Mutu Wodwala Wogwiritsira Ntchito ndi Zotsatira Zotsatira za Topical Fluorouracil
Njira yowonongeka ya basal cell carcinoma -mtundu wamba wa khansa yapakhungu padziko lonse-ndiyo mankhwala opangira (khungu) kokha monga Efudex (fluorouracil). Ngati dokotala wamuuza Efudex, mawu oyamba awa adzakuthandizani ndi zomwe mukufunikira kuzigwiritsa ntchito moyenera.
Zindikirani kuti mfundoyi silingathenso kuteteza, kuyanjana kapena zotsatira za mankhwalawa. Ngati muli ndi mafunso okhudza mankhwala alionse omwe mukuwutenga, onetsetsani kuti muyang'ane ndi dokotala wanu wa zamankhwala.
Mwachidule
Efudex (maina ena amodzimodziwa ndi Carac ndi Fluoroplex) ndi zonunkhira zamtengo wapatali zomwe zimagwiritsidwa ntchito pochiza basi basal cell carcinoma pamene njira zowonongeka sizingatheke, monga momwe zimakhalire ndi zilonda zambiri kapena malo ovuta owonetsera pamaso kapena khungu. Amagwiritsidwanso ntchito pochiza actinic keratosis (yomwe imatchedwanso kuti dzuwa keratosis), yomwe ingayambitse matenda oopsa kwambiri a squamous cell carcinoma ngati sanachotsedwe.
Efudex ndi mankhwala a chemotherapy (a "antimetabolite") omwe amalepheretsa kulengedwa kwa DNA ndi RNA, zomwe ndi zofunika kuti magawano ndi kukula zikule. Izi zimayambitsa kufa kwa maselo odwala khansa, omwe amamwa kwambiri fluorouracil kuposa maselo abwino. Mu mawonekedwe ake amphamvu kwambiri, Fluorouracil amagwiritsidwanso ntchito pochita mawere, m'mimba, m'mimba, ndi m'magazi ochepa .
Mphamvu
Kuchuluka kwa mankhwala a basal cell carcinoma ndi fluorouracil pafupifupi 93 peresenti, kuchokera pa kufufuza kwa 113 zilonda mwa odwala 54.
Komabe, kutalika, mosavuta mosavuta khungu la basal cell kachipatala ayenera kuchiritsidwa ndi opaleshoni chifukwa zowonongeka ndi pafupifupi 100 peresenti. Mosiyana ndi opaleshoni, Efudex sangathe kusiya mabala kapena kutulutsa khungu kansalu.
Kafukufuku wina tsopano akuyang'ana momwe Efudex kiriri zimakhalira m'zigawo zosaoneka za thupi, komanso momwe zimagwirizanitsa ndi maiquimod (Aldara) kirimu ndi mankhwala opangira mankhwala .
Mwachitsanzo, mu phunziro limodzi lachi German la odwala ndi actinic keratosis , mankhwala a imiquimod amachititsa kuti ziwombankhanga ndi zotsatira zowononga bwino ziyereke bwino poyerekeza ndi mankhwala ozunguza bongo ndi fluorouracil. Lankhulani ndi dokotala wanu za chithandizo chomwe chili chabwino kwa inu.
Ntchito
Kwa basal cell carcinoma, ndibwino kuti 5 peresenti ya fluorouracil ayambe kugwiritsidwa ntchito katatu patsiku pangongole yokwanira kubisa zilonda kwa masabata atatu kapena 6. Mankhwala angapangidwe kwa nthawi yaitali mpaka masabata 10 mpaka 12 zisanafike. Pofuna kugwiritsa ntchito mankhwalawa, gwiritsani ntchito pulogalamu ya thonje, kapena gwiritsani ntchito magolovesi ngati mutayigwiritsa ntchito. Ngati akugwiritsidwa ntchito ndizitsulo zopanda chitetezo, ndikofunika kusamba m'manja bwino mutapempha mankhwalawa. Pewani kugwiritsa ntchito maso, mphuno, kapena pakamwa.
Zotsatira Zotsatira
Kawirikawiri, malo omwe amachiritsidwa akhoza kukhala osagwiritsidwa ntchito pafupipafupi, ndipo kawirikawiri kwa milungu ingapo mutatha mankhwala. Zotsatira za fluorouracil zimachitika m'zigawo zinayi:
- Gawo loyamba kutupa: Pa sabata yoyamba ya ntchito, kutupa kofatsa kumachitika.
- Kutupa: Pa masabata otsatirawa, kufiira ndi kutupa kumachitika ndi kutumphuka ndi kutentha.
- Kachilombo koyambitsa matendawa: Zilonda zimatsuka pamene khungu limatuluka.
- Gawo lachiritso: Pa masabata opitirira 1 mpaka 2, khungu latsopano limakula kumalo ochiritsira.
Zotsatira zapadera zomwe sizikusowa chithandizo chamankhwala (kuwuza dokotala wanu kapena katswiri wa zaumoyo ngati apitiliza kapena akuvutitsa) zikuphatikizapo:
- khungu lofiira kapena lakuda
- Kutentha kwa nthaka (kutaya kwa khungu la pamwamba)
- Kukhumudwa kwa diso kuphatikizapo kuyaka, kuyabwa, kukhudzidwa, kupweteka, kapena kutsirira
- kuwonjezeka kwa khungu mpaka dzuwa ndi kuwala kwa ultraviolet
- ululu ndi kuyaka kwa dera lomwe lakhudzidwa
- kuuma, kukulitsa kapena kutupa kwa malo okhudzidwa
- Kuthamanga kwa khungu, kuyabwa kwa dera lomwe lakhudzidwa
- chifundo
Zotsatira zowopsa kwambiri zomwe muyenera kulengeza kwa dokotala wanu kapena katswiri wa zamankhwala mwamsanga mungaphatikizepo:
- ululu wamimba
- Kutsegula m'mimba
- kusanza
- malungo
- zovuta
Chenjezo ndi Kuyanjana
Mafuta a kirimu a mafudex sayenera kugwiritsidwa ntchito ndi amayi omwe ali ndi mimba, poganizira kutenga pakati, kapena kuyamwitsa chifukwa zingathe kuvulaza mwanayo. Iyenso sayenera kugwiritsidwa ntchito ngati muli ndi dihydropyridine dehydrogenase (DPD) yolephera ya enzyme, popeza zotsatira zake zingakhale zoopsa. DPD ndi cholowa chomwe chimapezeka pa 3 peresenti mpaka 5 peresenti ya chiwerengero cha anthu ndipo amafunika kuti apange mayeso apadera kuti azindikire. Kuwonjezera pamenepo, auzeni dokotala ngati:
- akukumana ndi mankhwala a radiation
- kale anali ndi zochitika zachilendo kapena zosavomerezeka kwa fluorouracil, mankhwala enaake, mankhwala ena, zakudya, utoto, kapena zotetezera
Pewani dzuwa ngati momwe mungathere pogwiritsira ntchito Efudex chifukwa zingakulepheretseni zotsatira zake. Ngati atakhala ndi dzuwa, avala chipewa ndipo agwiritseni ntchito kofiira. Monga nthawi zonse, pewani zisa zowonongeka , zomwe zakhala zikugwirizana kwambiri ndi squamous cell carcinoma ndi melanoma.
Zotsatira
- "Carac Kulongosola Mfundo." sanofi- aventis US LLC.
- "Efudex Kulongosola Zomwe Ambiri Amanena." Valeant Pharmaceuticals.
- Krawtchenko N, Roewert-Huber J, Ulrich M, Mann I, Sterry W, Stockfleth E. "Kafukufuku wophunzira 5% wa imiquimod vs. topical 5-fluorouracil ndi mankhwala opangira mankhwala m'magulu osatetezeka omwe ali ndi actinic keratoses: zotsatira zake zowonjezera kuphatikizapo kutsata kwa zaka 1. " Br J Dermatol . 157 Zowonjezera 2: 34-40.
- Newman MD, Weinberg JM. Mankhwala opatsirana pogwiritsa ntchito mankhwala a actinic keratosis ndi basal cell carcinoma. Kudula . 79 (Suppl) 4: 18-28.