Cytotoxic Chemotherapy ndi Other Cytotoxic Agents
Cytotoxic amatanthauza chinthu kapena ndondomeko yomwe imapangitsa selo kusokonezeka kapena selo imfa. Mawu akuti "cyto" amatanthauza selo ndi "poizoni" poizoni.
Cytotoxic Chemotherapy Mankhwala Osokoneza Bongo
Nthawi zambiri mawu akuti "cytotoxic" amatanthauza zotsatira za mankhwala a chemotherapy omwe ali ndi khansa . M'lingaliro limeneli, wothandizira wa cytotoxic angakhale wosiyana ndi wa cytostatic.
Mankhwala osokoneza bongo amatha kulepheretsa kusuntha ndi kukula kwa maselo koma sangapangitse selo imfa mwachindunji.
Mankhwala a cytotoxic amagwira ntchito posokoneza maselo pamalo enaake mu kukula. Mankhwala a cytotoxic angathe kukhudza maselo omwe akukula mofulumira, mwachitsanzo, maselo a kansa, minofu ya tsitsi, fupa la mafupa ndi maselo omwe akugona mmimba ndi m'matumbo. Chifukwa chomwe mankhwala ambiri amagwiritsira ntchito mankhwala osokoneza bongo komanso kuti mankhwala ambiri amatsitsimutsidwa ndi chifukwa chakuti maselo ali m'malo osiyanasiyana mugawidwe.
Cytotoxic Agents
Palinso zinthu zina zotchedwa cytotoxic zomwe zimagwiritsidwa ntchito pa ntchito zosiyanasiyana. Mofanana ndi mankhwala a cytotoxic chemotherapy, izi zimangotanthauza kuti amapha maselo.
Maselo a T cytotoxic
Mankhwala a Cytotoxic sikuti amangotengedwa kuti awononge khansa ndi kulamulira matenda. Matupi athu amapanganso cytotoxic T-cells (cytotoxic T lymphocytes). Maselo a T Cytotoxic ndi mbali ya chitetezo cha mthupi, chomwe chimayang'ana, chimapeza ndi kuwononga maselo omwe amachiza ma virus ndi maselo a khansa.
Chimodzi mwa zinthu zomwe zikuyenda mofulumira kwambiri pa kafukufuku wa khansa tsopano zikuwongolera kupanga ndi kuyambitsa maselo athu a cytotoxic kuti tipewe khansa m'matupi athu.
Chithokomiro cha Cytotoxic
Anthu si okhawo amene amagwiritsa ntchito maselo a cytotoxic T. Mavitamini ena, monga omwe amachokera kwa njoka, mabala ndi zibulu za violin, amakhalanso cytotoxic.
Njira yogwira ntchito
Mankhwala a Cytotoxic angathe kupha maselo m'njira zingapo. Zikhoza kuvulaza selo kuti maselo ake asokonezeke ndipo selo likuphulika (lysis,) kapena akhoza kusokoneza maselo osankhidwa kuti selo liime kukula ndi kugawa.
Kuopsa kwa mankhwala osokoneza bongo
Mankhwala a cytotoxic akhoza kupha maselo a kansa koma amathanso kuwononga maselo abwinobwino, wathanzi.
Cytotoxic vs Genotoxic
Pali chisokonezo pakati pa mawu akuti cytotoxic ndi genotoxic. Mawu akuti cytotoxic amatanthauza mphamvu ya chinthu choyambitsa maselo. Liwu lakuti genotoxic limatanthawuza mphamvu ya chinthu kuti iwononge mwachindunji DNA m'maselo.
Katemera / Mutagenicity
Mafotokozedwe ena ochepa ndi ofunika kufotokozera pamene mukuyankhula za cytotoxicity. Izi zikuphatikizapo:
- Mankhwala a kachenogeni - Kuwonetsa mankhwala a cytotoxic amatha kuwononga DNA zomwe zingathe kutsogolera khansara.
- Mutagenic - Kuwonetsa mankhwala a cytotoxic kungathe kuwononga ma chromosomes m'mimba mwa mwana.
Ichi ndichifukwa chake ndi kofunika kwambiri kuti anthu azikhala osamala akamagwiritsa ntchito mankhwala a cytotoxic ndi zinthu.
Zitetezo za Cytotoxic
Kwa omwe amagwira ntchito ndi mankhwala a cytotoxic kapena zinthu zina, zowonongeka zimalimbikitsidwa makamaka kuti zisawononge khansa komanso kugwirizana.
Zisamaliro zenizeni zidzasiyana mosiyana ndi njira yomwe mungathe kuwonetsera koma zingakhalepo:
- Maguluvesi, okhala ndi makapu amakhala pansi pa magolovesi
- Zovala zam'manja
- Zovala zoyera
- Magalasi otetezera
- Chitetezo cha kupuma
Zotsatira:
California Institute of Technology. Malangizo Ogwiritsa Ntchito Cytotoxic ndi Chemotherapeutic Mankhwala. March 2011. https://www.safety.caltech.edu/documents/33-cytotoxic_drugs_guidelines.pdf