Genetics & Kugwirizanitsa m'banja
Funso:
Kodi Fibromyalgia Ndi Yachilengedwe?
"Anthu angapo m'banja mwathu ali ndi fibromyalgia ndipo tsopano ndikuonetsa zizindikiro zambiri. Zimenezi zimandipangitsa kudandaula kwambiri za ana anga-kodi ndawagonjetsa?" Kodi fibromyalgia ndi cholowa? "
Yankho:
Ichi ndi chodetsa nkhaŵa. Ndizowopsya kuganiza kuti tikhoza kukhala ndi matenda osokoneza bongo pamodzi ndi ana athu mosadziŵa.
Nkhani yabwino ndi yakuti ngakhale atakhala ndi chiopsezo chachikulu, satsimikiziridwa kuti ali ndi fibromyalgia.
Malingana ndi kafufuzidwe, chikhulupiliro cha tsopano ndi chakuti fibromyalgia sichibadwa mwachikhalidwe, pomwe kusintha kwa jini imodzi kumayambitsa khalidwe linalake. Icho chimatchedwa monogenic, ndipo chimayendetsa zinthu monga mtundu wa buluu; Komabe, umboni umasonyeza kuti majini anu akhoza kukupangitsani kuti mukhale ndi fibromyalgia, koma m'njira yovuta yokhudzana ndi majini ambiri, omwe amatchedwa polygenic.
Kodi Kusiyana Ndi Chiyani?
M'chikhalidwe chokha, chikhalidwe chokhala ndi moyo, choloŵa cholowa, majeremusi enieni omwe mumalandira kuchokera kwa makolo anu ndicho chachikulu chodziwitsa ngati mungapeze matenda. Mwachitsanzo, mu cystic fibrosis, mwana wa makolo omwe onse odwala matendawa ali ndi mwayi wokwana 25 peresenti yokhala ndi cystic fibrosis. Iwo amatha kupeza kusintha kwa genetic kusintha kapena iwo samatero. Ngati atenga kusintha, amapeza matendawa.
Pogwiritsa ntchito ma polygenic, sizili zophweka chifukwa majini anu amangotanthauza kuti matenda ena ndi otheka pamkhalidwe wabwino . Izi zikutanthauza kuti pali chiopsezo chachikulu kuposa anthu ena, koma osatsimikizika. Kawirikawiri, zifukwa zina ziyenera kukhala zowonongeka kuti zimayambitsa matenda.
Mu fibromyalgia, zifukwa zina zingaphatikizepo izi:
- magwero ena a ululu wosatha
- matenda okhaokha
- matenda ogona
- kupanikizika kosatha
- matenda opatsirana
- malingaliro osadziwika a ubongo
Akatswiri ena amaganiza kuti zinthu zachilengedwe monga kutengeka kwa zakudya kapena kukhala ndi poizoni zingathandizenso.
Izi zikutanthauza kuti mwana wanu adzalandira chibadwa cha fibromyalgia , koma izo sizikutanthauza kuti iye adzatha. Zingatenge zochitika zina zowonjezera kuti zitsatire njira imeneyo.
Genetic Links mu Fibromyalgia
Ochita kafukufuku anayamba kuyang'anitsitsa za chibadwa cha fibromyalgia zakale kale chifukwa zimakonda kuthamanga m'mabanja, zomwe zimatchedwa "masango". Ntchito zambiri zaphatikizapo mapasa ofanana. Thupi lafukufuku likukula kuyambira m'ma 1980.
Chimene taphunzira ndi chakuti pafupifupi theka la chiopsezo chotchulidwa ndi majini ndi theka limatsimikiziridwa ndi zinthu zina monga zomwe zalembedwa pamwambapa.
Kafukufuku amatsimikizira kuti mabanja amapezeka kwambiri ndipo amasonyeza kuti kupweteka kwambiri (malo omwe zimakhala zopweteka kwambiri) ndizofala kwa achibale omwe alibe fibromyalgia.
Tikuyamba kupeza chithunzi cha zinthu zomwe zimayambitsa matenda a fibromyalgia.
Pakalipano, tili ndi maphunziro ambiri omwe amasonyeza kugwirizana ndi majini ambiri, koma zambiri mwa maphunzirowa sizinafotokozedwe.
Zovuta zachibadwa zomwe zanenedwa ndi maphunziro oyambirira zimaphatikizapo majeremusi omwe amakhudzana ndi odwala matendawa omwe amachitidwa ndi fibromyalgia, kuphatikizapo serotonin , norepinephrine , dopamine , GABA ndi glutamate . Ena amagwiritsidwa ntchito mu ubongo wambiri, kumenyana ndi matenda a tizilombo, ndi othandizira ubongo zomwe zimagwiritsa ntchito opioid (opha ululu) komanso mankhwala osokoneza bongo (monga chamba ).
Pamene tiphunzira zambiri za mayina a ma gene, ofufuza angadziwe kuti ndi ndani mwa iwo omwe amachititsa chiopsezo chotenga fibromyalgia komanso ngati wina angagwiritsidwe ntchito kuti azindikire kapena kuthetsa vutoli.
Kodi Zimenezi Zikutanthauza Chiyani kwa Mwana Wanu?
Ndizowopsya kuganiza kuti mwana wanu ali ndi chiopsezo chachikulu chothera ndi fibromyalgia. Chinthu chofunikira kukumbukira ndi chakuti palibe chomwe chitsimikiziridwa.
Pakalipano, sitidziwa zomwe zingathandize kuchepetsa chiopsezo, koma phunziro limodzi limasonyeza kuti mapasa omwe ali ndi nzeru zam'maganizo sakanatha kudwala. Nzeru zanu ndizochita zanu:
- kuti muzindikire komanso kuti muziyenda bwino
- kufotokoza momwe mumamvera
- kuthana ndi maubwenzi mwachilungamo komanso mwachifundo
Kulimbikitsa luso limeneli mwa mwana wanu kungakuthandizeni. Kupsinjika maganizo ndi chifukwa chodetsa nkhaŵa, choncho yesetsani kuphunzitsa mwana wanu njira zothetsera vuto . Ngati mwana wanu akuwoneka kuti akulimbana ndi zinthu izi, mungafunefune katswiri wothandizira omwe angamuthandize.
Chifukwa chakuti ululu wosapitirira kale umakhala woopsa wa fibromyalgia, mungafune kudziwa makamaka momwe kuvulala kumachiritsira ndipo ngati mwana wanu ali ndi migraines kapena "akulira ululu." Katswiri wanu wa ana ayenera kukhala ndi chithandizo cha mankhwala.
Tilibe umboni wosonyeza kuti kudya zakudya zabwino komanso thupi lathunthu kumachepetsera chiopsezo cha mwana wanu chotenga fibromyalgia, koma nthawi zonse amakhala ndi malingaliro abwino.
Ngati mumakhudzidwa ndi chilichonse chokhudzana ndi thanzi la mwana wanu, onetsetsani kuti muli ndi ana anu.
Ndipo kumbukirani kuti "simunapereke" mwana wanu chilichonse. Ndipotu, kuzindikira kwanu koyambirira kungakhale komwe kumawatsogolera.
Zotsatira:
Becker RM, ndi. al. Revista brasileira de reumatologia. 2010 Dec; 50 (6): 617-24. Chiyanjano pakati pa khalidwe la chilengedwe, nkhawa ndi APOE mitundu ya mitundu yosiyanasiyana ya fibromyalgia imaganiza kutsimikiza.
Burri A, Lachance G, Williams F. Twin kafukufuku ndi ma genetic anthu. 2015 Apr; 18 (2): 188-97. Njira yotsutsana ya monozygotic yomwe imakhalapo chifukwa cha ululu wambiri mwa amayi.
Matsuda JB, et. al. Revista brasileira de reumatologia. 2010 Apr; 50 (2): 141-9. Serotonin receptor (5-HT 2A) ndi mankhwala a catechol-O-methyltransferase (COMT) omwe amachititsa kuti majeremusi apangidwe.
Reeser JC, et. al. PM & R: magazini ya kuvulala, ntchito, ndi kukonzanso. 2011 Mar 3 (3): 193-7. Apolipoprotein e4 genotype amachititsa kuti munthu asamavutike ndi matenda a fetromyalgia.
Xiao Y, W W, Russell IJ. Journal of rheumatology. 2011 Jun; 38 (6): 1095-103. Mankhwala opanga mavitamini a beta2-adrenergic receptor amagwirizana ndi mapuloteni a guanosine omwe amachititsa kuti thupi lisamagwire bwino matenda a fibromyalgia.