Kodi akhoza kugwirizana ndi lymphoma?
Paul Langerhans anabadwira ku Berlin, Germany, pa July 25,1847, mwana wa dokotala wina wa ku Germany. Popita kukaphunzira mankhwala monga bambo ake, wamng'onoyo anapeza chinthu chofunika kwambiri koma adakali wamng'ono. Zomwe anapeza ndizo zomwe zimadziwika kuti maselo a Epangerermans, omwe ndi ofunika kwambiri pamtundu wotchedwa Langerhans cell histiocytosis.
Kuzindikira ma Lellshans Dendritic Maselo
Langerhans analowa nawo mpikisano wotsegulidwa ndi University of Berlin. Wasayansi wina wotchedwa Julius Cohnheim anali atayamba kale njira yodziŵira mitsempha pogwiritsa ntchito zida zapadera za golide ndi microscopy yowala.
Pogwiritsira ntchito njira za Cohnheim za golide ya mchere m'chaka cha 1868, Langerhans amawonetseratu zithunzi ndipo adalongosola kena khungu khungu lomwe silinali ngati maselo ena a khungu - iye adalongosola ngati dendritic chifukwa linali ndi nthambi zofanana ndi mtengo; koma adanenanso kuti sizinali zowawa. Mwa kuyankhula kwina, ilo silinakhale ndi melanin ya pigment yomwe ilipo mu maselo ena otchedwa melanocytes, omwe ali nthambi, ndipo ndi maselo omwe khansa ya melanoma imayamba.
Pa nthawiyi, iye adawongolera selo lachilombochi losakhala ndi mtundu wa mtundu wa mtunduwu kuti adziwonetse kupyolera mu khungu kwa dongosolo la mitsempha. Patatha zaka zopitirira zana, asayansi amadziwa kuti maselo a Langerhans a khungu amakhala ndi ntchito zofunika kwambiri m'thupi .
Mu 1973, Dr. Inga Silberberg anapeza kuti maselo a Langerhans a "epidermal" amaimira "malo opambana kwambiri a chitetezo cha mthupi." Masiku ano, maselo a Langerhans amaonedwa kuti ndi gulu la ma maselo osokoneza bongo, ndipo ndilo gawo lophunzitsidwa bwino kwambiri.
Maselo a Langerhans omwe amapezeka pakhungu amalingaliridwa kukhala ngati antigen maselo omwe akubwera.
Matenda a antigen ndiwo maselo omwe mawonekedwe a chitetezo cha m'thupi amatha kuzindikira. Ma cell antigen (APCs) ndi maselo omwe amagwira ntchito pojambula antigen, kuwatsindika, ndi kuwawonetsa mwachindunji kuti maselo ena am'thupi azidziwitsidwa kuti alipo antigen. Mothandizidwa ndi APCs, maselo oyera a mitsempha yambiri amatha kuzindikira ndi kuyankha tizilombo toyambitsa matenda ndi othawa ena.
Makhalidwe a Cell Listhans Histiocytosis (LCH)
Selo la Langerhans histiocytosis, kapena LCH, limasankhidwa ku nthawi yakale, "histiocytosis X," koma mayina onsewa amapezeka mu zolemba zachipatala. LCH kwenikweni ndi gulu la matenda omwe ali ndi kukula kosalamulirika kwa maselo a mtundu wa Langerhans. Zitha kuchitika pa msinkhu uliwonse, ngakhale sizikuwoneka mwa anthu akuluakulu. Ngakhale kuti LCH yadziŵika kwa zaka pafupifupi zana, asayansi samvetsabe zonse zomwe zimayambitsa.
LCH nthawi zambiri imagwirizanitsidwa ndi malo osakwatiwa kapena amodzi omwe amawoneka kuti akusowa pazithunzi zojambulapo-malo omwe, atagwiritsidwa ntchito, amasonyeza kuti fupa lamaloti latengedwa m'malo mwake ndi hertiocytes ndi nuclei yoboola nyemba.
Himtiocytes, monga macrophages kapena maselo osungunula, ndi maselo a chitetezo kuwononga zinthu zakunja pofuna kuteteza thupi ku matenda.
Mankhwala otchedwa hetiocytes, limodzi ndi ma lymphocytes, macrophages, ndi eosinophils, amatha kupha pafupifupi liwalo lililonse koma makamaka khungu, maselo, mapapo, thymus, chiwindi, spleen, fupa la mafupa, kapena dongosolo la mitsempha.
Kodi Zidzakhala Bwanji ndi Lymphoma?
Akatswiri ena amanena kuti LCH ingakhale kukula kwa maselo a Langerhans mothandizidwa ndi chemotherapy kapena radiotherapy kwa matenda a Hodgkin. Ichi ndi chimodzi mwa ziphunzitso zambiri.
Mavuto angapo a selo la Langerhans seti histiocytosis yokhudzana ndi malignant lymphoma adanenedwa kale. Komabe, milandu yomwe inanenedwa, yakhala ikuchitika ndi malignant lymphoma , komanso kutsatira lymphoma.
LCH imafala kwambiri kwa ana kuyambira zaka imodzi mpaka zitatu, zomwe zingawoneke zochititsa mantha, koma kumbukirani kuti LCH ndi yosawerengeka.
Zizindikiro zimadalira malo omwe amagwira nawo ntchito ndipo matendawa amakhala ochepa chabe ku khungu limodzi-monga fupa, mwachitsanzo, pafupifupi theka la milandu. Nthawi zina kupweteka kwa fupa sikungakhale ndi zizindikiro, koma nthawi zina pangakhale kupweteka kumalo osungira mafupa. Kuchita khungu kumawonekera pafupifupi 40 peresenti ya milandu, ndipo chizindikiro chodziwika kwambiri cha khungu ndi chiphuphu chofanana ndi chiwindi chofanana ndi matenda a yisiti.
LCH ikhoza kukhala yovuta kudziwa, koma kumbukirani kuti kuyendera nthawi zonse kwa dokotala wanu ndi kukambirana momasuka kumapangitsa mwayi wodziwa ngati chinachake sichiri chachilendo.
> Zotsatira:
> Diapedia. The Livingbook Buku la Matenda a Shuga. Paul Langerhans.
> Jaitley S, Saraswathi T. Pathophysiology ya Langerhans Maselo. Journal of Oral and Maxillofacial Pathology: JOMFP . 2012; 16 (2): 239-244.
> Langerhans P. Uber Die Nerven Der Menschlichenhaut. Archives of Pathological Anatomy 1868; 44: 325-37.
> Li X, Deng Q, Li YM. Mmene Maselo a Langerhans Anapangidwira Matenda a Hodgkin Pambuyo pa Matenda a Hodgkin. Maselo ndi Ochipatala Oncology. 2016; 5 (1): 27-30.
> Sat Kut Cell Langerhans Histiocytosis: Kubwereza Zotsatira Zomwe za Society Histiocyte. Matenda a Dokotala . 2008 May-Jun. 25 (3): 291-5.