Zokwanira za HDL
Monga aliyense akudziwira, chotupa cha HDL ndi "cholesterol chabwino," chifukwa miyezo ya HDL yowonjezera yakhala ikugwirizana ndi chiopsezo chochepa cha matenda a mitsempha yamthambo. HDL imatulutsa mafuta ambiri m'thupi ndipo imabweretsanso ku chiwindi. Motero, ofufuza akhala akuyesa kupanga chithandizo chomwe chidzawonjezera ma CDL, ndipo izi zidzakuthandizani kuchotsa cholesterol "choipa".
Izi zakhala zikukhumudwitsa kwambiri.
Njira imodzi yofukufuku imene poyamba inkawoneka yodalirika kwambiri ikupezeka mu mafilimu a HDL - mawonekedwe a HDL omwe "amatsanzira" zotsatira za ApoA, HDL lipoprotein.
- Werengani za cholesterol ndi triglycerides
Kodi HDL Mimetics ndi Chiyani?
Monga ma lipoproteins onse, HDL particles ali ndi lipids (pakalipa, cholesterol), ndi mapuloteni apadera omwe amanyamula lipid kudzera m'magazi. Mapuloteni omwe amapanga HDL lipoproteins ndi banja la mapuloteni wotchedwa ApoA. ApoA ndi "chogwiritsira ntchito" cha particle ya HDL. NdiAA yomwe imasonkhanitsa cholesterol yochulukirapo kuchokera ku makoma ozungulira ndikunyamula. Cholesterol ya HDL yomwe timayesa ndi kuyesa magazi ndi cholesterol yomwe imachotsedwa ku minofu, ndipo ikubwerera ku chiwindi kuti ipangidwe.
Ndizomveka kuti, ngati tingathe kuchulukitsa kuchuluka kwa mapuloteni a ApoA m'magazi athu, tikhoza kuwonjezera kuchuluka kwa kolesterolini, ndipo mosakayikira, kuchepetsa chiopsezo cha matenda a atherosclerosis.
Mafilimu a HDL ndi mankhwala omwe amatsanzira, monga momwe angathere, mapuloteni a ApoA. Zimakhala zokonzera HDL particles. Ambiri ali mu chitukuko, koma kafukufuku ndi chitukuko chakhala chikuchedwa ndi kuchepetsa.
Zochitika ndi HDL Mimetics
Chidziwitso choyamba chachipatala chomwe chili ndi HDL mimetic chinafotokozedwa mu 2003.
Mafilimu a HDL otchedwa ApoA-1 Milano, omwe amagwiritsidwa ntchito ngati majeremusi asanu ndi awiri omwe amachititsa kuti asatengeke, amachititsa kuti anthu ambiri azikhala ndi matenda oopsa kwambiri. (Kuchuluka kwa shrinkage kwenikweni kunali kakang'ono, koma kunali kupindika, ndipo kunali kofunika kwambiri.)
ApoA-1 Milano inawululidwa pophunzira anthu 40 ochokera ku tawuni yaing'ono ku Italy omwe ankadziwika kuti akhala ndi moyo wathanzi komanso wathanzi, ngakhale kuti atachepetsedwa kwambiri ndi ma CDL. Ofufuza anapeza kuti anthuwa anali ndi "HD" ya HDL (ApoA-1 Milano) yomwe siinapezedwe ndi kuyesa magazi nthawi zonse, koma izi zakhala zothandiza kwambiri kuteteza matenda a mtima. Ochita kafukufuku adatha kupanga chiwerengero cha DNA chomwe chinapanga HDL yatsopano, ndipo kenakake anawonjezera DNA yatsopano ku mabakiteriya a laboratory, -kupanga "fakitale" kuti apange ApoA-1 Milano.
Kafukufukuyu anachititsa chidwi kwambiri pakati pa akatswiri a cardiologist ndipo, chifukwa cha nkhani zapadera, pakati pa anthu onse.
Koma m'zaka zapitazi tamva mwachidwi za ApoA-1 Milano.
Pakhala pali ntchito pang'ono kumbuyo, komabe. Ufulu wa ApoA-1 Milano wasintha manja kangapo, ndipo makampani ambiri osokoneza bongo amadziwika kuti akugwira ntchito pa mafilimu a HDL.
Koma pakadali pano zikuwoneka bwino kuti njira yopangira mankhwalawa ndi, kunena zochepa, zovuta komanso zodula.
Kuwonjezera apo, mu 2014 kachiwiri kachilombo ka HDL (CER-001, kochokera ku Cerenis Therapeutics) kanayesedwa mu mayesero a zachipatala otchedwa CHI-SQUARED, ndipo sankatha kusonyeza phindu lochepetsa mapepala.
Kodi Mimetics a HDL Amayima Kuti?
Chidwi chachepa kwambiri kuyambira chaka cha 2003. Mankhwalawa atsimikizika kuti ndi ovuta kwambiri kuti apange ndi kupanga, ndipo chifukwa cha zotsatira za CHI-SQUARED sichiyenera kugwira ntchito zonse. Ngakhale kuti sitidziwa bwinobwino, zikuwoneka ngati makampani akuluakulu osokoneza bongo athandizidwa nawo.
Iwo akulimbikitsidwa ndi makampani ang'onoang'ono omwe alibe zochepa.
Kuwonjezera pamenepo, chidwi cha akatswiri ofufuza kukula kwa matenda a HDL monga njira yothetsera matenda a mtima chathepa kwambiri m'zaka zaposachedwapa, ndi kulephera kwakukulu kwa CETP zowononga ngati torcetrapib, ndipo posachedwapa, niacin. Makampani ogwiritsa ntchito mankhwala osokoneza bongo akhala akugwiritsa ntchito mankhwala osokoneza bongo akhala akuyesera kupeza mankhwala osokoneza bongo omwe amachulukitsa msinkhu wa HDL ndikuchepetsa matenda a mtima, osagwira ntchito. Okayikira akuyamba kukayikira lonse "HDL hypothesis," mwachitsanzo, kuti ma HDL apamwamba amakhala abwino nthawi zonse.
- Werengani za "mdima" wa cholesterol wabwino.
Kotero kupanga HDL kumapitirizabe kukula ndipo kungakhale kosangalatsa kwambiri kuchiza. Koma pali ntchito yochuluka yomwe iyenera kuchitidwa. Ndipo ngakhale kuyesayesa uku kutuluka, mankhwala amtundu uwu amafunika kuti aziperekedwa (pa nthawi yomwe amadziŵika nthawi ndi nthawi) mwachindunji; ndipo tapereka zaka zomwe tikuyesetsa komanso ndalama zomwe zakhala zikugwiritsidwa ntchito, tingathe kuyembekezera kuti mankhwalawa akukhala otsika mtengo kwambiri. Kotero ife sitiyenera kusunga mpweya wathu.
Pansi
Njira yabwino yowonjezeretsera miyoyo yathu ya HDL ndiyo kukhala ndi moyo wathanzi. Njirayi ili ndi phindu lochepetsa chiopsezo chathu mosasamala za miyoyo yathu ya HDL.
- Werengani momwe mungakulitsire msinkhu wanu wa HDL.
- Werengani za kuyesa chiopsezo cha matenda a mtima.
- Werengani momwe mungachepetsere vuto lalikulu la mtima.
Zotsatira:
Jambulani JC, Ballantyne CM, Barter P, et al. Zotsatira za mchitidwe wochulukitsa lipoprotein mimetic wothandizila CER-001 pa odwala matenda a atherosclerosis odwala omwe ali ndi matenda oopsa a syndromes. European Heart Journal. 29 April 2014 DOI: http://dx.doi.org/10.1093/eurheartj/ehu171
Nissen SE, Tsunoda T, Tuzcu EM, ndi al. Zotsatira za kachilombo ka ApoA-I Milano yokhudzana ndi matenda opatsirana pogonana kwa odwala omwe ali ndi syndromes oopsa kwambiri: kuyesedwa kosasinthika. JAMA 2003; 290: 2292.