Stelara Ndi Anti Antioclonal Yomwe Imagwiritsidwa Ntchito Kwa Modzichepetsa kwa Crohn's
Mwachidule
Stelara (ustekinumab) ndi mankhwala othandiza kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda (IL) -12 ndi IL-23. Zowonjezereka ndizomwe zimakhala ndi munthu wodwala monoclonal immunoglobulin antibody omwe amalepheretsa IL-12 ndi IL-23 kugwirizanitsa Pununiti. Stelara adalandiridwa mchaka cha 2008 kuti apange mankhwala a psoriasis ndipo tsopano akuvomerezedwa kuti athetse matenda a Crohn.
Mfundo Zofunikira Kwambiri
- Stelara si mankhwala a Crohn's disease
- Stelara amaperekedwa poyamba mwa kulowetsedwa ndipo kenako ndi jekeseni yomwe ikhoza kuchitidwa pakhomo
- Anthu omwe ali ndi matendawa sakuyenera kulandira Stelara
- Pali chiopsezo chowonjezereka cha matenda ndipo zizindikiro zonse za matenda ziyenera kukambidwa ndi dokotala nthawi yomweyo
- Stelara sanaphunzire kwambiri pa nthawi ya mimba ndi kuyamwitsa ndipo dokotala ayenera kufunsidwa pomwepo ngati ali ndi mimba
- Odwala ayenera kuyesedwa chifuwa chachikulu (TB) asanayambe Stelara
Ulamuliro
Stelara amaperekedwa mu njira ziwiri. Chithandizo choyamba ndi Stelara chachitika ndi kulowetsedwa. Mankhwalawa amaperekedwa mwachangu mu malo olowera kulowetsedwa kapena ku ofesi ya dokotala. Mlingo wa Stelara wogwiritsidwa ntchito umadziwika payekha ndipo amawerengedwa kuchokera kulemera kwa wodwalayo. Pambuyo pake, Stelara amaperekedwa ndi jekeseni (subjectaneous injection) (jekeseni yoperekedwa pansi pa khungu) masabata asanu ndi atatu, omwe angathe kuchitidwa kunyumba.
Odwala amaphunzitsidwa ndi namwino kapena katswiri wina wa zamankhwala pa momwe angaperekere jekeseni. Mankhwalawa amabwera mu jekeseni wapadera umene wodwalayo amadzipatsa yekha kapena ali ndi bwenzi lake kapena wachibale wawo. Odwala amatha kuyambitsa Stelara mu ntchafu, m'mimba, m'mabowo, kapena pamtunda.
Zisonyezo
Stelara angapangidwe kuti apange matenda a Crohn a anthu omwe ali ndi zaka zoposa 18. Janssen Biotech, Inc, amene amapanga Stelara, akuti mankhwalawa amavomerezedwa kwa odwala omwe ali ndi matenda a Crohn omwe "sankalola kuti mankhwalawa asamayesetsedwe ndi odwala matenda a immunomodulators kapena corticosteroids koma sanalepheretse kuchipatala ndi chotupa cha necrosis factor (TNF) , kapena amene analephera kapena osasamala mankhwala ndi mmodzi kapena angapo a TNF. " Izi zikutanthauza kuti ndizogwiritsidwa ntchito kwa odwala amene anachiritsidwa ndi mtundu wina wa mankhwala ndipo sanasinthe. Izi zingaphatikizepo mankhwala osokoneza bongo (omwe amateteza chitetezo cha mthupi), steroids monga prednisone , kapena blocker ya TNF (nthawi zina amatchedwa biologics).
Matenda ena otetezedwa ndi matenda omwe Stelara amavomereza ku United States amaphatikizapo psoriasis ndi psoriatic nyamakazi. Stelara sakuvomerezedwa ndi FDA kuti adziwe matenda a zilonda zam'mimba. Stelara sivomerezedwa kuti zigwiritsidwe ntchito kwa ana kapena achinyamata omwe ali ndi zaka 18.
Momwe Ikugwirira Ntchito
Stelara wakhala akugwiritsidwa ntchito pochiza matenda omwe ali ndi chitetezo cha mthupi, ndi matenda a Crohn kukhala matenda atsopano omwe apezeka atagwira ntchito. Stelara imateteza interleuken (IL) -12 ndi IL-23, zomwe zimapezeka m'thupi mwachibadwa koma zimaganizidwa kuti zimapangitsa kutupa kwa Crohn's disease.
Stelara si mankhwala a Crohn's disease.
Yemwe sayenera Kuzitenga
Uzani dokotala wanu ngati muli kapena muli ndi izi:
- Zomwe zinachitidwa kale ndi Stelara
- Malonda a latex, chifukwa sirinji yodzazidwa kale ikhoza kukhala ndi latex
- Chitani katemera watsopano ndi katemera wamoyo, kapena munthu wina m'banja lanu anali ndi katemera wamoyo
- Amalandira chithandizo cha katemera wa bacille Calmette-Guerin (BCG) chifukwa sichiyenera kuperekedwa mkati mwa chaka chotenga Stelara (kaya kale kapena pambuyo)
- Khungu lirilonse limaphulika
- Pakalipano akupeza zifuwa za chifuwa chachikulu, makamaka chifukwa cha zovuta zowopsa
- Kodi munayamba mwalandira chithandizo cha phototherapy
- Amayi kapena akuyamwitsa, kapena angakhale ndi pakati kapena akukonzekera kuyamwa pamene akutenga Stelara
- Khalani ndi mbiri ya matenda kapena matenda omwe alipo
Kuchenjeza Zotsatira za Kukaniza
Chifukwa chimene dokotala adzafunikire kudziwa za zovuta zowononga ndi zilonda zoopsa ndi chifukwa Stelara angasinthe momwe thupi limayankhira kwa ma shoti. Stelara angapangitse kuti zovuta zisawonongeke kapena zowonjezera chiopsezo chokhala ndi vuto linalake atalandira mphuno. Ndikofunika kugwira ntchito mwakhama ndi munthu wotsutsa komanso gastroenterologist kuti achepetse chiopsezo chokumana ndi vuto. Zomwe zimayambitsa matenda aakulu kwa Stelara ndizosawerengeka.
Matenda Ogwirizana
Stelara ingapangitse chiopsezo chotenga matenda chifukwa zingakhudze chitetezo cha mthupi . Odwala ayenera kukhala osamala za kuyang'anira zizindikiro za matenda ndi kuwawuza kwa dokotala nthawi yomweyo. Izi zikuphatikizapo:
- Kupweteka m'mimba
- Kukuda
- Kudula magazi
- Kutsekula m'mimba
- Kutopa
- Misozi
- Kupweteka kwa minofu
- Ululu kapena kuyaka pamene ukukodza
- Kupuma pang'ono
- Kuphulika khungu
- Nsalu
- Kutaya kosawerengeka kosadziwika
Chitetezo
Pakati pa Mimba
Mimba pamene amayi anali kulandira Stelara sanaphunzire kwambiri. Pakhala pali mimba zochepa mwa amayi omwe ali ndi psoriasis amene adatenga Stelara. Izi zonse zakhala zipoti zochitika, zomwe zikutanthauza kuti ndi chinthu chimodzi chomwe chikuphunziridwa. Palibe pulogalamu yaikulu yomwe imawoneka momwe Stelara amakhudzira ana osanabadwe. Zotsatira zake zimakhala ndi kupititsa padera, komabe sipanakhale kufufuza kokwanira kudziwa ngati Stelara sangavulaze mwana.
Mgwirizano wa FDA wa Stelara ndi mtundu B. Izi zikutanthauza kuti zotsatira za Stelara pa mwana wosabadwa sizinaphunzire mozama. Panopa akulimbikitsidwa kuti Stelara azigwiritsidwa ntchito panthawi yomwe ali ndi mimba ngati akufunikira. Dokotala yemwe amalamula Stelara ayenera kulankhulana mwamsanga ngati mimba ikupezeka.
Chifukwa pali zambiri zochepa zokhudzana ndi mimba ndi Stelara, aliyense amene ali ndi pakati amafunsidwa kutenga nawo mbali pa zolembera za mimba poitana 1-877-311-8972. Izi zingathandize asayansi kudziwa zambiri za momwe Stelara amakhudzira amayi ndi makanda kuti asamalire odwala ena m'tsogolomu.
Pa nthawi yobereka
Zimaganiziridwa kuti Stelara amatha kupitilira m'chifuwa ndipo amachotsedwa ndi mwana. Kuchiritsa mwana pamene akulandira Stelara ayenera kukambilana ndi mamembala a gulu lachipatala ndipo ayenera kupanga payekha.
Mawu Ochokera
Stelara wakhala akugwiritsidwa ntchito kuyambira 2008 kuti athetse vutoli. Matenda atsopano omwe Stelara avomerezedwa ndi matenda a Crohn. Ngakhale Stelara si mankhwala, awonetsedwa kuti ndi othandiza pochiza matenda a Crohn kwa odwala ena.
> Zotsatira:
> Engel T, Kopylov U. "Ustekinumab mu matenda a Crohn: umboni wokhalapo ndi malo opaleshoni." Adv Adv Chronic Dis . 2016 Jul; 7: 208-214.
> Janssen Biotech, Inc. 24 Septemba 2016.
> Lamulo RA, la Jesús GR, la Jesús NR, Klumb EM. "Kufufuza mwatsatanetsatane zamakono zomwe zikuperekedwa pofuna kuchiza matenda opatsirana a rheumatic pa nthawi ya mimba ndi lactation." Odzidzimutsa Rev. 2016 Oct; 15: 955-963.
> Niederreiter L, Adolph TE, Kaser A. "Anti-IL-12/23 mu matenda a Crohn: benchi ndi pambali." Zolinga Zamakhwala . 2013 Nov; 14: 1379-1384.
> Rocha K, Piccinin MC, Kalache LF, Reichert-Faria A, Silva de Castro CC. "Mimba pa Ustekinumab Chithandizo cha Psoriasis Wamphamvu." Zachilengedwe . 2015; 231: 103-104.