilitation)
- Kusiya kusuta
- Kuchita masewera olimbitsa thupi ndi kuchita masewera olimbitsa thupi
Moyo Pambuyo Poyambitsa Kachilombo
Matenda aakulu a poizoni amatha kufa. Nthawi zina, kupweteka kwa mapapo chifukwa cha khansa kungakhale kosatha. Komabe, nthawi zambiri, odwala akamatha kupweteka kwa mapapowa, amachira bwinobwino popanda zotsalira zomwe zatsala.
Kuwongolera Iwo
Kuwonongeka kwa mitsempha kungabwere chifukwa cha chemotherapy kapena radiotherapy pochiza khansa. Pamene mankhwala athu a khansa ya magazi ndi a mongo agwira bwino, anthu amakhala ndi moyo nthawi yayitali kusiyana ndi kale lonse. Choncho, ndondomeko za chisamaliro ziyenera kulingalira za nthawi yaitali zomwe zimakhudza kupuma kwa poizoni kuphatikizapo zomwe zingathe kuchiza izi.
Zotsatira
Maldonado, F., Limper, A., ndi J. Jett. Kachilombo koyambitsa matenda kamene kamagwiritsidwa ntchito ndi mankhwala oteteza tizilombo toyambitsa matenda: Cytotoxic othandizira. Zaposachedwa. Kusinthidwa 09/28/15. http://www.uptodate.com/contents/pulmonary-toxicity-associated-with-antineoplastic-therapy-cytotoxic-agents
Pal, S. Bleomycin Yachititsa Kuvulaza Kwambiri. Zaposachedwa. Kusinthidwa 09/14/15. http://www.uptodate.com/contents/bleomycin-induced-lung-injury
Shippee, B., Bates, J., ndi K. Richards. Udindo wa kuwonetsetsa ndi kuwunika kwa poizoni ya bleomycin poizoni. Journal of Oncology Pharmacy Chitani . 2015 Mar 2. (Epub patsogolo pa kusindikiza).