Matenda a osteoarthritis amatchulidwa kuti nyamakazi. Komabe, ofufuza tsopano akupeza kuti siziri zokhudzana ndi kansalu kakang'ono. Palinso mbali zina za anatomy, monga subchondral bone, yomwe imathandiza kwambiri pa matenda a osteoarthritis.
Kodi Subchondral Bone ndi chiyani?
Fupa lamatumbo ndilo fupa la mafupa omwe ali pansi pa kanyumba kamodzi.
a -chondral amatanthauza kadoti, pamene chiganizo chapansi mwa njira pansipa. Thupi la subchondral ndi lopweteka kwambiri m'magulu olemera.
Lili ndi mitsempha yambiri ya magazi yomwe imapereka zakudya ndi mpweya ndi kuchotsa zinyalala. Monga katsamba kamene kalibe magazi enieni, kugwirizana kwambiri ndi fupa la vascularized subchondral bone ndilo limene limapangitsa kanyamatayo kudya. Ziwiya zimenezi zimapereka hafu ya hydration, oxygenation, ndi shuga kwa kanyumba kake. Thanzi ndi ntchito ya fupa la subchondral lidzasintha kusiyana ndi thanzi la katsamba komwe kuli pamwamba pake.
Chimene Chimachitika mu Osteoarthritis
Mu mafupa a osteoarthritis, mafupa a subchondral amakula kwambiri kuposa nthawi zonse. Umboni umasonyeza kuti kuphulika kumachitika musanayambe kugwidwa ndi khunyu, zomwe zimasonyeza kuti mafupa a subchondral amachititsa kuti mafupa a osteoarthritis ayambe. Kafukufuku apeza kuti asanatuluke mafupa a osteoarthritis pangakhale kuchulukanso kwa chiwongoladzanja cha feteleza ya subchondral, monga momwe anayesera ndi kuwongolera.
Njira zina zimapangitsa fupa kuti likhale lolimbikitsidwa kuti liyambe kugwetsa ndikudzikonza yokha. Izi mwachibadwa zimatulutsa zinthu zina zamagetsi zomwe zimayambitsa mafupa ndi karoti.
Thupi la mafupa a subchondral ndilokutsika kapena kupweteka kwa pamwamba.
Zikuwonekera m'magazi oyambirira a kneelaarthritis ndipo kupezeka kwake kumatanthawuza ngati kutayika kwa kanyumba kumapangidwanso komanso ngati chipinda cha mawondo chidzasintha. Nthenda ya mafupa a mtundu wa edema monga zilonda zam'mimba ndi mafupa a mafupa amphongo amagwiritsidwa ntchito palimodzi. Nthano imodzi ndi yakuti kuvala ndi kugwedezeka pa bondo kumayambitsa tizilombo tating'onoting'ono zomwe nthawi zonse zimakhala zokonzekera. Ntchitoyi imapanga mavitamini ndi mapuloteni omwe angakhale ndi zotsatira zowonjezera pamtunda.
Akatswiri ofufuza apeza kuti ziwalo za mafupa a subchondral zimapanga ma cytokine angapo komanso kukula (mapuloteni) omwe amachititsa kutupa ndi kusintha kwa minofu. Zomwe zikuchitika ndi zomwe mankhwala angakhale omwe amafunikira kwambiri kufufuza. Kaya mafupa a subchondral amasintha ndi zomwe zimabala imfa ya cartilage kapena ngati akutsatira ndi funso la nkhuku-kapena-dzira kuti apitirize kufufuza. Choyamba chimabwera ndi chiyani? Kodi njira ina ikuyendetsa zonse? Kodi zonsezi zimayambitsidwa ndi kuvala ndi kulira kapena pali chifukwa china chachikulu?
Mitundu ina ya Subchondral Bone mu Osteoarthritis
- Chitsulo Chitsamba : Izi zimawoneka m'magazi a osteoarthritis, ndi thumba lodzaza madzi lomwe limachokera pamodzi. Ndizofala kwambiri pa X-ray koma safuna kuthira kapena mankhwala ena.
- Subchondral Sclerosis : Izi zimachulukitsidwa ndi mafupa kapena kuphulika mu subchondral wosanjikizidwa, kuwonedwa pa X-ray kwa osteoarthritis. Ndi chimodzi mwa ziwonetsero za chikhalidwechi.
Zotsatira:
> Zamoyo zamakono ndi subchondral bone mu osteoarthritis. Biorheology. 7/26/2004. Kafukufuku Wofufuza: October 2000 - Buku la 35 - Nkhani 10 - pp 581-588
Zamakono za Rheumatology. Vesi 13, Nambala 1. March 2003. http://www.springerlink.com/content/j0d9m9yak10085hc/
Frank W. Roemer, ndi. al. "Mitsempha ya mafupa a mafupa amphongo imagwirizanitsidwa kwambiri ndi, ndipo imaneneratu kuti pang'onopang'ono mafupa a subcondral akuyendera: kuphunzira kwakukulu." Osteoarthritis Cartilage 2010 Jan; 18 (1): 47. yofalitsidwa pa Intaneti 2009 Sep 10. do: 10.1016 / j.joca.2009.08.018