Pali chidwi chogwiritsidwa ntchito pogwiritsa ntchito nanotechnology ndi zowonongeka mu mankhwala. Zizindikiro zosadziwika zomwe zimapanga zizindikiro zofunika, komanso zipangizo zopanda mphamvu zomwe zimapangitsa njira zowonjezera bwino, zikupita patsogolo. Mbali ina yofunika kwambiri yopititsa patsogolo chipangizo cha nanotechnology ndi chitukuko cha nanoparticles chomwe chingatenge mankhwala ndi kulunjika maselo kapena matenda.
Izi zowonongeka kwambiri za nron "drones" zili ndi mphamvu zambiri mmadera osiyanasiyana a mankhwala. Iwo ayamba kale kulumikizana ndi mapulaneti komanso amagwiritsidwa ntchito kufooketsa chitetezo cha maselo m'matumbo. Mu 2015, matenda amtima adagwiritsanso ntchito mankhwala osokoneza bongo kuti apereke mankhwala ndi kukonzanso mitsempha , kutsegula njira yochizira matenda a umoyo mu njira yatsopano, mwinamwake kupewa matenda a mtima ndi zilonda.
Kugwiritsa Ntchito Nanotechnology Kuthetsa Kutupa
Kafukufuku wa zinyama, omwe amafalitsidwa mu Science Translational Medicine , adanena kuti drones ya nanoyi ingakhale yothandizira kukonzanso chipika cha atherosclerotic, kupanga chipikacho kukhala chosasunthika komanso chochepa kwambiri kuti chiziphwasuka n'kukhala mwazi wopha. Ofufuza kuchokera ku Harvard Medical School, Brigham ndi Women's Hospital ndi Columbia University amapanga zinthu zamanomedicine zomwe zinapangidwira kunyamula zinthu zotsutsa zokhazokha pamalo enieni.
Kupanda kutupa kutupa ndi chinthu chachikulu chomwe chimayambitsa matenda a atherosclerotic.
Pogwiritsira ntchito nano drones yomwe inali ndi mankhwala opangidwa kuchokera ku thupi lokhazikitsa anti-inflammatory protein annexin A1, kusintha kwakukulu kunapezekedwa mu mbewa zomwe zakhala zikuyambitsa matenda a atherosclerosis. Kutentha sikungokhala kokha, mitsempha ya mbewa inakonzedwanso, gawo limodzi la mankhwala omwe ali osiyana ndi mtundu watsopano wa mankhwalawa.
Kukonza mitsempha yowonongeka yowonongeka ikhoza kukhala kofunikira kwambiri kuti zitha kupewa matenda a mtima komanso zingathe kuchepetsa chiwerengero cha anthu omwe amwalira chifukwa cha matenda a atherosclerosis, omwe tsopano akuwongolera matenda ndi imfa ku United States. Zatsimikiziridwa kuti njira yatsopanoyi iyenera kuyendetsedwa bwino ndi kuyesedwa pa anthu, kupereka njira yosangalatsa yotulutsira kutupa ndi kubereka komweko, komwe kumaperekedwa kwa anthu a peptides.
Ofufuza kuchokera ku Weldon School of Biomedical Engineering, Yunivesite ya Purdue, adalongosola njira ina yopambitsira chithandizo cha kutupa pogwiritsira ntchito nanotechnology. Anapanga dongosolo lopangidwa ndi collagen lomwe limagwiritsidwa ntchito pochiza matenda a mitsempha. Njira yatsopanoyi imagwiritsa ntchito nanoparticles yomwe imafika ku collagen ndikumasula peptides odana ndi yotupa. Izi nanoparticles zingachepetsenso kutupa, komanso kulimbikitsa kukonzanso kwa minofu yovulala.
Zilonda zapakatili Zimapangidwanso ndi Nanoparticles
Kukonza kovulaza ndi malo ena ochiritsira kumene nanoparticles ingagwiritsidwe ntchito bwino kuti pakhale njira yovuta yochiritsira nthawi zambiri. Giovanna Leoni ndi anzake ogwira ntchito ku yunivesite ya Emory anagwiritsira ntchito njira zowonjezera za nanoparticles zomwe zili ndi mapuloteni achilengedwe a A1 kwa ammimba omwe ali ovulala m'mimba.
Kuwonongeka kwa mucosal kosatha ndi mbali ya zinthu zambiri zotupa za matumbo, kuphatikizapo ulcerative colitis ndi matenda a Crohn omwe amakhudza anthu pafupifupi 1.6 miliyoni a ku America. Kufufuza kwaposachedwapa pa mbewa kunasonyeza kuti kulumikizana kwazomwe zimapangitsa kuti zitsulo zisawonongeke zikupangitsanso machiritso ovulala ndipo zimalimbikitsa kukonzanso mabala. M'nkhani yawo, yomwe inalembedwa mu Journal of Clinical Investigation , olembawo akusonyeza kuti kutumiza kwapadera kwa peptides mkati mwa nanoparticles kungakhale njira yothandizira anthu omwe akudwala matenda opatsirana (IBD).
Pakhala palinso chidwi pa chitukuko cha nanoparticles zomwe zingathandize kuthana ndi matenda monga IBD. Chinthu chomwe chinachokera ku ginger wodyetsedwa chinagwiritsidwa ntchito bwino mu phunziro lotsogoleredwa ndi MingZheng Zhang wa Georgia State University, Atlanta. Ndalama za nanoparticles zingathe kuchepetsa mavuto okhudzana ndi kupanga mankhwala.
Nanomesh Kuvala Mabala Achilendo
Kugwiritsa ntchito kwina kwa nanotechnology kwawonetsedwa ndi Martina Abrigo ndi gulu lake la ofufuza ku University of Swinburne University of Technology. Abrigo akufufuza ntchito zakunja zazing'ono zapadera kuti zithetse zilonda zapachilombo. Anapanga mesh kuchokera ku ma electrospun polystyrene fibers omwe amakonzedwa kuti akope mabakiteriya. Ndalama ya nanomesh imapangitsa kuti mabakiteriya monga Staphylococcus Aureus ndi Escherichia Coli apitirize kukula bwino. Kugwiritsa ntchito mabakiteriya pamasomasi osiyanasiyana ofiira diameters kunayesedwa kupyolera mu kuphatikiza microscopy ya electron ndi microscopy ya confocal.
Mabakiteriya ankakopeka kwambiri ndi ulusi womwe unali wofanana kwambiri ndi iwo. Zotsatira, zofalitsidwa mu ACS Applied Materials ndi Interfaces , zimasonyeza kuti electrospinning nanofibers ikhoza kukhala njira yatsopano yothetsera mabala omwe ali ndi kachilombo ka HIV. Pakalipano, asayansi akhala akuyesa zowonongeka chabe ndi kuyesera pazithunzithunzi zopangidwa ndi zitsamba. Komabe, zikuyembekezereka kuti posachedwapa, mayesero ofananawo adzachitidwa pa ziwalo zamoyo kuti aone momwe zingakhalire njira yatsopanoyi. Maphunziro a vivo akhala akuchitidwa kale ndi mitundu ina ya mavalidwe opangidwa ndi bala, mwachitsanzo, ndalama za nanoparticles zomwe zimapambana.
> Zotsatira:
> Abrigo M, Kingshott P, McArthur S. Electrospun polystyrene fiber m'mimba mwake yomwe imayambitsa kugwirizana kwa mabakiteriya, kuchulukira, ndi kukula. ACS Applied Materials ndi Interfaces , 2015; 7 (14): 7644-7652.
> Fredman G, Spolitu S, Perretti M, et al. Ndalama za nanoparticles zomwe zimakhala ndi peptide yopumula Ac2-26 zimateteza kuti zisagwiritsidwe bwino kwa atherosclerosis mu mbewa za hypercholesterolemic. Sayansi yotanthauzira mankhwala , 2015; 7 (275).
> Leoni G, Neumann P, Reutelingsperger C, et al. Annexin A1'madzi odzola owonjezera omwe amapangidwa ndi apolymeric nanoparticles amalimbikitsa kukonzanso kwapadera. Journal of Investigation Clinic , 2015; 125 (3): 1215-1227.
> McMasters J, Patali A. Chidzalo chokwanira: Collagen-yomanga nanoparticles ya peptide yoperewera yotupa yowonjezera kutaya mapulogalamu, imalimbikitsa kutha msinkhu, ndikuletsa kutentha. Acta Biomaterialia , 2017; 49: 78-88.
> Zhang M, Viennois E, Merlin D, et al. Zakudya zodyedwa ndi ginger-derived nanoparticles: Njira yatsopano yothandizira kupewa ndi kuchiza matenda opatsirana ndi matenda a khansa. Zida zamakono , 2016; 101: 321-340.