Corticosteroid-Imayambitsa Matenda a Mitsempha - Zimene Mukuyenera Kudziwa

Corticosteroid-Imayambitsa Matenda a Mitsempha ndi Yopeweratu ndi Yotheka

Corticosteroids ndi mtundu umodzi wa mankhwala a steroid. Nthawi zina mawu akuti "steroid" amagwiritsidwa ntchito mosiyana ndi "corticosteroid".

• Kodi kusiyana pakati pa Anabolic Steroid & Corticosteroids ndi chiyani?

Malingana ndi ACR, anthu oposa 30 miliyoni a ku America angakhudzidwe ndi matenda omwe amachitidwa ndi corticosteroids. Steroids monga prednisone , amagwiritsidwa ntchito monga mankhwala pa matenda ambiri opweteka ndi omwe amadzimva okha , monga:

• mphumu
• nyamakazi ya nyamakazi
• lupus
• matenda opweteka

Amagwiritsidwanso ntchito pochiza matenda ambiri. Ngakhale kuti ma steroid amathandiza kwambiri kuchiza matendawa, ndiwonso omwe amachititsa kuti anthu azidwala matenda osokoneza bongo .

• Zoonadi za Corticosteroids (Steroids)

Corticosteroids & Kutsatsa Mafupa

Corticosteroids imakhudza calcium ndi fupa zamatenda m'njira zambiri.

• Steroids imachepetsanso kuchuluka kwa calcium yomwe imatuluka m'mimba
• Steroids imapanga calcium excretion kudzera impso

Zinthu ziwirizi zimagwirizanitsa kuti ziwonongeke m'maganizo a calcium yomwe imayambitsa ionized. Izi zimachititsa kuti zilonda za parathyroid ziwonjezere chitetezo cha hormone ya parathyroid (PTH), yomwe imadziwika kuti secondary hyperparathyroidism. Maseŵera a PTH owonjezeka amachititsa kuwonjezeka kwa mafupa, pamene thupi limayesetsa kukonza calcium yochepa pochotsa calcium mafupa kupita m'magazi.

Corticosteroids imathandizanso kuchepetsa miyeso ya mahomoni ogonana:

• estrogen (mwa akazi)
• testosterone (mwa amuna)

Zotsatirazi zimachepa zikugwirizana ndi kuwonjezeka kwa mafupa.

Corticosteroids imathandizanso kufooka kwa minofu, zomwe zingayambitse kusagwira ntchito komanso kuphatikizapo mafupa. Chinthu chinanso choopsa cha corticosteroids ndi chakuti akhoza kuthandizira mafupa mwachindunji mwa kupondereza ntchito ya mafupa (opaleshoni).

Zitsanzo za Kutayika kwa Matenda

Pali mitundu iwiri ya minofu ya mfupa: chowongolera ndi chimbudzi.

• Cortical bone imagwiritsa ntchito chipolopolo cha mafupa ndipo imakhala ndi mafupa 80%
• Matenda a Trabecular (otsala 20%) amapezeka mkati mwa fupa

Pfupa lililonse m'magazi muli mitundu yonse ya fupa, koma kukula kwake kumasiyana. Corticosteroids makamaka amachititsa kuti mafupa amwalire m'madera amenewa a mafupa omwe ali olemera kwambiri mumthambo, monga msana.

Dose ndi Nthawi

Kutaya kwa mafupa kumachitika mofulumira kwambiri m'miyezi yoyamba 6 mpaka 12 ya mankhwala ndipo imadalira onse awiri:

• mlingo
• nthawi

Zina mwazifukwa zomwe zimayambitsa matenda a osteoporosis zingakhale ndi zotsatira zowonjezera mafupa, monga:

• zaka
• chikhalidwe
• matenda opondereza

Mwachitsanzo, amuna okalamba pa steroid akhoza kukhala ndi mafupa akuluakulu komanso oopsa kwambiri kusiyana ndi amuna okalamba. ACR akuganiza kuti popanda njira zothandizira, anthu pafupifupi 25 peresenti ya corticosteroid ya nthawi yaitali adzasweka.

Mliri wa corticosteroids ndi mphamvu yowononga fracture ngozi. Ngakhale sizikudziwika ngati pali mlingo wochepa wa pansipa umene sipangapezeke mafupa, kafukufuku waposachedwapa apeza steroid yosakaniza kuti ikhale ndi zotsatira zochepa pamatenda a pfupa pamene imayendetsedwa muyezo woyenera komanso popanda dongosolo la systemic steroids.

Kutha kwa Osteoporosis

Matenda a steroid-omwe amachititsa kuti matendawa asatuluke ndi othandizidwa komanso ochiritsidwa. Malingana ndi ACR, anthu omwe ali pa corticosteroids ayenera kukhala ndi mafupa a mchere wochulukitsa mayeso ochitidwa. Mayesowa apereka chithunzi choyambirira chomwe chiyenera kuyang'anila kusintha kwa fupa. ACR imalimbikitsanso kudya tsiku ndi tsiku kwa 1500 mg. calcium ndi 400-800 UU wa vitamini D. Calcium ndi vitamini D zingathandize kuchepetsa mphamvu ya calcium ndi mahomoni oyenera, ndipo amatha kusunga mafupa kwa odwala omwe ali ndi mlingo wochepa wa mankhwalawa.

Matenda Oseoporosis

Mankhwala opatsirana osteoporosis omwe amavomereza ndi FDA kwa corticosteroid-omwe amachititsa kuti matenda a matenda a m'mimba azipezeka:

• Actonel (Risedronate) pofuna kupewa ndi kuchiza
• Fosamax (Alendronate) kuchipatala

Mu ogwiritsira ntchito corticosteroid, mankhwala onsewa amapereka zotsatira zopindulitsa pa msana ndi minofu ya minofu ya minofu ndipo amachepetsa kuchepa kwa msana. Matenda a Estrogen ndi Miacalcin (Calcitonin) angathandize kusunga msana m'mimba mwa amayi am'mbuyo poyambitsa corticosteroids, komabe FDA imavomereza kuti matenda a osteoporosis asokonezeke.

Kusintha kwa moyo

• Kuchotsa kusuta ndi kumwa mowa, n'kofunika kuchepetsa chiopsezo cha steroid-induced osteoporosis.
• Kuchita masewera olimbitsa thupi ndi kuchita masewera olimbitsa thupi kungathandize kuteteza mafupa ndi minofu, pamene kuwonjezeka kwa mphamvu ya minofu ndi kuchepetsa ngozi ya kugwa.
• Kupewera ndi kugwa kwachitsulo ndikofunikira kwambiri kwa anthu okalamba komanso kwa omwe adzizidwa ndi zofooka za steroid.

Mfundo Yofunika Kwambiri

Njira zothandizira osteoporosis ziyenera kuyamba kumayambiriro, makamaka poyambitsa mankhwala a corticosteroid. Akatswiri amalimbikitsa kugwiritsa ntchito mankhwala ochepa kwambiri a steroid kwa nthawi yochepa kwambiri, ndipo, ngati n'kotheka, opaleshoni kapena zam'mimba zotchedwa corticosteroids ziyenera kugwiritsidwa ntchito.

_Chitsime:

_{Glucocorticoid-Inachititsa Osteoporosis, NIH ORBD ~ NRC, 12/2000}