C. kusiyana ndi matenda ndi zovuta kufalikira
Clostridium difficile ( C. diff ) imayambitsa matenda ambiri a mabakiteriya m'tchire. Mukhoza kukhala ndi mabakiteriya, koma mulibe zizindikiro. Kapena, mukhoza kuwona zizindikiro zochokera m'mimba yowononga kupita ku zoopsa kwambiri, nthawi zina kupweteka kwa moyo (colination of colon).
Anthu ambiri omwe ali ndi kachilombo ka Clostridium difficile sadzadwala.
Komabe, nkofunika kukumbukira kuti mukhoza kuthetsa matenda popanda kuchidziwa. Anthu omwe amadwala kwambiri ndiwo omwe ali kuchipatala kapena kumwa mankhwala opha tizilombo.
Momwe imafalikira: Matendawa amapezeka munthu wina amene wakhala akutenga mankhwala opha tizilombo kapena ali ndi matenda ena omwe amabwera ndi mabakiteriya. Izi zimachitika pamene amasamutsa mabakiteriya kuchokera ku zinthu zonyansa zam'madzi kapena zonyansa pamakamwa awo kapena mphuno.
Clostridium difficile ndi tizilombo toyambitsa matenda omwe angapangitse spores omwe amapulumuka m'miyezi kwa miyezi. Muzipatala zachipatala, spores imafalikira kuchokera kwa wodwala-mpaka-wodwala, komanso ochokera kuchipatala kuti apirire.
Momwe zimayambitsa matenda: Chithandizo cha matenda a bakiteriya ndi mankhwala opha tizilombo amatha kupha mabakiteriya omwe amakhalanso, omwe amatchedwanso "microflora," omwe amakhala mumtundu wanu. Tizilombo toyambitsa matenda timateteza kachilomboka, koma ngati palibe, tizilombo toyambitsa matenda, monga Clostridium difficile (yomwe imagonjetsedwa kwambiri ndi maantibayotiki ambiri kuposa mabakiteriya omwe amagwiritsa ntchito microflora) amatha kutenga malo awo ndikuyambitsa matenda.
Clostridium difficile imabweretsa poizoni zomwe zimayambitsa kutsegula m'mimba ndi maselo owopsa m'koloni, zomwe zimayambitsa kupanga zilonda (zilonda) mu colon. Ma poizoni amachititsa kutupa kwakukulu, ndipo maselo omwe amamwalira ndi ntchentche zimatha kupanga "pseudomembrane," zomwe zimayendera matendawa.
Mu 2006, Clostridium difficile yotchedwa Clopridium difficile yotchedwa NAP1, yomwe imapanga poizoni kawiri kuposa mafinya ena, inapezeka kuti ndiyo yomwe imayambitsa matenda a colon omwe akuwonjezeka kwambiri ndi kufa.
Mu November 2008, vuto lopweteka la NAP1 linanenedwa kukhala lopitirira 20 kuposa lomwe linaganiziridwa kale. (Kupweteka kungakhale koyambitsa ziphuphu kuyambira 2000.)
Ndani ali pangozi? Anthu onse angathe kutenga kachilomboka, koma anthu amene akhala akumwa maantibayotiki kapena omwe ali kuchipatala ali pachiopsezo chotenga matenda oopsa. Zina mwazimene zimawonjezera chiopsezo cha matenda a clostridium difficile amakhala ndi nthawi yayitali yachipatala, zaka zoposa 65, matenda oopsa kwambiri, ndikukhala m'zipatala za nthawi yaitali. Ana obadwa kumene sakhala ndi matenda chifukwa sakhudzidwa ndi poizoni ya Clostridium difficile .
Zizindikiro ndi Zizindikiro: Chizindikiro chachikulu ndikutsegula m'mimba, katatu kapena kuposera patsiku kwa masiku awiri. Zizindikiro zina zimaphatikizapo malungo, kunyowa, kusowa kwa njala, ndi ululu m'mimba .
Kuzindikira: Pali mayesero angapo omwe amapezeka kwa Clostridium difficile , kuphatikizapo omwe amawona poizoni wapadera mu zitsulo ndi mabakiteriya chifukwa cha tizilombo toyambitsa matenda. Kuthamanga kwakukulu muwerengero loyera la maselo kungakhalenso chizindikiro.
Kuchiza: Kugwiritsira ntchito masiku khumi a antibiotics, monga oral vancomycin kapena metronidazole, akulimbikitsidwa. Komabe, popeza matenda angayambe chifukwa cha mankhwala ena oyambirira, wina angafunikire kukhalabe ndi mankhwala oyenera.
Chithandizo cholondola choyesera , chomwe chimatchedwa fecal bacteriotherapy , chimaphatikizapo kuchotserako mankhwala osokoneza bongo kuchokera kwa wothandizira wathanzi kuti asinthire kusamvana kwa mabakiteriya m'matumbo. Tizilombo toyambitsa matenda tizilombo toyambitsa matenda tafafanizidwa ndi antibiotic ndipo C Diff akhoza kukula; Kuika nkhuku kumathandiza kuti tizilombo toyambitsa matenda tiyambe kubzala.
Kugonjetsa ndi Zovuta: Anthu ambiri omwe amatenga matenda a Clostridium difficile adzakhala ndi matenda otsekula m'mimba. Matenda owopsa, monga matenda a colitis, amatha kuchitika ndikusowa chithandizo. Popanda kuchipatala, colitis ikhoza kukhala matenda aakulu, monga fulminant colitis, omwe amafunika kuchitidwa opaleshoni yomweyo.
Kupewa: Chifukwa cha matenda a Clostridium difficile amapezeka makamaka akamagwiritsa ntchito maantibayotiki, ndikofunika kuletsa kugwiritsa ntchito mankhwala opha tizilombo pochiza matenda omwe ali ofunikira. Kuphatikiza apo, kutsuka kwa manja nthawi zambiri komanso kutaya thupi kumayenera kuchitidwa. Mankhwala osokoneza bongo samachotsa C. diff spores, kotero kusamba m'manja ndikofunikira kwambiri.
Zotsatira:
Zomwe zimachitikira Clostridium difficile Infections. Maofesi a Kuletsa ndi Kuteteza Matenda.
Sukulu ya National US Inpatient Healthcare Facility Clostridium difficile Survey. . APIC Research Foundation.
Salyers AA ndi Whitt DD. Bacterial Pathogenesis: Njira Yapang'ono. © 1994, American Society for Microbiology, Washington, DC. pp. 282-289.
Sunenshine RH ndi McDonald LC. Matenda a Clostridium difficile : okhudzana ndi matenda oyamba tizilombo toyambitsa matenda. Cleveland Clinic Journal of Medicine. 2006; 73: 187.