Choyamba JAK Inhibitor ya Matenda a Matenda a Khunyu Ovomerezedwa ndi FDA
Xeljanz (tofacitinib citrate), DMARD yomlomo (anti-rheumatic drug), inavomerezedwa ndi US Food and Drug Administration (FDA) pa November 6, 2012. Mankhwalawa amapangidwa kuti athe kuchiritsira akuluakulu moyenera- Matenda a nyamakazi odwala matenda a nyamakazi omwe sanagwiritse ntchito mokwanira, kapena kusalolera, kuti apeze methotrexate . Zopangidwa ndi Pfizer, Xeljanz ndi piritsi yozungulira, yoyera, yomwe imatulutsidwa pulojekiti yomwe ili ndi "Pfizer" mbali imodzi, ndipo "JKI5" imalembedwa pambali inayo.
Xeljanz ndi DMARD yoyamba yemlomo yomwe imavomereza kuti nyamakazi ikhale ndi nyamakazi m'zaka 10. Ndilo loyamba m'kalasi latsopano la mankhwala otchedwa JAK (Janus kinase) inhibitors. Xeljanz ingagwiritsidwe ntchito monga monotherapy (yokha), kapena kuphatikiza ndi methotrexate kapena DMARD zina zosakhala zachilengedwe. Xeljanz sayenera kugwiritsidwa ntchito ndi mankhwala osokoneza bongo kapena amphamvu, monga Imuran (azathioprine) kapena cyclosporine .
Momwe Ikugwirira Ntchito
Kwenikweni, Xeljanz amagwira ntchito poletsa njira ya JAK - njira yowonetsera mkati mwa maselo omwe amathandiza kwambiri kutupa kamene kamayambitsa matenda a nyamakazi. JAKs ndi mavitamini opanga maselo omwe amapereka zizindikiro zomwe zimachokera ku cytokine kapena kukula kwa factor-receptor ku selo.
Xeljanz imatengedwa kuti ndi yaing'ono-molecule mankhwala, osati mankhwala a biologic. Hito (adalimumab), Cimzia (certolizumab pegol), Simponi (golimumab), Orencia (abatacept), Actemra (tocilizumab), ndi Rituxan (rituximab) zomwe zimapangitsa kuti ziphuphu zisawonongeke. kuchokera kunja kwa selo.
Kuchita Zokakamiza
Odwala nyamakazi oposa 5,000 odwala matenda a chifuwa amakhulupirira kuti Xeljanz akuyesa matendawa, ndipo amachititsa chimodzimodzi mwazidzidzidzi za mankhwala odwala nyamakazi.
Panali mayesero awiri a chipatala omwe anayeza mlingo woyenera wa Xeljanz, ndi mayesero asanu omwe adayesa mayankho a ACR 20 ku Xeljanz, komanso DAS28 ndi zotsatira za kafukufuku wa zaumoyo.
Zilonda zam'chipatala zasonyeza kuti Xeljanz inachepetsa kwambiri zizindikiro ndi zizindikiro za nyamakazi ya nyamakazi komanso ntchito yabwino ya thupi (kuthekera kuchita zochitika za tsiku ndi tsiku).
Mlingo
Xeljanz imatengedwa pamlomo, 5 mg mapiritsi atengedwa kawiri tsiku lililonse. Zingatengedwe kapena popanda chakudya. Mlingo wa 11 mg kamodzi-tsiku ndi tsiku umapezeka tsopano monga Xeljanz-XR (kutulutsidwa kwowonjezera).
Zotsatira Zogwirizana
Zotsatira zovuta kwambiri zomwe zimagwirizanitsidwa ndi Xeljanz, zomwe zinachitika m'miyezi itatu yoyamba yogwiritsidwa ntchito m'mayesero a zachipatala, anali ndi matenda opatsirana, kupweteka kwa m'mimba, kutsekula m'mimba, ndi nasopharyngitis.
Chenjezo ndi Kusamala
Xeljanz akupereka chenjezo lotsekemera: matenda akuluakulu omwe amachititsa kuchipatala kapena kufa, kuphatikizapo chifuwa chachikulu ndi bakiteriya, bowa losagwidwa, tizilombo toyambitsa matenda, ndi matenda ena opatsirana, achitika ndi odwala omwe alandira Xeljanz; ngati matenda akuluakulu akukula, Xeljanz iyenera kuimitsidwa mpaka matenda atayikidwa; Mayeso oyenera a chifuwa chachikulu ayenera kuperekedwa asanayambe Xeljanz; odwala omwe amatenga Xeljanz ayenera kuyang'anitsitsa chifukwa cha chifuwa chachikulu ngakhale chiyeso choyambirira ndi choipa; Lymphoma ndi zowopsya zina zakhala zikuwonedwa ndi odwala omwe amatenga Xeljanz; "Epstein Barr Virus-associated associated lymphoproliferative disorder" yakhala ikuwonedwa mu kupalesanso kwa anthu odwala ndi Xeljanz kuphatikizapo mankhwala osokoneza bongo.
Zitetezo zina: Gwiritsani ntchito Xeljanz mosamala kwa odwala omwe ali pangozi ya m'mimba mwachisawawa; Xeljanz sivomerezedwa kwa odwala matenda aakulu a chiwindi; Kuyeza kwa ma laboratori nthawi zonse kumalimbikitsidwa chifukwa Xeljanz ikhoza kusintha kusintha kwa mitundu yambiri ya maselo oyera a magazi, hemoglobin, mapuloteni a chiwindi , ndi lipids; odwala omwe amatenga Xeljanz sayenera kulandira katemera wamoyo.
Maphunziro oyenerera a Xeljanz mu amayi apakati sanachitike. Xeljanz iyenera kugwiritsidwa ntchito panthawi yomwe ali ndi mimba ngati phindu la mankhwalawa likuposa chiopsezo cha mwanayo.
Ndalama
Xeljanz adzakhala ndi ndalama zambiri zogula ndalama zokwana madola 2,055.13 kwa masiku 30 (kapena $ 24,666 pachaka).
Mtengo wa odwala umasiyana malinga ndi malonda ndi inshuwalansi.
> Zotsatira:
> Xeljanz. Kufotokozera mwatsatanetsatane Mauthenga ndi Mankhwala Amadzimadzi. Zosinthidwa 02/2016.
> Ulamuliro wa US Food and Drug umavomereza Pfizer wa XELJANZ (tofacitinib citrate) kwa Akuluakulu Omwe Amakhala ndi Matenda Ovuta Kwambiri Odwala Matenda a Khunyu (RA) Amene Alibe Yankho Loyenera Kapena Kusagwirizana ndi Methotrexate. 11/06/2012.
> Xeljanz, Pills Pabizer Yopanda Pakati pa 25,000-A Year Year For Rheumatoid Arthritis, Ikulandira FDA Green Light. Mateyu Herper. Forbes.com. 11/06/2012.